DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment polo and plk4

DIOPT Version :9

Sequence 1:	NP_001014592.1	Gene:	polo / 40232	FlyBaseID:	FBgn0003124	Length:	576	Species:	Drosophila melanogaster
Sequence 2:	XP_005158928.1	Gene:	plk4 / 368390	ZFINID:	ZDB-GENE-030619-14	Length:	963	Species:	Danio rerio

Alignment Length:	448	Identity:	137/448 - (30%)
Similarity:	236/448 - (52%)	Gaps:	46/448 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 DRLVD--INQR-KTYKRMRFFGKGGFAKCYEIIDVETDDVFAGKIVSKKLMIKHNQKEKTAQEIT 75
            ||:::  ::.| :.:|.:...|||.||..|....|.|....|.|::.||.|.|....::...|:.
Zfish    20 DRILEPSVDLRIEDFKVLTLLGKGSFACVYRAKSVNTGLEVAIKMIDKKAMHKAGMVQRVINEVE 84

  Fly    76 IHRSLNHPNIVKFHNYFEDSQNIYIVLELCKKRSMMELHKRRKS-ITEFECRYYIYQIIQGVKYL 139
            |...|.||::::.:||||||..:|:|||:|....|....|.||: .||.|.|::::||::|:.||
Zfish    85 IQCRLKHPSVLELYNYFEDSNYVYLVLEMCHNGEMSRYLKERKNPFTEEEARHFMHQIVKGMLYL 149

  Fly   140 HDNRIIHRDLKLGNLFLNDLLHVKIGDFGLATRIEYEGERKKTLCGTPNYIAPEILTKKGHSFEV 204
            |.:.|:||||.|.||.|...:::||.||||||:::...|:..|:|||||||:||:.|:..|..|.
Zfish   150 HTHGIMHRDLTLTNLLLTTSMNIKIADFGLATQLKLPSEKHFTMCGTPNYISPEVATRSAHGLES 214

  Fly   205 DIWSIGCVMYTLLVGQPPFETKTLKDTYSKIKKCEYRVPSYLRKPAADMVIAMLQPNPESRPAIG 269
            |:||:||:.|..|.|:|||:|.|:|.|.:|:...||::|.::...|.|::..:||.||..||::.
Zfish   215 DVWSLGCMFYAFLTGRPPFDTDTVKRTLNKVVLGEYQMPMHISAEAQDLIQQLLQKNPALRPSLS 279

  Fly   270 QLLNFEFL----------KGSKVPMFLPSSCLTMAPRIGSNDTIEDSMHRKPLMEMNGIRPDDTR 324
            .:|:..|:          .||.....:.|...|::....:.:....|..::...:|.| :|..:|
Zfish   280 AVLDHPFMTQSGPTASKDSGSSDGGSIDSGIATISTASNATNNSSSSRLQRRTRQMIG-QPLPSR 343

  Fly   325 LESTFLKANLHDAITASAQVCRHSEDYRSDIESLYQQLTNLINGKPRILQGNLGDENTDPAAQPL 389
            :..  :.::.|.:.::|   .:..:|::.:.:....::     |..||   .:|.::..|.::.|
Zfish   344 MAP--IPSHSHHSTSSS---FKSGQDWQPNSQDDLSRM-----GVGRI---PVGADSGRPHSRYL 395

  Fly   390 FWISKWVDYSDKYGFGY---------QLCD-----EGIGVMFNDTTKLILLPNQINVH 433
                :....||:...||         :.|.     .|.|.:|..|:.....|:..:.|
Zfish   396 ----RRAHSSDRSAVGYSHNPQEAELERCHSEEMLSGAGRLFPQTSGYRNAPHGYSKH 449

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
polo	NP_001014592.1	STKc_PLK	23..277	CDD:271001	104/254 (41%)
		POLO_box_1	388..475	CDD:240561	12/60 (20%)
		POLO_box_2	490..570	CDD:240560
plk4	XP_005158928.1	STKc_PLK4	32..287	CDD:271088	104/254 (41%)
		S_TKc	34..287	CDD:214567	104/252 (41%)
		POLO_box_Plk4_1	588..698	CDD:240557
		POLO_box_Plk4_2	699..808	CDD:240558
		POLO_box_Plk4_3	878..957	CDD:240559
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0575
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D507604at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820