DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pex23 and TECPR2

DIOPT Version :9

Sequence 1:NP_730508.1 Gene:Pex23 / 40229 FlyBaseID:FBgn0052226 Length:1350 Species:Drosophila melanogaster
Sequence 2:NP_055659.2 Gene:TECPR2 / 9895 HGNCID:19957 Length:1411 Species:Homo sapiens


Alignment Length:1490 Identity:292/1490 - (19%)
Similarity:480/1490 - (32%) Gaps:525/1490 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   105 GVDKIRLPSMAWQ------WDGD-----WHLDLELDGQPLTEDGWMYALDFPAT-----YSAKKS 153
            |:.|..:.::||.      :.||     .:..|:|| |.|...  ...|:.|::     ||.|..
Human   124 GIHKNSITALAWSPNGMKLFSGDDKGKIVYSSLDLD-QGLCNS--QLVLEEPSSIVQLDYSQKVL 185

  Fly   154 WNSYVRR-------RKWVRY-----RRYAALNSWCAVAPLHKDPTQEPFIDVAIGGTCVPNAPAG 206
            ..|.::|       .|.||.     |:.......|.:..|.|..      |:    |...:.|. 
Human   186 LVSTLQRSLLFYTEEKSVRQIGTQPRKSTGKFGACFIPGLCKQS------DL----TLYASRPG- 239

  Fly   207 TLCVWAITAHG--------RAMFRTGVSKTAPEGLRWTAVPTPTGSELAQISVGPTGLVWAVLHN 263
             |.:|....||        :..|..||.   |..|........:||  ..:.....|||......
Human   240 -LRLWKADVHGTVQATFILKDAFAGGVK---PFELHPRLESPNSGS--CSLPERHLGLVSCFFQE 298

  Fly   264 GRVIVRTGVTRDNLVGDSW-------LDVKTPVAASSLR----IVHVSVGTDAVWCVTNDHHAWF 317
            |.|:             ||       ||.......:.|.    ||.||       |..|:  .:|
Human   299 GWVL-------------SWNEYSIYLLDTVNQATVAGLEGSGDIVSVS-------CTENE--IFF 341

  Fly   318 RRG------VKGEAAGISEDSAIGKGWVEMVGNISMVSVAANDQVFAIGAADRCLYHRSGVTS-- 374
            .:|      :.....|::  |.:..| :||.|....|.|...:::.....::..|...|..:|  
Human   342 LKGDRNIIRISSRPEGLT--STVRDG-LEMSGCSERVHVQQAEKLPGATVSETRLRGSSMASSVA 403

  Fly   375 ADPTGKKWRLIQCPMQISRTSSSLSIVSRKSG----GSSSTP----GSK--HQSFSNLYS----- 424
            ::|..:              ||||:.....||    |..:||    ||:  .|.|:.:.|     
Human   404 SEPRSR--------------SSSLNSTDSGSGLLPPGLQATPELGKGSQPLSQRFNAISSEDFDQ 454

  Fly   425 ---------------KEKEKGVVETCAVIETVLNSSTGS--CSSNGGPPGLLKNERWKLSADSPP 472
                           |:.|.|...||       :||..|  ||...|              |||.
Human   455 ELVVKPIKVKRKKKKKKTEGGSRSTC-------HSSLESTPCSEFPG--------------DSPQ 498

  Fly   473 TIGSLNLNDRHKQRTAALRETSHASSAPAADVVEVVTGKFE---TQLRNPRAWSPVRSVGSVVGT 534
               ||| .|.....::.|..:....||.:.|......|:..   .:..:|..::.:...||:..:
Human   499 ---SLN-TDLLSMTSSVLGSSVDQLSAESPDQESSFNGEVNGVPQENTDPETFNVLEVSGSMPDS 559

  Fly   535 EAHPESDSTVFESDSTH--HGSDVFLGEDDDHTGSQFWTECGILWSCVASGAVTVDASNMPNW-- 595
            .|  |.|....|....|  ||.::..|..:|..||          .....|.....|.:.||.  
Human   560 LA--EEDDIRTEMPHCHHAHGRELLNGAREDVGGS----------DVTGLGDEPCPADDGPNSTQ 612

