DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pex23 and Tecpr1

DIOPT Version :9

Sequence 1:	NP_730508.1	Gene:	Pex23 / 40229	FlyBaseID:	FBgn0052226	Length:	1350	Species:	Drosophila melanogaster
Sequence 2:	NP_081686.1	Gene:	Tecpr1 / 70381	MGIID:	1917631	Length:	1166	Species:	Mus musculus

Alignment Length:	1407	Identity:	444/1407 - (31%)
Similarity:	641/1407 - (45%)	Gaps:	327/1407 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPSFYLFAASSEGRVYTLSTNSGAWRELPYLGLEFKKICAVPNFLWAIGGDRQVYVHVHGLDVPI 65
            ||:..|:|....||||||||....|.....:.||||::.|.....|.|.||.|||::|...||||
Mouse     1 MPTSVLWAVDLFGRVYTLSTAGQYWELCKDVQLEFKRVSAATQCCWGIAGDNQVYLYVCSSDVPI 65

  Fly    66 RIREESYENERWLPIEGFSKTLLPTDRYRYSSADGSVERGVDKIRLPSMAWQWDGDWHLDLELDG 130
            |.|||:|||:||.|:.||.:.|||:||:.:|...|...|.:|.:.|||..|:|:.||::|....|
Mouse    66 RHREEAYENQRWNPMGGFCEKLLPSDRWPWSDVSGLQHRPLDGVALPSPHWEWESDWYVDENFGG 130

  Fly   131 QPLTEDGWMYALDFPATYSAKKSWNSYVRRRKWVRYRRYAALNSWCAVAPLHKDPTQ--EPFIDV 193
            :|..:.||.||:||||||:..|.|||.||||||:|||||.:.:||..: |...||.:  :||.|:
Mouse   131 EPTEKGGWTYAMDFPATYTRDKKWNSCVRRRKWIRYRRYKSRDSWAKI-PSKDDPKELPDPFNDL 194

  Fly   194 AIGGTCVPNAPAGTLCVWAITAHGRAMFRTGVSKTAPEGLRWTAVPTPTGSELAQISVGPTGLVW 258
            ::||..:...|.|.|.|||::..|:..:|..||...|||..|:.|.||  .|:.|||.||..|:|
Mouse   195 SVGGWEITEEPVGRLSVWAVSLQGKVWYREDVSHPNPEGSSWSLVETP--GEVVQISCGPHDLIW 257

  Fly   259 AVLHNGRVIVRTGVTRDNLVGDSWLDVKTPVAASSLRIVHVSVGTDAVWCVTNDHHAWFRRGVKG 323
            |.|..|:.:||.||.|:|..|..|..|:.|  .|...|:|||.|...||.:|.|...||||||
Mouse   258 ATLWEGQALVREGVCRNNPKGSYWSMVEPP--GSENGIMHVSAGVSVVWAITKDRKVWFRRGV-- 318

  Fly   324 EAAGISEDSAIGKGWVEMVGNISMVSVAANDQVFAIGAADRCLYHRSGVTSADPTGKKWRLIQCP 388
                 :..:..|..|:||||.::||:|..||||:.|...||.:|.|.|||.::.:||.|:.|...
Mouse   319 -----NSHNPCGTSWIEMVGEMTMVNVGLNDQVWGISCEDRAVYFRQGVTPSELSGKTWKAIVVG 378

  Fly   389 MQISR--TSSSLSIVSR--------KSGGSSSTPGSKHQSF-------------SNLYSKEKEKG 430
            .:..|  :.||.|::|.        :..|:.|.|.....|.             ..|.:....||
Mouse   379 RESDRSHSGSSSSLLSAGCFFGDEVRGSGTESAPSDTDASLEVERQGPEQPLPKEALDNSTNLKG 443

  Fly   431 VV----ETCAVIETVLNSSTGSCSSNG--GPPGLLKNERWKLSADSPPTIGSLNLNDRHKQRTAA 489
            .:    ||....:   :|:..:|.:.|  ..|...:::..:..|.:|..:...|::
Mouse   444 SLSKGHETSGNTD---HSTENACLTEGKEKAPETSRSDECRGPASTPAELPWTNID--------- 496

