DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LPL and CG6295

DIOPT Version :9

Sequence 1:	NP_000228.1	Gene:	LPL / 4023	HGNCID:	6677	Length:	475	Species:	Homo sapiens
Sequence 2:	NP_651521.1	Gene:	CG6295 / 43247	FlyBaseID:	FBgn0039471	Length:	338	Species:	Drosophila melanogaster

Alignment Length:	295	Identity:	91/295 - (30%)
Similarity:	132/295 - (44%)	Gaps:	53/295 - (17%)

- Green bases have known domain annotations that are detailed below.

Human    57 IPGVAESVATCHFNHSSKTFMVIHGWTVT-------GMYESWVPKLVAALYKREPDSNVIVVDWL 114
            |...:.|::..|||.:..|...||||:.:       |:.::|.         ...|.|:|.|||.
  Fly    80 IKATSASISGSHFNPNHPTRFTIHGWSSSKDEFINYGVRDAWF---------THGDMNMIAVDWG 135

Human   115 SRAQEHYPVSAGYTKLVGQDVARFINWMEEEFNYPLDNVHLLGYSLGAHAAGIAG-SLTNKKVNR 178
            ......|..|......||:.||..||:|.......|||..::|:|||||.:|.|| ::.|.:::.
  Fly   136 RARSVDYASSVLAVPGVGEQVATLINFMRSNHGLNLDNTMVIGHSLGAHVSGYAGKNVKNGQLHT 200

Human   179 ITGLDPAGPNFEYAEAPSRLSPDDADFVDVLHTFTRGSPGRSIGIQKPVGHVDIYPNGGTFQPGC 243
            |.|||||.|.|.|.....|||..||.:|:.:.|     .|.::|..||:|....|||||..||||
  Fly   201 IIGLDPALPLFSYDSPNKRLSSTDAYYVESIQT-----NGGTLGFLKPIGKGAFYPNGGKSQPGC 260

Human   244 NIGEAIRVIAERGLGDVDQLVKCSHERSIHLFIDSLLNEENPSKAYRCSSKEAFEKGLCLSCRKN 308
            .               ||....|:|.||:..:.:|:  .||.....||..   :|:.:...|..:
  Fly   261 G---------------VDLTGSCAHSRSVIYYAESV--TENNFPTMRCGD---YEEAVAKECGSS 305

Human   309 RCNNLGYEINKVRAKRSSKM-----YLKTRSQMPY 338
                  |...::.|..::.|     |:..||..||
  Fly   306 ------YSSVRMGATTNAYMVAGDYYVPVRSDAPY 334

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LPL	NP_000228.1	Interaction with GPIHBP1. /evidence=ECO:0000269\|PubMed:30559189	32..53
		Lipase	33..473	CDD:332983	91/295 (31%)
		Essential for determining substrate specificity. /evidence=ECO:0000269\|PubMed:7592706	243..266		3/22 (14%)
		Important for interaction with lipoprotein particles. /evidence=ECO:0000269\|PubMed:27929370	417..421
		Important for heparin binding. /evidence=ECO:0000269\|PubMed:11342582	430..434
		Interaction with GPIHBP1. /evidence=ECO:0000269\|PubMed:26725083, ECO:0000269\|PubMed:30559189	443..467
CG6295	NP_651521.1	Pancreat_lipase_like	64..330	CDD:238363	87/289 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145308
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11610
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.940