  Fly   596 --FNEQTSDSKVDVNANWRKDIVNKLQRRQEKLAKLQTVAKFEKAVELS-----SWVKSADARYQ 653
              |.||.|..    .|:..:||        :.:....|..:......|:     ||..||:    
Human   613 LPFQEQDSSP----GAHDGEDI--------QPIGPQSTFCEVPLLNSLTVPSSLSWAPSAE---- 661

  Fly   654 RPGGEFEDCIIELEWVSSGSGTDTNSSENSRSGD-------SGTFT-----VLSPDGAATKIQFP 706
                         :|:......:.:..|.|:..|       ||..:     .::.|....| :.|
Human   662 -------------QWLPGTRADEGSPVEPSQEQDILTSMEASGHLSTNLWHAVTDDDTGQK-EIP 712

  Fly   707 LSDITCVQCCSEAGAPRIAIHA----PHLPVNCSPVKLQFSSDSEMEDWLSHLSSVCSQINTMVG 767
            :|:    :.....|.....:.|    .|.|....|.:.|..:.|:.||..:|            |
Human   713 ISE----RVLGSVGGQLTPVSALAASTHKPWLEQPPRDQTLTSSDEEDIYAH------------G 761

  Fly   768 KPAGNAIWITSELGDVFVFDPANMKAHQTSEPSEGYVEKMDVSTCETPYYNTLYNGMPCGTELEI 832
            .|:.::....:|||                                           |..::.::
Human   762 LPSSSSETSVTELG-------------------------------------------PSCSQQDL 783

  Fly   833 SGCVYDDADQIRFDLQSHSAVKVQPHRVEKHRVIALHLNPRFNERTTVLNSMKESEWLDEIRNDK 897
            |....:||..::.|..:.|.:.              :..|.:...:.|::  ::..|..:.:...
Human   784 SRLGAEDAGLLKPDQFAESWMG--------------YSGPGYGILSLVVS--EKYIWCLDYKGGL 832

  Fly   898 MAFA-PGATFSLKIRALQD---HYLIIVNNAVYTDYKYRIDPESVTRLYVSGRIKLFNVLYRCPS 958
            ...| |||  .|:.:..:|   ...:..:.|:.    ::|:.:|             |..:.|..
Human   833 FCSALPGA--GLRWQKFEDAVQQVAVSPSGALL----WKIEQKS-------------NRAFACGK 878

  Fly   959 LIVSMERMHWRQMGGHIKRIFNSGVDVVWGISCDNTGWVYNGGWGGMFLK-GLEGSGKINPMIDT 1022
            :.:..:| ||          :.:....|:....|:|.|:.... |.::|: ||.........:..
Human   879 VTIKGKR-HW----------YEALPQAVFVALSDDTAWIIRTS-GDLYLQTGLSVDRPCARAVKV 931

  Fly  1023 HTYYVYENQRWNPISGFTAKSLPTDRHMWSDATGRQKRSKEHTKLLSTHC----EWISD------ 1077
            ...|        |:|..||:    :..:|:..   ::|:..:.:.:|:.|    :|..|      
Human   932 DCPY--------PLSQITAR----NNVVWALT---EQRALLYREGVSSFCPEGEQWKCDIVSERQ 981

  Fly  1078 ---------------WAIDY--NI----------PGGADKEGWQYAID----------FPANYHA 1105
                           ||:|.  |:          |.|.|...||.:|.          |....||
Human   982 ALEPVCITLGDQQTLWALDIHGNLWFRTGIISKKPQGDDDHWWQVSITDYVVFDQCSLFQTIIHA 1046

  Fly  1106 -H----------KKLTDCVRRRRWMK--RCR-----LSSSGPWQELSQSK--------------- 1137
             |          :|:.|.:|...|.:  :|:     :::||.|  :|..|               
Human  1047 THSVATAAQAPVEKVADKLRMAFWSQQLQCQPSLLGVNNSGVW--ISSGKNEFHVAKGSLIGTYW 1109

