Protein Alignment polo and plk1

DIOPT Version :10

• Sequence 1: NP_524179.2
• Gene: polo / 40232
• FlyBaseID: FBgn0003124
• Length: 576
• Species: Drosophila melanogaster
• Sequence 2: NP_001003890.3
• Gene: plk1 / 280649
• ZFINID: ZDB-GENE-021115-7
• Length: 595
• Species: Danio rerio
• Alignment Length: 595
• Identity: 297/595 - (49%)
• Similarity: 412/595 - (69%)
• Gaps: 44/595 - (7%)

  Fly     2 AAKP----EDKST---DIPDRLVDINQRKTYKRMRFFGKGGFAKCYEIIDVETDDVFAGKIVSKK 59
            :|||    :.||.   :|||.|||....|.|.|.||.|||||||||||.|::|.:|||||:|.|.
Zfish     9 SAKPSAHVDPKSAPLKEIPDVLVDPRTMKRYMRGRFLGKGGFAKCYEITDMDTKEVFAGKVVPKS 73

  Fly    60 LMIKHNQKEKTAQEITIHRSLNHPNIVKFHNYFEDSQNIYIVLELCKKRSMMELHKRRKSITEFE 124
            :::|.:||||.:.||.||:||::|::|.||.:|||...:|:|||:|::||::|||||||::||.|
Zfish    74 MLLKPHQKEKMSTEIAIHKSLDNPHVVGFHGFFEDDDFVYVVLEICRRRSLLELHKRRKAVTEPE 138

  Fly   125 CRYYIYQIIQGVKYLHDNRIIHRDLKLGNLFLNDLLHVKIGDFGLATRIEYEGERKKTLCGTPNY 189
            .||::.|.||||:|||:||:||||||||||||||.:.||||||||||:||::|||||||||||||
Zfish   139 ARYFMRQTIQGVQYLHNNRVIHRDLKLGNLFLNDDMDVKIGDFGLATKIEFDGERKKTLCGTPNY 203

  Fly   190 IAPEILTKKGHSFEVDIWSIGCVMYTLLVGQPPFETKTLKDTYSKIKKCEYRVPSYLRKPAADMV 254
            ||||:|.||||||||||||:||::||||||:|||||..||:||.:|||.||.||.::...|:.::
Zfish   204 IAPEVLCKKGHSFEVDIWSLGCILYTLLVGKPPFETSCLKETYIRIKKNEYSVPRHINPVASALI 268

  Fly   255 IAMLQPNPESRPAIGQLLNFEFLKGSKVPMFLPSSCLTMAPRIG-SNDTIEDSMHRKPLMEMNGI 318
            ..||..:|..||::.:||..||......||.||:||||:.||.. :..:::.::.||||..:|
Zfish   269 RRMLHADPTLRPSVAELLTDEFFTSGYAPMRLPTSCLTVPPRFSIAPSSLDPALLRKPLSSLN-- 331

  Fly   319 RPDDTRLESTFLKANLHDAITASAQVCRHSEDYRSDIE-------------SLYQQLTNLINGKP 370
            :..|:.:|                ::.:..:..|.|::             .:.|||..:...||
Zfish   332 KGTDSPIE----------------EMGKMDQPQREDLQQRDGPEQPDTHLTDMLQQLAVVNAAKP 380

  Fly   371 RILQGNLGDENTDPAAQPLFWISKWVDYSDKYGFGYQLCDEGIGVMFNDTTKLILLPNQINVHFI 435
            ........:|..|||..|:||||||||||||||.||||.|..:||:|||:|:||:..:..::.:|
Zfish   381 SDRDFIRQEEAEDPACIPVFWISKWVDYSDKYGLGYQLSDNSVGVLFNDSTRLIMCADGDSLQYI 445

  Fly   436 DKDGKETYMTTTDYCKSLDKKMKLLSYFKRYMIEHLVKAGANNVNIESDQISRMPHLHSWFRTTC 500
            |::..|:|::...|..:|.||:.||.||:.||.|||:|||||....|.|:::|:|:|..||||..
Zfish   446 DRNSLESYLSVRSYPSALSKKITLLKYFRNYMSEHLLKAGANITPREGDELTRLPYLRHWFRTKS 510

  Fly   501 AVVMHLTNGSVQLN-FSDHMKLILCPRMSAITYMDQEKNFRTYRFSTIVENGVSKDLYQKIRYAQ 564
            |:|:||:||:||:| |.||.||||||.|.|:||:::::.|.||:.:.|.|.|..|:|..::|||
Zfish   511 AIVLHLSNGTVQINFFQDHTKLILCPLMGAVTYINEKREFYTYKMTLIEEFGCCKELASRLRYA- 574

  Fly   565 EKLRKMLEKM 574
               |.|:||:
Zfish   575 ---RNMVEKL 581

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
polo	NP_524179.2	STKc_PLK	23..277	CDD:271001	161/253 (64%)
		POLO_box_1	388..475	CDD:240561	46/86 (53%)
		POLO_box_2	490..570	CDD:240560	40/80 (50%)
plk1	NP_001003890.3	STKc_PLK1	31..295	CDD:271089	164/263 (62%)
		POLO_box_1	398..485	CDD:240561	46/86 (53%)
		POLO_box_2	500..581	CDD:240560	42/84 (50%)