| Sequence 1: | NP_001014592.1 | Gene: | polo / 40232 | FlyBaseID: | FBgn0003124 | Length: | 576 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_035251.3 | Gene: | Plk1 / 18817 | MGIID: | 97621 | Length: | 603 | Species: | Mus musculus |
| Alignment Length: | 570 | Identity: | 305/570 - (53%) |
|---|---|---|---|
| Similarity: | 415/570 - (72%) | Gaps: | 26/570 - (4%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 11 DIPDRLVDINQRKTYKRMRFFGKGGFAKCYEIIDVETDDVFAGKIVSKKLMIKHNQKEKTAQEIT 75
Fly 76 IHRSLNHPNIVKFHNYFEDSQNIYIVLELCKKRSMMELHKRRKSITEFECRYYIYQIIQGVKYLH 140
Fly 141 DNRIIHRDLKLGNLFLNDLLHVKIGDFGLATRIEYEGERKKTLCGTPNYIAPEILTKKGHSFEVD 205
Fly 206 IWSIGCVMYTLLVGQPPFETKTLKDTYSKIKKCEYRVPSYLRKPAADMVIAMLQPNPESRPAIGQ 270
Fly 271 LLNFEFLKGSKVPMFLPSSCLTMAPRIGSNDTIEDSMHRKPLMEMN-GIR---PDDTRLESTFLK 331
Fly 332 ANLHDAITASAQVCRHSEDYRSDIESLYQQLTNLINGKPR----ILQGNLGDENTDPAAQPLFWI 392
Fly 393 SKWVDYSDKYGFGYQLCDEGIGVMFNDTTKLILLPNQINVHFIDKDGKETYMTTTDYCKSLDKKM 457
Fly 458 KLLSYFKRYMIEHLVKAGANNVNIESDQISRMPHLHSWFRTTCAVVMHLTNGSVQLN-FSDHMKL 521
Fly 522 ILCPRMSAITYMDQEKNFRTYRFSTIVENGVSKDLYQKIRYAQEKLRKML 571 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| polo | NP_001014592.1 | STKc_PLK | 23..277 | CDD:271001 | 166/253 (66%) |
| POLO_box_1 | 388..475 | CDD:240561 | 49/86 (57%) | ||
| POLO_box_2 | 490..570 | CDD:240560 | 39/80 (49%) | ||
| Plk1 | NP_035251.3 | STKc_PLK1 | 45..309 | CDD:271089 | 170/263 (65%) |
| S_TKc | 53..305 | CDD:214567 | 166/251 (66%) | ||
| Activation loop. /evidence=ECO:0000250 | 194..221 | 24/26 (92%) | |||
| D-box that targets the protein for proteasomal degradation in anaphase. /evidence=ECO:0000250 | 337..340 | 2/2 (100%) | |||
| POLO_box_1 | 407..494 | CDD:240561 | 49/86 (57%) | ||
| Linker. /evidence=ECO:0000250 | 493..507 | 6/13 (46%) | |||
| POLO_box_2 | 509..590 | CDD:240560 | 39/80 (49%) | ||
| Important for interaction with phosphorylated proteins. /evidence=ECO:0000250 | 538..540 | 1/1 (100%) |
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 1 | 0.930 | - | - | C167850245 | |
| Domainoid | 1 | 1.000 | 361 | 1.000 | Domainoid score | I947 |
| eggNOG | 1 | 0.900 | - | - | E1_KOG0575 | |
| Hieranoid | 1 | 1.000 | - | - | ||
| Homologene | 1 | 1.000 | - | - | H3690 | |
| Inparanoid | 1 | 1.050 | 617 | 1.000 | Inparanoid score | I889 |
| Isobase | 1 | 0.950 | - | 0 | Normalized mean entropy | S1212 |
| OMA | 1 | 1.010 | - | - | QHG54080 | |
| OrthoDB | 1 | 1.010 | - | - | D373288at33208 | |
| OrthoFinder | 1 | 1.000 | - | - | FOG0000754 | |
| OrthoInspector | 1 | 1.000 | - | - | oto93206 | |
| orthoMCL | 1 | 0.900 | - | - | OOG6_100759 | |
| Panther | 1 | 1.100 | - | - | LDO | PTHR24345 |
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 1 | 1.030 | - | avgDist | Average_Evolutionary_Distance | R930 |
| SonicParanoid | 1 | 1.000 | - | - | X638 | |
| SwiftOrtho | 1 | 1.000 | - | - | ||
| TreeFam | 1 | 0.960 | - | - | ||
| 18 | 17.750 | |||||