  Fly  1138 ----------------ILDAALQV-------LDEDVDHSCSGERNTAV----------------- 1162
                            :|.:|...       |.:.....||....:|.                 
Human  1110 NHVVPRGTASATKWAFVLASAAPTKEGSFLWLCQSSKDLCSVSAQSAQSRPSTVQLPPEAEMRAY 1174

  Fly  1163 -----AAWAIASNGDVLIRHGVCSLN---PRGDAWEHITSDQ----PLVGISVGPTGQVWTVARN 1215
                 |.||:.|.|.|.||    :|:   |.|..|..:...|    .|..::.| ...:|.....
Human  1175 AACQDALWALDSLGQVFIR----TLSKSCPTGMHWTRLDLSQLGAVKLTSLACG-NQHIWACDSR 1234

  Fly  1216 GMVFFRYGISRQNP--CGDAWQQVE---APAGVTFKAI--SVGRAGIWALDNQQRLAVRKEISRT 1273
            |.|:||.|....||  ...||..:|   .||||:..::  |.....:|.||::..:.||..|:..
Human  1235 GGVYFRVGTQPLNPSLMLPAWIMIEPPVQPAGVSLVSVHSSPNDQMLWVLDSRWNVHVRTGITEE 1299

  Fly  1274 FPEGSHWQFLPNAANVPPHTDQHCGFRSVSVGSEVWAISLNGIICRRCGITEENPAGVGW 1333
            .|.|:.|:.:|..        |.|.. ::|..: |||...||.:.||.|:|::||||..|
Human  1300 MPVGTAWEHVPGL--------QACQL-ALSTRT-VWARCPNGDLARRYGVTDKNPAGDYW 1349

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pex23NP_730508.1 DysFN 64..125 CDD:214777 6/30 (20%)
Hyd_WA 210..238 CDD:283993 8/35 (23%)
Hyd_WA 257..282 CDD:283993 3/24 (13%)
TECPR 280..320 CDD:214782 12/50 (24%)
TECPR 338..371 CDD:214782 6/32 (19%)
PH-like 639..759 CDD:302622 25/140 (18%)
Gal-bind_lectin 815..954 CDD:278752 19/142 (13%)
TECPR 966..1000 CDD:214782 6/33 (18%)
DysFN 1021..1081 CDD:214777 13/84 (15%)
DysFC 1092..>1113 CDD:128935 9/41 (22%)
Hyd_WA 1165..1192 CDD:283993 11/29 (38%)
Hyd_WA 1209..1237 CDD:283993 10/29 (34%)
Hyd_WA 1308..1333 CDD:283993 13/24 (54%)
TECPR2NP_055659.2 WD 1 23..66
WD40 36..365 CDD:225201 59/284 (21%)
WD40 repeat 37..73 CDD:293791
WD 2 67..114
WD40 repeat 79..121 CDD:293791
WD 3 115..161 9/37 (24%)
WD40 repeat 130..168 CDD:293791 9/40 (23%)
WD 4 162..203 9/42 (21%)
WD40 repeat 175..197 CDD:293791 5/21 (24%)
WD 5 204..265 13/72 (18%)
WD40 repeat 215..256 CDD:293791 10/52 (19%)
WD 6 266..309 11/60 (18%)
WD40 repeat 278..324 CDD:293791 11/60 (18%)
WD 7 310..343 10/41 (24%)
WD40 repeat 329..351 CDD:293791 8/30 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 379..439 15/73 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 463..542 23/103 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 579..637 15/79 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 758..779 7/75 (9%)
TECPR 1 945..976 5/33 (15%)
Hyd_WA 947..973 CDD:283993 4/28 (14%)
TECPR 2 994..1027 9/32 (28%)
Hyd_WA 996..1026 CDD:283993 8/29 (28%)
TECPR 3 1179..1209 12/33 (36%)
Hyd_WA 1181..1206 CDD:283993 10/28 (36%)
TECPR 4 1226..1259 10/32 (31%)
TECPR 5 1279..1310 9/30 (30%)
Hyd_WA 1281..1309 CDD:283993 9/27 (33%)
TECPR 6 1322..1353 14/29 (48%)
Hyd_WA 1324..1352 CDD:283993 14/26 (54%)
TECPR 1347..1379 CDD:214782 1/3 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1388..1411
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3669
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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