Protein Alignment polo and plo1

DIOPT Version :9

• Sequence 1: NP_001014592.1
• Gene: polo / 40232
• FlyBaseID: FBgn0003124
• Length: 576
• Species: Drosophila melanogaster
• Sequence 2: NP_593647.1
• Gene: plo1 / 2541957
• PomBaseID: SPAC23C11.16
• Length: 683
• Species: Schizosaccharomyces pombe
• Alignment Length: 667
• Identity: 218/667 - (32%)
• Similarity: 334/667 - (50%)
• Gaps: 132/667 - (19%)

  Fly    20 NQRKT--YKRMRFFGKGGFAKCYEIIDVETDDVFAGKIVSKKLMIKHNQKEKTAQEITIHRSLNH 82
            |.:|.  |.|....|:||||:|:.:.| ...:::|.|:::|:.:.....|.|...||.:|:|::|
pombe    34 NNKKNIFYTRYDCIGEGGFARCFRVKD-NYGNIYAAKVIAKRSLQNDKTKLKLFGEIKVHQSMSH 97

  Fly    83 PNIVKFHNYFEDSQNIYIVLELCKKRSMMELHKRRKSITEFECRYYIYQIIQGVKYLHDNRIIHR 147
            ||||.|.:.||||.|||::||||:.:|:|||.::||.:||.|.||.:.||:..:||:|..|:|||
pombe    98 PNIVGFIDCFEDSTNIYLILELCEHKSLMELLRKRKQLTEPEVRYLMMQILGALKYMHKKRVIHR 162

  Fly   148 DLKLGNLFLNDLLHVKIGDFGLATRIEYEGERKKTLCGTPNYIAPEIL--TKKGHSFEVDIWSIG 210
            ||||||:.|::..:|||||||||..:..:.|||.|:||||||||||||  :|:|||||||:||.|
pombe   163 DLKLGNIMLDESNNVKIGDFGLAALLMDDEERKMTICGTPNYIAPEILFNSKEGHSFEVDLWSAG 227

  Fly   211 CVMYTLLVGQPPFETKTLKDTYSKIKKCEYRVPSY--LRKPAADMVIAMLQPNPESRPAIGQLLN 273
            .|||.||:|:|||:.|.:|..|.|||...|..||.  :...|.|::.::|..:|..||:|..:::
pombe   228 VVMYALLIGKPPFQDKEVKTIYRKIKANSYSFPSNVDISAEAKDLISSLLTHDPSIRPSIDDIVD 292

  Fly   274 FEFLKGSKVPMFLPSSCLTMAP----------------------RIG------------------ 298
            .||.....:...||...|...|                      .:|
pombe   293 HEFFHTGYMASTLPDEILHSMPIWPSSQSKSSFQRNLDFVASASGVGFGNSAGVEKNKPYALRTD 357

  Fly   299 --SNDTIEDSM-----HRKPLMEMNGIRPDDTRLESTFLKANLHDAITASAQVCRHSED--YRSD 354
              .||.|..|:     ...|:|::.    .:|:...:.|...||.|        |.|.|  ..|.
pombe   358 EVDNDRILPSVLSPRDRVNPVMKIG----PETKPVPSKLSTALHAA--------RKSTDGSLGSR 410

  Fly   355 IESLYQQLTNLINGKPRILQ----------------------GNLGDE----------------- 380
            ::.|.::..:.:..|..:.:                      ||:..:
pombe   411 VKVLREESQSFVPTKSAVTEQVEPIQLIRSLSANTVSRLSKVGNMKSDIWISVKKTALKIGMALE 475

  Fly   381 -------NTDPAAQPLFWISKWVDYSDKYGFGYQLCDEGIGVMFNDTTKLILLPNQINVHFI--- 435
                   :.|..::|:.:|:||||||:|||.||||.||.:||.|||.|.|:...::..|.:.
pombe   476 AHTHALTSEDADSEPVLFITKWVDYSNKYGLGYQLSDESVGVHFNDDTSLLFSADEEVVEYALHP 540

  Fly   436 -DKDGKETYMTTTDYCKSLDKKMKLLSYFKRYMIEHLVKAGANN-----VNIESDQISRMPHLHS 494
             |.:.|......:...:|:..|::||.:||.||.::|.||..:.     .|..|:.:..|.|
pombe   541 KDTEIKPYIYPASKVPESIRSKLQLLKHFKSYMGQNLSKAVQDESFEKPKNSTSNTMLFMQH--- 602

  Fly   495 WFRTTCAVVMHLTNGSVQLNFSDHMKLILCPRMSAITYMDQEKNFRTYRFSTIVE--NGVSKDLY 557
            :.||..|::..|:||..|.||.||.|:::......|..:|:|:.    |....::  :..|:||.
pombe   603 YLRTRQAIMFRLSNGIFQFNFLDHRKVVISSTARKIIVLDKERE----RVELPLQEASAFSEDLR 663

  Fly   558 QKIRYAQEKLRKMLEKM 574
            .:::|.:|.|.....||
pombe   664 SRLKYIRETLESWASKM 680

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
polo	NP_001014592.1	STKc_PLK	23..277	CDD:271001	125/259 (48%)
		POLO_box_1	388..475	CDD:240561	37/90 (41%)
		POLO_box_2	490..570	CDD:240560	23/81 (28%)
plo1	NP_593647.1	STKc_PLK	41..296	CDD:271001	124/255 (49%)
		S_TKc	41..296	CDD:214567	124/255 (49%)
		POLO_box_1	490..580	CDD:240561	36/89 (40%)
		POLO_box_2	599..676	CDD:240560	24/83 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	254	1.000	Domainoid score	I390
eggNOG	1	0.900	-	-		E1_KOG0575
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	364	1.000	Inparanoid score	I449
OMA	1	1.010	-	-		QHG54080
OrthoFinder	1	1.000	-	-		FOG0000754
OrthoInspector	1	1.000	-	-		oto101092
orthoMCL	1	0.900	-	-		OOG6_100759
Panther	1	1.100	-	-	LDO	PTHR24345
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R930
SonicParanoid	1	1.000	-	-		X638
TreeFam	1	0.960	-	-
	13	12.860