  Fly   490 LRETSHASSAPAADVVEVV----TGKFETQLRNPRAWSPVRSVGSVVGTEAHPESDSTVFESDST 550
            |:|....|:.|||...|..    .|.|...:..|            .|.:.||
Mouse   497 LKEPKKVSNQPAAGFPETAGLSSLGLFPMGMEEP------------YGADDHP------------ 537

  Fly   551 HHGSDVFLGEDDDHTGSQFWTECGILWSCVASGAVTVDASNMPNWFNEQTSDS------KVDV-- 607
                                     ||:.|:.||..|:|.:...||..|:..|      .:.:
Mouse   538 -------------------------LWAWVSGGACAVEAGSTLKWFTIQSGLSPSVQTLSLSITP 577

  Fly   608 --NANWRKDIVNKLQRRQEKLAKLQTVAKFEKAVELSSWVKSADARY---QRPGGEFEDCIIELE 667
              .|.|||.|..:|..|.::  :|::...:|:|||.|.|||:...::   .:| .::.|..:.||
Mouse   578 AQTAAWRKQIFQQLTERTKR--ELESFRHYEQAVEQSVWVKTGALQWWCDWKP-HKWVDVRVALE 639

  Fly   668 WVSSGSGTDTNSSENSRSGDSGTFTVLSPDGAATKIQFPLSDITCVQCCSEAGAPRIAIHAPHLP 732
            ..:...|          :.||..|...........:...|:::|.:...........|::.|...
Mouse   640 QFTGHDG----------ARDSILFIYYVVHEEKKYLHVFLNEVTVLVPVLNEAKHSFALYTPERT 694

  Fly   733 VNCSPVKLQFSSDSEMEDWLSHLSSVCSQINTMVGKPAGNAIWITSELGDVFVFDPANMKAHQTS 797
            ....||:|..:::.:|.|||:.||..|.:...:.|:|:..|||..:..||:||           |
Mouse   695 RQRWPVRLAAATEQDMNDWLALLSLSCCESRKVHGRPSPQAIWSVTCKGDIFV-----------S 748

  Fly   798 EPSEGYVEKMDVSTCETPYYNTLYNGMPCGTELEISGCVYDDADQIRFDLQSHSAVKVQPHRVEK 862
            |||.                                            ||::
Mouse   749 EPSP--------------------------------------------DLEA------------- 756

  Fly   863 HRVIALHLNPRFNERTTVLNSMKESEWLDEIRNDKMAFAPGATFSLKIRALQDHYLIIVNNAVYT 927
                        .||
Mouse   757 ------------RER-------------------------------------------------- 759

  Fly   928 DYKYRIDPESVTRLYVSGRIKLFNVLYRCPSLIVSMERMHWRQMGGHIKRIFNSGVDVVWGISCD 992
                                            ::..::|.|||||||::.|..:...|||||..|
Mouse   760 --------------------------------LLPCDQMFWRQMGGHLRIIEANSRGVVWGIGYD 792

  Fly   993 NTGWVYNGGWGGMFLKGLEGS-GKINPMIDTHTYYVYENQRWNPISGFTAKSLPTDRHMWSDATG 1056
            :|.|||.||:||...:||..| ..|....|..:.|:||||||||::|:|::.|||||.||||.||
Mouse   793 HTAWVYTGGYGGGCFQGLASSTSNIYTQSDVKSVYIYENQRWNPVTGYTSRGLPTDRFMWSDVTG 857

  Fly  1057 RQKRSKEHTKLLSTHCEWISDWAIDYNIPGGADKEGWQYAIDFPANYHAHKKLTDCVRRRRWMKR 1121
            .|:.:|..||..|....|:|||.:|:::|||.|:||||||.||||:||.:|.:.|.||||.|.::
Mouse   858 LQECTKAGTKPPSLQWTWVSDWYVDFSVPGGTDQEGWQYASDFPASYHGYKTMKDFVRRRCWARK 922

  Fly  1122 CRLSSSGPWQELSQSKILDAALQVLDEDVDHSCSGE-RNTAVAAWAIASNGDVLIRHGVCSLNPR 1185
            |:|.:||||.|::...:.|.::      :..|...: |...||.||::..||||.|.||..|||.
Mouse   923 CKLVTSGPWLEVAPITLSDVSI------IPESAHADGRGHNVALWAVSDKGDVLCRLGVSELNPA 981

