Protein Alignment polo and plk-1

DIOPT Version :9

• Sequence 1: NP_001014592.1
• Gene: polo / 40232
• FlyBaseID: FBgn0003124
• Length: 576
• Species: Drosophila melanogaster
• Sequence 2: NP_001021173.1
• Gene: plk-1 / 176143
• WormBaseID: WBGene00004042
• Length: 648
• Species: Caenorhabditis elegans
• Alignment Length: 607
• Identity: 270/607 - (44%)
• Similarity: 379/607 - (62%)
• Gaps: 57/607 - (9%)

  Fly     3 AKPEDKST--------DIPDRLVDINQRKTYKRMRFFGKGGFAKCYEIIDVETDDVFAGKIVSKK 59
            |||..||.        ::|..:.|.::...|::.||.||||||.|||:.:..|.:|.|||:|.|.
 Worm     8 AKPPQKSNQRKEKAPPEVPALIADKDRGTYYEKGRFLGKGGFAHCYELTNRATREVVAGKVVPKS 72

  Fly    60 LMIKHNQKEKTAQEITIHRSLNHPNIVKFHNYFEDSQNIYIVLELCKKRSMMELHKRRKSITEFE 124
            :::|..|::|..||:.|||.|.|.||||..|:|||:.|:||.||||.:||:||||||||::||.|
 Worm    73 MLVKQYQRDKMTQEVQIHRELGHINIVKLFNFFEDNLNVYITLELCARRSLMELHKRRKAVTEPE 137

  Fly   125 CRYYIYQIIQGVKYLHDNRIIHRDLKLGNLFLNDLLHVKIGDFGLATRIEYEGERKKTLCGTPNY 189
            .||:.:||:.||.||||..|||||:|||||||||.|.||||||||||.:..: ||||||||||||
 Worm   138 ARYFTHQIVDGVLYLHDLNIIHRDMKLGNLFLNDDLVVKIGDFGLATTVNGD-ERKKTLCGTPNY 201

  Fly   190 IAPEILTKKGHSFEVDIWSIGCVMYTLLVGQPPFETKTLKDTYSKIKKCEYRVPSYLRKPAADMV 254
            ||||:|.|.|||||||||::||::|.||.||||||:|:|::|||:|:...|.:||...:|||.::
 Worm   202 IAPEVLNKAGHSFEVDIWAVGCILYILLFGQPPFESKSLEETYSRIRHNNYTIPSIATQPAASLI 266

  Fly   255 IAMLQPNPESRPAIGQLLNFEFLKGSKVPMFLPSSCLTMAPRIGSNDT--IE--------DSMHR 309
            ..||.|.|..||...|:....|.|...:|..||.|||||.|:.|.::|  :|        |:..:
 Worm   267 RKMLDPEPTRRPTAKQVQRDGFFKSGFMPTRLPVSCLTMVPKFGGHETSMMEENVAPRGVDARSQ 331

  Fly   310 KPLMEMNGI---------------RPDDTRLESTFLKANLHDAITASAQVCRHSEDYRSDIESLY 359
            :||....|:               |......|:||                |..||  :.:..|:
 Worm   332 RPLNGRAGLSALPQHIVSNNADRERAQQQAAEATF----------------REPED--AYLSQLF 378

  Fly   360 QQLTNLINGK-PRILQGNLG-DENTDPAAQPLFWISKWVDYSDKYGFGYQLCDEGIGVMFNDTTK 422
            .|:..|:..: |.:.:.... |....|...|:||||||||||||||.||||||..:||:|||.::
 Worm   379 HQVAVLLEQRIPGLEEEEAALDGYQSPECLPVFWISKWVDYSDKYGIGYQLCDNSVGVLFNDNSR 443

  Fly   423 LILLPNQINVHFIDKDGKETY--MTTTDYCKSLDKKMKLLSYFKRYMIEHLVKAGANNVNIESDQ 485
            ::|......:.:|:|..||.|  |.:.:....|:||:.||.||:.||.:||||||..:.....|.
 Worm   444 IMLDQAGNELTYIEKSNKEHYFSMHSGEMPGLLNKKVTLLKYFRSYMNDHLVKAGEGSEQRAGDD 508

  Fly   486 ISRMPHLHSWFRTTCAVVMHLTNGSVQLN-FSDHMKLILCPRMSAITYMDQEKNFRTYRFSTIVE 549
            ::|:|.|..||||..|:|:||:||:||:| |:||:|:::||.|.|:|::||.|...||:.:.:..
 Worm   509 LARLPTLRVWFRTKSAIVLHLSNGTVQINFFNDHVKMMMCPLMQAVTFIDQNKRMLTYKLNNLQR 573

  Fly   550 NGVSKDLYQKIRYAQEKLRKML 571
            ||..:....:::||:..:.:::
 Worm   574 NGCPEKFLHRLKYAKTMIERLM 595

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
polo	NP_001014592.1	STKc_PLK	23..277	CDD:271001	149/253 (59%)
		POLO_box_1	388..475	CDD:240561	46/88 (52%)
		POLO_box_2	490..570	CDD:240560	33/80 (41%)
plk-1	NP_001021173.1	STKc_PLK	36..289	CDD:271001	149/253 (59%)
		S_TKc	38..289	CDD:214567	149/251 (59%)
		POLO_box_1	409..499	CDD:240561	47/89 (53%)
		POLO_box_2	513..594	CDD:240560	33/80 (41%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	315	1.000	Domainoid score	I691
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3690
Inparanoid	1	1.050	526	1.000	Inparanoid score	I671
Isobase	1	0.950	-	0	Normalized mean entropy	S1212
OMA	1	1.010	-	-		QHG54080
OrthoDB	1	1.010	-	-		D373288at33208
OrthoFinder	1	1.000	-	-		FOG0000754
OrthoInspector	1	1.000	-	-		otm14095
orthoMCL	1	0.900	-	-		OOG6_100759
Panther	1	1.100	-	-	O	PTHR24345
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R930
SonicParanoid	1	1.000	-	-		X638
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.960