DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment polo and PLK3

DIOPT Version :9

Sequence 1:	NP_001014592.1	Gene:	polo / 40232	FlyBaseID:	FBgn0003124	Length:	576	Species:	Drosophila melanogaster
Sequence 2:	NP_004064.2	Gene:	PLK3 / 1263	HGNCID:	2154	Length:	646	Species:	Homo sapiens

Alignment Length:	616	Identity:	231/616 - (37%)
Similarity:	339/616 - (55%)	Gaps:	77/616 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 TDIPDRLV-DINQRKTYKRMRFFGKGGFAKCYEIIDVETDDVFAGKIVSKKLMIKHNQKEKTAQE 73
            |..|.||: |....:||.:.|..||||||:|||..|.||...:|.|::.:..:.|.:|:||...|
Human    46 TSDPGRLITDPRSGRTYLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNE 110

  Fly    74 ITIHRSLNHPNIVKFHNYFEDSQNIYIVLELCKKRSMMELHKRRKSITEFECRYYIYQIIQGVKY 138
            |.:||.|.|.:||:|.::|||:.||||.||||.::|:..:.|.|.::.|.|.|||:.||:.|:||
Human   111 IELHRDLQHRHIVRFSHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKY 175

  Fly   139 LHDNRIIHRDLKLGNLFLNDLLHVKIGDFGLATRIEYEGERKKTLCGTPNYIAPEILTKKGHSFE 203
            ||...|:||||||||.|:.:.:.:|:||||||.|:|...:||||:||||||:|||:|.::||..|
Human   176 LHQRGILHRDLKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQGHGPE 240

  Fly   204 VDIWSIGCVMYTLLVGQPPFETKTLKDTYSKIKKCEYRVPSYLRKPAADMVIAMLQPNPESRPAI 268
            .|:||:||||||||.|.|||||..||:||..||:..|.:|:.|..||..::.|:|:.:|..||:|
Human   241 ADVWSLGCVMYTLLCGSPPFETADLKETYRCIKQVHYTLPASLSLPARQLLAAILRASPRDRPSI 305

  Fly   269 GQLLNFEFLKGSKVPMFLP-SSCLTMAPRIGSNDT------IEDSM---------HRKPLMEMNG 317
            .|:|..:|......|..|| |||:|:......|..      :..|:         |.:...|::|
Human   306 DQILRHDFFTKGYTPDRLPISSCVTVPDLTPPNPARSLFAKVTKSLFGRKKKSKNHAQERDEVSG 370

  Fly   318 I--------------------------------RPDDTRLESTFLKA--NLHDAITASAQVCRHS 348
            :                                .|:|:....|...:  ...:.:|.:..|
Human   371 LVSGLMRTSVGHQDARPEAPAASGPAPVSLVETAPEDSSPRGTLASSGDGFEEGLTVATVV---- 431

  Fly   349 EDYRSDIESLYQQLTNLINGKPRILQGNLGDENTDPAAQ--PLFWISKWVDYSDKYGFGYQLCDE 411
                   ||....|.|.|...|.      .::|..|.||  ||.|:|||||||:|:||||||...
Human   432 -------ESALCALRNCIAFMPP------AEQNPAPLAQPEPLVWVSKWVDYSNKFGFGYQLSSR 483

  Fly   412 GIGVMFNDTTKLILLPNQINVHFIDKDGKETYMTTTDYCKSLDKKMKLLSYFKRYMIEHLVKAGA 476
            .:.|:|||.|.:.|..|:..||:.....|....:.....::|..::.:|.||..||.:||:| |.
Human   484 RVAVLFNDGTHMALSANRKTVHYNPTSTKHFSFSVGAVPRALQPQLGILRYFASYMEQHLMK-GG 547

  Fly   477 NNVNIESDQISRMPHLHSWFRTTCAVVMHLTNGSVQLNF-SDHMKLILC---PRMSAITYMDQEK 537
            :..::|..::...|.|..|.:|..|::|..::|:||:|| .||.||||.   |.:  :|::.:.:
Human   548 DLPSVEEVEVPAPPLLLQWVKTDQALLMLFSDGTVQVNFYGDHTKLILSGWEPLL--VTFVARNR 610

  Fly   538 NFRTYRFSTIVENGVSKDLYQKIRYAQEKLR 568
            :..||..|.:.:.|.|.||.|::|||...||
Human   611 SACTYLASHLRQLGCSPDLRQRLRYALRLLR 641

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
polo	NP_001014592.1	STKc_PLK	23..277	CDD:271001	128/253 (51%)
		POLO_box_1	388..475	CDD:240561	36/86 (42%)
		POLO_box_2	490..570	CDD:240560	32/83 (39%)
PLK3	NP_004064.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..35
		STKc_PLK3	60..314	CDD:271091	128/253 (51%)
		S_TKc	62..314	CDD:214567	127/251 (51%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	381..417		3/35 (9%)
		POLO_box_1	460..548	CDD:240561	37/88 (42%)
		POLO_box_2	561..628	CDD:240560	24/68 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0575
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D373288at33208
OrthoFinder	1	1.000	-	-		FOG0000754
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100759
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R930
SonicParanoid	1	1.000	-	-		X638
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.750