  Fly  1186 GDAWEHITSDQPLVGISVGPTGQVWTVARNGMVFFRYGISRQNPCGDAWQQVEAPAGVTFKAISV 1250
            |.:|.|:.:|||...:|:|...|||.|||:|..|:|..:|...|.||.|..:.:|.......:||
Mouse   982 GSSWLHVGTDQPFASVSIGACYQVWAVARDGSAFYRGSVSPSQPAGDCWYHIPSPPKQKLTQVSV 1046

  Fly  1251 GRAGIWALDNQQRLAVRKEISRTFPEGSHWQFLPNAANVPPHTDQHCGFRSVSVG--SEVWAIS- 1312
            |:..::|||....|..|..|:.::|:||.|:.:.|  ||          |.||||  .:||.|:
Mouse  1047 GQTSVYALDENGNLWYRAGITPSYPQGSSWEHVSN--NV----------RKVSVGPLDQVWVIAN 1099

  Fly  1313 --------LNGIICRRCGITEENPAGVGWNLGIAGQWQNVSV 1346
                    ..|.:|||.|:....|.|.||:.||.|.|.::||
Mouse  1100 KVQGSHGLSRGTVCRRMGVQPREPKGQGWDYGIGGGWDHISV 1141

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pex23	NP_730508.1	DysFN	64..125	CDD:214777	30/60 (50%)
		Hyd_WA	210..238	CDD:283993	11/27 (41%)
		Hyd_WA	257..282	CDD:283993	11/24 (46%)
		TECPR	280..320	CDD:214782	16/39 (41%)
		TECPR	338..371	CDD:214782	17/32 (53%)
		PH-like	639..759	CDD:302622	27/122 (22%)
		Gal-bind_lectin	815..954	CDD:278752	4/138 (3%)
		TECPR	966..1000	CDD:214782	19/33 (58%)
		DysFN	1021..1081	CDD:214777	32/59 (54%)
		DysFC	1092..>1113	CDD:128935	13/20 (65%)
		Hyd_WA	1165..1192	CDD:283993	14/26 (54%)
		Hyd_WA	1209..1237	CDD:283993	13/27 (48%)
		Hyd_WA	1308..1333	CDD:283993	10/33 (30%)
Tecpr1	NP_081686.1	DysFN	64..125	CDD:214777	30/60 (50%)
		TECPR 1	209..240		12/30 (40%)
		Hyd_WA	211..239	CDD:283993	11/27 (41%)
		TECPR	234..270	CDD:214782	17/37 (46%)
		TECPR 2	254..285		13/30 (43%)
		TECPR 3	301..332		13/37 (35%)
		Hyd_WA	303..331	CDD:283993	12/34 (35%)
		TECPR	327..361	CDD:214782	17/33 (52%)
		TECPR 4	344..376		14/31 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	404..496		16/94 (17%)
		PH1_TECPR1	609..729	CDD:270112	28/130 (22%)
		PH	615..721	CDD:278594	23/116 (20%)
		TECPR 5	734..761		15/188 (8%)
		DysFN	821..882	CDD:214777	32/60 (53%)
		DysFC	893..926	CDD:128935	19/32 (59%)
		TECPR 6	958..989		17/30 (57%)
		Hyd_WA	960..988	CDD:283993	14/27 (52%)
		TECPR 7	1003..1034		14/30 (47%)
		Hyd_WA	1005..1033	CDD:283993	13/27 (48%)
		TECPR 8	1049..1080		10/30 (33%)
		Hyd_WA	1051..1079	CDD:283993	10/27 (37%)
		TECPR	1074..>1099	CDD:214782	13/36 (36%)
		TECPR 9	1092..1132		12/39 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850203
Domainoid	1	1.000	119	1.000	Domainoid score	I5812
eggNOG	1	0.900	-	-		E1_KOG3669
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9120
Inparanoid	1	1.050	750	1.000	Inparanoid score	I570
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49404
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003956
OrthoInspector	1	1.000	-	-		oto92458
orthoMCL	1	0.900	-	-		OOG6_107510
Panther	1	1.100	-	-	LDO	PTHR23250
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3891
SonicParanoid	1	1.000	-	-		X4982
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.790