DRSC/TRiP Functional Genomics Resources

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Protein Alignment polo and Plk1

DIOPT Version :10

Sequence 1:NP_524179.2 Gene:polo / 40232 FlyBaseID:FBgn0003124 Length:576 Species:Drosophila melanogaster
Sequence 2:NP_058796.2 Gene:Plk1 / 25515 RGDID:3352 Length:603 Species:Rattus norvegicus


Alignment Length:570 Identity:305/570 - (53%)
Similarity:415/570 - (72%) Gaps:26/570 - (4%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 DIPDRLVDINQRKTYKRMRFFGKGGFAKCYEIIDVETDDVFAGKIVSKKLMIKHNQKEKTAQEIT 75
            :||:.|:|...|:.|.|.||.||||||||:||.|.:|.:|||||||.|.|::|.:||||.:.||:
  Rat    39 EIPEVLMDPRSRRQYVRGRFLGKGGFAKCFEISDSDTKEVFAGKIVPKSLLLKPHQKEKMSMEIS 103

  Fly    76 IHRSLNHPNIVKFHNYFEDSQNIYIVLELCKKRSMMELHKRRKSITEFECRYYIYQIIQGVKYLH 140
            |||||.|.::|.||.:||||..:::|||||::||::|||||||::||.|.|||:.||:.|.:|||
  Rat   104 IHRSLAHQHVVGFHGFFEDSDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLH 168

  Fly   141 DNRIIHRDLKLGNLFLNDLLHVKIGDFGLATRIEYEGERKKTLCGTPNYIAPEILTKKGHSFEVD 205
            .|::|||||||||||||:.|.||||||||||::||||||||||||||||||||:|:|||||||||
  Rat   169 RNQVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYEGERKKTLCGTPNYIAPEVLSKKGHSFEVD 233

  Fly   206 IWSIGCVMYTLLVGQPPFETKTLKDTYSKIKKCEYRVPSYLRKPAADMVIAMLQPNPESRPAIGQ 270
            :|||||:|||||||:|||||..||:||.:|||.||.:|.::...||.::..|||.:|.:||.|.:
  Rat   234 VWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTIHE 298

  Fly   271 LLNFEFLKGSKVPMFLPSSCLTMAPRIGSNDTIEDSMHRKPLMEMN-GIR---PDDTRLESTFLK 331
            |||.||.....:|..||.:|||:.||.....:..|..:||||..:| |:.   ||..|.:...:.
  Rat   299 LLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGVENPLPDRPREKEEPVV 363

  Fly   332 ANLHDAITASAQVCRHSEDYRSDIESLYQQLTNLINGKPR----ILQGNLGDENTDPAAQPLFWI 392
            ...::||          |.:.||   |.||||::...||.    :.|    :|..|||..|:||:
  Rat   364 RETNEAI----------ECHLSD---LLQQLTSVNASKPSERGLVRQ----EEAEDPACIPIFWV 411

  Fly   393 SKWVDYSDKYGFGYQLCDEGIGVMFNDTTKLILLPNQINVHFIDKDGKETYMTTTDYCKSLDKKM 457
            |||||||||||.||||||..:||:|||:|:|||..:..::.:|::||.|:|:|.:.:..||.||:
  Rat   412 SKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKI 476

  Fly   458 KLLSYFKRYMIEHLVKAGANNVNIESDQISRMPHLHSWFRTTCAVVMHLTNGSVQLN-FSDHMKL 521
            .||:||:.||.|||:|||||....|.|:::|:|:|.:||||..|:::||:||:||:| |.||.||
  Rat   477 TLLNYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGTVQINFFQDHTKL 541

  Fly   522 ILCPRMSAITYMDQEKNFRTYRFSTIVENGVSKDLYQKIRYAQEKLRKML 571
            ||||.|:|:||::::::|||||.|.:.|.|..|:|..::|||:..:.|:|
  Rat   542 ILCPLMAAVTYINEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLL 591

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
poloNP_524179.2 STKc_PLK 23..277 CDD:271001 166/253 (66%)
POLO_box_1 388..475 CDD:240561 49/86 (57%)
POLO_box_2 490..570 CDD:240560 40/80 (50%)
Plk1NP_058796.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..32
STKc_PLK1 45..309 CDD:271089 169/263 (64%)
Activation loop. /evidence=ECO:0000250 194..221 24/26 (92%)
D-box that targets the protein for proteasomal degradation in anaphase. /evidence=ECO:0000250 337..340 2/2 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 338..361 8/22 (36%)
POLO_box_1 407..494 CDD:240561 49/86 (57%)
Linker. /evidence=ECO:0000250 493..507 6/13 (46%)
POLO_box_2 509..590 CDD:240560 40/80 (50%)
Important for interaction with phosphorylated proteins. /evidence=ECO:0000250 538..540 1/1 (100%)
Blue background indicates that the domain is not in the aligned region.

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