Protein Alignment polo and PLK5

DIOPT Version :10

• Sequence 1: NP_524179.2
• Gene: polo / 40232
• FlyBaseID: FBgn0003124
• Length: 576
• Species: Drosophila melanogaster
• Sequence 2: NP_001230008.1
• Gene: PLK5 / 126520
• HGNCID: 27001
• Length: 336
• Species: Homo sapiens
• Alignment Length: 237
• Identity: 72/237 - (30%)
• Similarity: 102/237 - (43%)
• Gaps: 50/237 - (21%)

  Fly   213 MYTLLVGQPPFETKTLKDTYSKIKKCEYRVPSYLRKPAADMVIAMLQPNPESRPAIGQLLNFEFL 277
            |||:|.|.|||....|.:.|..|::..|..|::|...|..:::.:|.|||..||::..||..:|.
Human     1 MYTVLTGTPPFMASPLSEMYQNIREGHYPEPAHLSANARRLIVHLLAPNPAERPSLDHLLQDDFF 65

  Fly   278 KGSKVPMFLPS-SC-----LTMAPRIGSNDTIEDSMHRK-------------PL--MEMNGI--- 318
            .....|..||: ||     ..:.|.:|       .:.||             |.  .|.:|.
Human    66 TQGFTPDRLPAHSCHSPPIFAIPPPLG-------RIFRKVGQRLLTQCRPPCPFTPKEASGPGEG 123

  Fly   319 RPDDTRLE---STFLKAN----LHDAITASAQVCRHSE------DYRSDIESLYQQLTNLINGKP 370
            .||...:|   .:.|.|.    |...|...||....|:      ..|.::|:..:.|...::..|
Human   124 GPDPDSMEWDGESSLSAKEVPCLEGPIHLVAQGTLQSDLAGPEGSRRPEVEAALRHLQLCLDVGP 188

  Fly   371 RILQGNLGDENTDPAAQPLFWISKWVDYSDKYGFGYQLCDEG 412
            ...|..||::      ||:.|..||||||.||||||||.|.|
Human   189 PATQDPLGEQ------QPILWAPKWVDYSSKYGFGYQLLDGG 224

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
polo	NP_524179.2	STKc_PLK	23..277	CDD:271001	23/63 (37%)
		POLO_box_1	388..475	CDD:240561	18/25 (72%)
		POLO_box_2	490..570	CDD:240560
PLK5	NP_001230008.1	SPS1	<1..287	CDD:440281	72/237 (30%)
		Protein Kinases, catalytic domain	<1..65	CDD:473864	23/63 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	109..135		6/25 (24%)
		POLO_box_1	200..275	CDD:240561	18/25 (72%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	224..245		1/1 (100%)
		POLO_box	255..336	CDD:470700