DRSC/TRiP Functional Genomics Resources

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Protein Alignment polo and Plk2

DIOPT Version :10

Sequence 1:NP_524179.2 Gene:polo / 40232 FlyBaseID:FBgn0003124 Length:576 Species:Drosophila melanogaster
Sequence 2:NP_690017.2 Gene:Plk2 / 20620 MGIID:1099790 Length:682 Species:Mus musculus


Alignment Length:623 Identity:225/623 - (36%)
Similarity:353/623 - (56%) Gaps:77/623 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly    16 LVDINQRKTYKRMRFFGKGGFAKCYEIIDVETDDVFAGKIVSKKLMIKHNQKEKTAQEITIHRSL 80
            :||....|.|.|.:..||||||||||:.|:..:.|:|.||:....:.|.:|:||..:||.:||.|
Mouse    70 IVDPTTGKRYCRGKVLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVAKPHQREKIDKEIELHRLL 134

  Fly    81 NHPNIVKFHNYFEDSQNIYIVLELCKKRSMMELHKRRKSITEFECRYYIYQIIQGVKYLHDNRII 145
            :|.::|:|::||||.:||||:||.|.:|||..:.|.||.:||.|.|||:.||:.|:||||:..|:
Mouse   135 HHKHVVQFYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEIL 199

  Fly   146 HRDLKLGNLFLNDLLHVKIGDFGLATRIEYEGERKKTLCGTPNYIAPEILTKKGHSFEVDIWSIG 210
            ||||||||.|:|:.:.:|:||||||.|:|....|::|:||||||::||:|.|:||..|.|||::|
Mouse   200 HRDLKLGNFFINEAMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQGHGCESDIWALG 264

  Fly   211 CVMYTLLVGQPPFETKTLKDTYSKIKKCEYRVPSYLRKPAADMVIAMLQPNPESRPAIGQLLNFE 275
            |||||:|:|:|||||..||:||..|::..|.:||.|..||..::.:||..|||.||::..::..:
Mouse   265 CVMYTMLLGRPPFETTNLKETYRCIREARYTMPSSLLAPAKHLIASMLSKNPEDRPSLDDIIRHD 329

  Fly   276 FLKGSKVPMFLPSSCLTMAPRIGSNDTIEDSMHRKPLMEMNGIRPDDTRLESTFLKANLHD---- 336
            |......|..|.|||....|....:...: :..:|....:.|.:.|..|...|..|.:..|    
Mouse   330 FFLQGFTPDRLSSSCCHTVPDFHLSSPAK-NFFKKAAAALFGGKKDKARYNDTHNKVSKEDEDIY 393

  Fly   337 -------AITASAQVCRHSEDYR-------------SDIESLYQQLTNLINGKPRILQGNLG--- 378
                   .::.:.|..:|..|..             |.:|: .||:.:.|.   .|::|.||   
Mouse   394 KLRHDLKKVSITQQPSKHRADEEPQPPPTTVARSGTSAVEN-KQQIGDAIR---MIVRGTLGSCS 454

  Fly   379 ------DENT-----DPAAQPL----------------------FWISKWVDYSDKYGFGYQLCD 410
                  :::|     |..|:.|                      .|::||||||:||||||||.|
Mouse   455 SSSECLEDSTMGSVADTVARVLRGCLENMPEADCIPKEQLSTSFQWVTKWVDYSNKYGFGYQLSD 519

  Fly   411 EGIGVMFNDTTKLILLPNQINVHFIDKDGKETYMTTTDYCKSLDKKMKLLSYFKRYMIEHLVKAG 475
            ..:||:||:...:.|||::..||:..:.|:.:....||..:....::.:|.||..||.|:|:..|
Mouse   520 HTVGVLFNNGAHMSLLPDKKTVHYYAELGQCSVFPATDAPEQFISQVTVLKYFSHYMEENLMDGG 584

  Fly   476 ANNVNIESDQISRMPHLH--SWFRTTCAVVMHLTNGSVQLNF-SDHMKLILCPRMS--AITYMDQ 535
                ::.|....|.|.|:  .|.::..|::|...:|:.|:|| .||.|:|:|.:..  .:||:::
Mouse   585 ----DLPSVTDIRRPRLYLLQWLKSDKALMMLFNDGTFQVNFYHDHTKIIICNQSEEYLLTYINE 645

  Fly   536 EKNFRTYRFSTIVENGVSKDLYQKIRYAQEKLRKMLEK 573
            ::...|:|.:|::.:|.|.:|..::.||   |..:|::
Mouse   646 DRISTTFRLTTLLMSGCSLELKNRMEYA---LNMLLQR 680

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
poloNP_524179.2 STKc_PLK 23..277 CDD:271001 129/253 (51%)
POLO_box_1 388..475 CDD:240561 36/108 (33%)
POLO_box_2 490..570 CDD:240560 25/84 (30%)
Plk2NP_690017.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 25..67
STKc_PLK2 77..331 CDD:271090 129/253 (51%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 403..432 4/28 (14%)
POLO_box_1 500..585 CDD:240561 36/88 (41%)
POLO_box_2 598..679 CDD:240560 23/83 (28%)
Blue background indicates that the domain is not in the aligned region.

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