Protein Alignment polo and Plk5

DIOPT Version :10

• Sequence 1: NP_524179.2
• Gene: polo / 40232
• FlyBaseID: FBgn0003124
• Length: 576
• Species: Drosophila melanogaster
• Sequence 2: NP_001420485.1
• Gene: Plk5 / 216166
• MGIID: 3026984
• Length: 608
• Species: Mus musculus
• Alignment Length: 607
• Identity: 186/607 - (30%)
• Similarity: 287/607 - (47%)
• Gaps: 68/607 - (11%)

  Fly    16 LVDINQRKTYKRMRFFGKGGFAKCYEIIDVETDDVFAGKIVSKKLMIKHNQKEKTAQEITIHRSL 80
            |.|....:.|:|.:..|||.|::||::.|:.|..|||.|:|.:....:...:.|..:||.:|..|
Mouse    18 LRDPGSGRVYRRGKLIGKGAFSRCYKLTDMSTSAVFALKVVPRGGAGRLRLRGKVEREIALHSRL 82

  Fly    81 NHPNIVKFHNYFEDSQNIYIVLELCKK-------------RSMMELHKRRKSITEFECRYYIYQI 132
            .|.|||.||.:|.|..::|:|||.|.:             :|:..:.|.|:::||.|.|||:..:
Mouse    83 RHRNIVAFHAHFADRDHVYMVLEYCSRQIHNPSNKYQVPLQSLAHVLKVRRTLTEPEVRYYLRGL 147

  Fly   133 IQGVKYLHDNRIIHRDLKLGNLFLNDLLHVKIGDFGLATRIEYEGERKKTLCGTPNYIAPEILTK 197
            :.|::|||..||:|||||..|.|||..:.|||||.|||.|:...|...:.||||||:.|||::::
Mouse   148 VSGLRYLHQQRIVHRDLKPSNFFLNKNMEVKIGDLGLAARVGPAGRCHRVLCGTPNFQAPEVVSR 212

  Fly   198 KGHSFEVDIWSIGCVMYTLLVGQPPFETKTLKDTYSKIKKCEYRVPSYLRKPAADMVIAMLQPNP 262
            .|||.:.|||::||:|||:|.|.|||....|.:.|..|:...|..|::|...|..::..:|.|:|
Mouse   213 NGHSCKSDIWALGCIMYTVLTGTPPFAAAPLSEMYQNIRDGHYLEPTHLSPSARSLIARLLAPDP 277

  Fly   263 ESRPAIGQLLNFEFLKGSKVPMFL-PSSC-----LTMAPRIGSNDTIEDSMHRK----------- 310
            ..||::..||..:|......|..| |.||     ....|.:|       .:.||
Mouse   278 AERPSLDHLLQDDFFSQGFTPERLPPHSCHSPPVFAFPPPLG-------RLFRKVGQLLLTQCRP 335

  Fly   311 --PLMEMNGIRPDDTRLESTFLKANLHDAITASAQVCRHSEDYRSDIESLYQQLTNLINGKPRI- 372
              |........|.:...|...::|...:    ...:|...   |..:.:|....|.|...|..:
Mouse   336 PCPFTSKEASGPGEEGTEPDHMEAGNEE----RDPLCTEG---RIHLLTLGTPRTGLAGPKGSLA 393

  Fly   373 LQ--------------GNLGDENTDPAAQPLFWISKWVDYSDKYGFGYQLCDEGIGVMFNDTTKL 423
            ||              |.:..::.....:|:.|..||||||.||||||||.|.|.||:|.|.:.:
Mouse   394 LQLEVATRKLFLCLDAGPMAGQDPPGEQRPVLWAPKWVDYSLKYGFGYQLSDGGSGVLFRDGSHM 458

  Fly   424 ILLPNQINVHFIDKDGKETYMTTTDYCKSLDKKMKLLSYFKRYMIEHLVKAGANNVNIESDQISR 488
            .|.|...:|.:....|.....|..|....|..|:.:|..|..||...|.:.|  .|.:.:...|.
Mouse   459 ALRPQGGHVSYQPDQGTLWTFTLRDVPSPLRAKLAVLRLFACYMQRRLREEG--TVPMPATPASP 521

  Fly   489 MPHLHSWFRTTCAVVMHLTNGSVQLNF-SDHMKLILCPRMSAITYMDQEKNFR----TYRFSTIV 548
            ...|.|:...:.|:||..:||:||::. :...:|:|......:....||....    :|....:.
Mouse   522 DISLLSFIADSQAMVMLFSNGTVQVSLKTSQTQLVLSGEDEDLLLTLQEPGGPAVGVSYTLDVLR 586

  Fly   549 ENGVSKDLYQKIRYAQEKLRKM 570
            .:|.:..::..:|:....|:.:
Mouse   587 SHGFTLAVHHHLRHGLHLLQSV 608

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
polo	NP_524179.2	STKc_PLK	23..277	CDD:271001	106/266 (40%)
		POLO_box_1	388..475	CDD:240561	35/86 (41%)
		POLO_box_2	490..570	CDD:240560	17/84 (20%)
Plk5	NP_001420485.1	STKc_PLK	25..292	CDD:271001	106/266 (40%)
		POLO_box_1	423..510	CDD:240561	35/86 (41%)