Protein Alignment polo and Plk5

DIOPT Version :10

• Sequence 1: NP_524179.2
• Gene: polo / 40232
• FlyBaseID: FBgn0003124
• Length: 576
• Species: Drosophila melanogaster
• Sequence 2: NP_001424353.1
• Gene: Plk5 / 314627
• RGDID: 1305038
• Length: 614
• Species: Rattus norvegicus
• Alignment Length: 618
• Identity: 189/618 - (30%)
• Similarity: 288/618 - (46%)
• Gaps: 84/618 - (13%)

  Fly    16 LVDINQRKTYKRMRFFGKGGFAKCYEIIDVETDDVFAGKIVSKKLMIKHNQKEKTAQEITIHRSL 80
            |.|....:.|:|.:..|||.|::||::.|:.|..|||.|:|.:....:...:.|..:||.:|..|
  Rat    18 LRDPGSGRVYRRGKLIGKGAFSRCYKLTDMSTSAVFALKVVPRGGAGRLRLRGKVEREIALHSRL 82

  Fly    81 NHPNIVKFHNYFEDSQNIYIVLELCKKRSMMELHKRRKSITEFECRYYIYQIIQGVKYLHDNRII 145
            :|.|||.||.:|.|..::|:|||.|.::|:..:.|.|:::||.|.|||...::.|::|||..||:
  Rat    83 HHRNIVAFHAHFADRDHVYMVLEYCSRQSLAHVLKVRRTLTEPEVRYYFRGLVSGLRYLHQQRIV 147

  Fly   146 HRDLKLGNLFLNDLLHVKIGDFGLATRIEYEGERKKTLCGTPNYIAPEILTKKGHSFEVDIWSIG 210
            |||||..|.|||..:.|||||.|||.|:...|...:.||||||:.|||::::.|||.:.|||::|
  Rat   148 HRDLKPSNFFLNKNMEVKIGDLGLAARVGPAGRCHRVLCGTPNFQAPEVVSRNGHSAKSDIWALG 212

  Fly   211 CVMYTLLVGQPPFETKTLKDTYSKIKKCEYRVPSYLRKPAADMVIAMLQPNPESRPAIGQLLNFE 275
            |:|||:|.|.|||....|.:.|..|:...|..|:.|...|..::..:|.|:|:.||::..||..:
  Rat   213 CIMYTVLTGTPPFAAAPLSEMYQNIRDGHYLEPTQLSPSARSLIARLLAPDPDERPSLDHLLQDD 277

  Fly   276 FLKGSKVPMFL-PSSC-----LTMAPRIGSNDTIEDSMHRK-------------PLMEMNGIRPD 321
            |......|..| |.||     ....|.:|       .:.||             |........|.
  Rat   278 FFSQGFTPERLPPHSCHSPPVFAFPPPLG-------RLFRKVGQLLLTQCRPPCPFTSKEASGPG 335

  Fly   322 DTRLESTFLKANLHDAITASAQVCRHSEDYRSDIESLYQQLTNLINGKPRI-LQ----------- 374
            :...|...::|:..:    .|.:|..|   |..:.:|....|:..:.|..: ||
  Rat   336 EESTEPDHMEASNEE----GAPLCTES---RIHLLTLGTPRTDPADAKGTLALQLEVATRKLCLC 393

  Fly   375 ---GNLGDENT------------DPAAQ-------PLFWISKWVDYSDKYGFGYQLCDEGIGVMF 417
               |.:|...|            .||.|       .:.|..||||||.||||||||.|.|.||:|
  Rat   394 LDAGPVGRTATPKCRTEAAWRGPKPAGQDPPGEQRSVLWAPKWVDYSLKYGFGYQLSDGGSGVLF 458

  Fly   418 NDTTKLILLPNQINVHFIDKDGKETYMTTTDYCKSLDKKMKLLSYFKRYMIEHLVKAGANNVNIE 482
            .|.:.:.|.|...:|.:....|........|....|..|:.:|..|..||...|.:.|
  Rat   459 RDGSHMALRPPGGHVSYQPDQGTLWIFALRDVPGPLRAKLAVLRLFACYMQRRLREEG------- 516

  Fly   483 SDQISRMPH-----LHSWFRTTCAVVMHLTNGSVQLNF-SDHMKLILCPRMSAITYMDQEKN--- 538
            :..::..|.     |.|:.....|:.|..:||:||::. :..::|:|...........||..
  Rat   517 TAPMTATPASPDFCLLSFTADAQALAMLFSNGTVQVSSKTSPVQLVLSGEGEDFLLTIQEPGGPS 581

  Fly   539 -FRTYRFSTIVENGVSKDLYQKIRYAQEKLRKM 570
             ..:|....:..:|:|..:...:|.....|:.:
  Rat   582 MGTSYTLDVLRSHGISLAVRHHLRLGLHLLQSV 614

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
polo	NP_524179.2	STKc_PLK	23..277	CDD:271001	106/253 (42%)
		POLO_box_1	388..475	CDD:240561	33/86 (38%)
		POLO_box_2	490..570	CDD:240560	18/89 (20%)
Plk5	NP_001424353.1	None