Protein Alignment polo and Plk4

DIOPT Version :10

• Sequence 1: NP_524179.2
• Gene: polo / 40232
• FlyBaseID: FBgn0003124
• Length: 576
• Species: Drosophila melanogaster
• Sequence 2: NP_001397550.1
• Gene: Plk4 / 20873
• MGIID: 101783
• Length: 926
• Species: Mus musculus
• Alignment Length: 515
• Identity: 154/515 - (29%)
• Similarity: 243/515 - (47%)
• Gaps: 101/515 - (19%)

  Fly    25 YKRMRFFGKGGFAKCYEIIDVETDDVFAGKIVSKKLMIKHNQKEKTAQEITIHRSLNHPNIVKFH 89
            :|.....|||.||..|....:.|....|.|::.||.|.|....::...|:.||..|.||::::.:
Mouse    13 FKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPSVLELY 77

  Fly    90 NYFEDSQNIYIVLELCKKRSMME-LHKRRKSITEFECRYYIYQIIQGVKYLHDNRIIHRDLKLGN 153
            |||||:..:|:|||:|....|.. |..|.|..:|.|.|::::|||.|:.|||.:.|:||||.|.|
Mouse    78 NYFEDNNYVYLVLEMCHNGEMNRYLKNRMKPFSEREARHFMHQIITGMLYLHSHGILHRDLTLSN 142

  Fly   154 LFLNDLLHVKIGDFGLATRIEYEGERKKTLCGTPNYIAPEILTKKGHSFEVDIWSIGCVMYTLLV 218
            :.|...:::||.||||||::....|:..|||||||||:|||.|:..|..|.||||:||:.||||:
Mouse   143 ILLTRNMNIKIADFGLATQLNMPHEKHYTLCGTPNYISPEIATRSAHGLESDIWSLGCMFYTLLI 207

  Fly   219 GQPPFETKTLKDTYSKIKKCEYRVPSYLRKPAADMVIAMLQPNPESRPAIGQLLNFEFLKGSKVP 283
            |:|||:|.|:|:|.:|:...:|.:|::|.:.|.|::..:|:.||..|.::..:|:..|:  |:.|
Mouse   208 GRPPFDTDTVKNTLNKVVLADYEMPAFLSREAQDLIHQLLRRNPADRLSLSSVLDHPFM--SRNP 270

  Fly   284 MFLPSSCLTMAPRIGSNDTIEDSMHRKPLMEMNGIRPDDTRLESTFLKANLHDAITASAQVCRHS 348
                      :|:.....|:||||.       :|             .|.|...||||:..
Mouse   271 ----------SPKSKDVGTVEDSMD-------SG-------------HATLSTTITASSGT---- 301

  Fly   349 EDYRSDIESLYQQLTN--LINGKP-----RILQGNLGDENTDPAAQPLFWISKWVDYSDKYGFGY 406
                    ||...|.:  |:.|:|     .:.|.|   :|:.             |:|.  |.|.
Mouse   302 --------SLSGSLLDRRLLVGQPLPNKITVFQKN---KNSS-------------DFSS--GDGS 340

  Fly   407 QLCDE-----------GIGVMFNDTTKLILLPNQINVHFIDKDGKETYMTTTDYCKSLDKKMKLL 460
            ..|.:           |.|.:..|..:..........|..|:...........|.......:::|
Mouse   341 NFCTQWGNPEQEANSRGRGRVIEDAEERPHSRYLRRAHSSDRASPSNQSRAKTYSVERCHSVEML 405

  Fly   461 SYFKRYMIEHLVKAGANNVNIE------SDQISRMPHLHSWFRTTCAVVMHLTNGSVQLN 514
            |..:|.:.|:  :..:|:..:.      :||..:|..:..||            |::|:|
Mouse   406 SKPRRSLDEN--QHSSNHHCLGKTPFPFADQTPQMEMVQQWF------------GNLQMN 451

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
polo	NP_524179.2	STKc_PLK	23..277	CDD:271001	105/252 (42%)
		POLO_box_1	388..475	CDD:240561	15/97 (15%)
		POLO_box_2	490..570	CDD:240560	5/25 (20%)
Plk4	NP_001397550.1	STKc_PLK4	11..266	CDD:271088	105/252 (42%)
		Plk4_PB1	553..659	CDD:465672
		POLO_box_Plk4_2	661..769	CDD:240558
		POLO_box_Plk4_3	840..919	CDD:240559