DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment polo and PLK2

DIOPT Version :10

Sequence 1:NP_524179.2 Gene:polo / 40232 FlyBaseID:FBgn0003124 Length:576 Species:Drosophila melanogaster
Sequence 2:NP_006613.2 Gene:PLK2 / 10769 HGNCID:19699 Length:685 Species:Homo sapiens


Alignment Length:619 Identity:222/619 - (35%)
Similarity:351/619 - (56%) Gaps:69/619 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly    16 LVDINQRKTYKRMRFFGKGGFAKCYEIIDVETDDVFAGKIVSKKLMIKHNQKEKTAQEITIHRSL 80
            :||....|.|.|.:..||||||||||:.|:..:.|:|.||:....:.|.:|:||..:||.:||.|
Human    73 IVDPTTGKRYCRGKVLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVAKPHQREKIDKEIELHRIL 137

  Fly    81 NHPNIVKFHNYFEDSQNIYIVLELCKKRSMMELHKRRKSITEFECRYYIYQIIQGVKYLHDNRII 145
            :|.::|:|::||||.:||||:||.|.:|||..:.|.||.:||.|.|||:.||:.|:||||:..|:
Human   138 HHKHVVQFYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEIL 202

  Fly   146 HRDLKLGNLFLNDLLHVKIGDFGLATRIEYEGERKKTLCGTPNYIAPEILTKKGHSFEVDIWSIG 210
            ||||||||.|:|:.:.:|:||||||.|:|....|::|:||||||::||:|.|:||..|.|||::|
Human   203 HRDLKLGNFFINEAMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQGHGCESDIWALG 267

  Fly   211 CVMYTLLVGQPPFETKTLKDTYSKIKKCEYRVPSYLRKPAADMVIAMLQPNPESRPAIGQLLNFE 275
            |||||:|:|:|||||..||:||..|::..|.:||.|..||..::.:||..|||.||::..::..:
Human   268 CVMYTMLLGRPPFETTNLKETYRCIREARYTMPSSLLAPAKHLIASMLSKNPEDRPSLDDIIRHD 332

  Fly   276 FLKGSKVPMFLPSSCLTMAPRIGSNDTIEDSMHRKPLMEMNGIRPDDTRLESTFLKANLHD---- 336
            |......|..|.|||....|....:...: :..:|....:.|.:.|..|...|..:.:..|    
Human   333 FFLQGFTPDRLSSSCCHTVPDFHLSSPAK-NFFKKAAAALFGGKKDKARYIDTHNRVSKEDEDIY 396

  Fly   337 ---------AITASAQVCRHSEDYRSDIESLYQQLTNLINGKPR-------ILQGNLG------- 378
                     :||......|..|:.:....::.:..|..:..|.:       |::|.||       
Human   397 KLRHDLKKTSITQQPSKHRTDEELQPPTTTVARSGTPAVENKQQIGDAIRMIVRGTLGSCSSSSE 461

  Fly   379 --DENT-----DPAAQPL----------------------FWISKWVDYSDKYGFGYQLCDEGIG 414
              :::|     |..|:.|                      .|::||||||:||||||||.|..:|
Human   462 CLEDSTMGSVADTVARVLRGCLENMPEADCIPKEQLSTSFQWVTKWVDYSNKYGFGYQLSDHTVG 526

  Fly   415 VMFNDTTKLILLPNQINVHFIDKDGKETYMTTTDYCKSLDKKMKLLSYFKRYMIEHLVKAGANNV 479
            |:||:...:.|||::..||:..:.|:.:....||..:....::.:|.||..||.|:|:..|    
Human   527 VLFNNGAHMSLLPDKKTVHYYAELGQCSVFPATDAPEQFISQVTVLKYFSHYMEENLMDGG---- 587

  Fly   480 NIESDQISRMPHLH--SWFRTTCAVVMHLTNGSVQLNF-SDHMKLILCPRMS--AITYMDQEKNF 539
            ::.|....|.|.|:  .|.::..|::|...:|:.|:|| .||.|:|:|.:..  .:||:::::..
Human   588 DLPSVTDIRRPRLYLLQWLKSDKALMMLFNDGTFQVNFYHDHTKIIICSQNEEYLLTYINEDRIS 652

  Fly   540 RTYRFSTIVENGVSKDLYQKIRYAQEKLRKMLEK 573
            .|:|.:|::.:|.|.:|..::.||   |..:|::
Human   653 TTFRLTTLLMSGCSSELKNRMEYA---LNMLLQR 683

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
poloNP_524179.2 STKc_PLK 23..277 CDD:271001 129/253 (51%)
POLO_box_1 388..475 CDD:240561 36/108 (33%)
POLO_box_2 490..570 CDD:240560 25/84 (30%)
PLK2NP_006613.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 21..70
STKc_PLK2 80..334 CDD:271090 129/253 (51%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 406..433 4/26 (15%)
POLO_box_1 503..588 CDD:240561 36/88 (41%)
POLO_box_2 601..682 CDD:240560 23/83 (28%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.