DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pex23 and tecpr1a

DIOPT Version :9

Sequence 1:	NP_730508.1	Gene:	Pex23 / 40229	FlyBaseID:	FBgn0052226	Length:	1350	Species:	Drosophila melanogaster
Sequence 2:	XP_021335963.1	Gene:	tecpr1a / 556500	ZFINID:	ZDB-GENE-070112-1792	Length:	1205	Species:	Danio rerio

Alignment Length:	1402	Identity:	446/1402 - (31%)
Similarity:	655/1402 - (46%)	Gaps:	293/1402 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPSFYLFAASSEGRVYTLSTNSGAWRELPYLGLEFKKICAVPNFLWAIGGDRQVYVHVHGLDVPI 65
            |||..|:|....||||:|||....|.......||||:|.||....|:|..|..:|::||..||||
Zfish     1 MPSSLLWAVDVYGRVYSLSTAGQQWEHCREAHLEFKRITAVQQCCWSIACDHNIYLNVHASDVPI 65

  Fly    66 RIREESYENERWLPIEGFSKTLLPTDRYRYSSADGSVERGVDKIRLPSMAWQWDGDWHLDLELDG 130
            |.:|::|||:||.|::|||..|||:||:::|...|...:.:...:|||..|:|:|||::|....|
Zfish    66 RYQEDTYENQRWNPVDGFSDRLLPSDRWQWSDVTGLKHQPLADFQLPSENWEWEGDWYVDENFGG 130

  Fly   131 QPLTEDGWMYALDFPATYSAKKSWNSYVRRRKWVRYRRYAALNSWCAVAPLHKDPTQEPFIDVAI 195
            :|..:.||.||:||||||:..|.|||.||||:|:|||||.|.::|..:.........:||.|:..
Zfish   131 EPTEKGGWTYAIDFPATYTKDKKWNSCVRRRRWLRYRRYKAQDTWVKIPSDQTGSLPDPFNDITC 195

  Fly   196 GGTCVPNAPAGTLCVWAITAHGRAMFRTGVSKTAPEGLRWTAVPTPTGSELAQISVGPTGLVWAV 260
            ||..|...|.|.|.:||::..|:..||:|::...|||..|..|..|  .|:.|||.||..|||||
Zfish   196 GGWEVTEEPRGCLALWAVSLQGKVWFRSGINHHNPEGSFWEEVTVP--GEVVQISCGPGDLVWAV 258

  Fly   261 LHNGRVIVRTGVTRDNLVGDSWLDVKTP---VAASSLRIVHVSVGTDAVWCVTNDHHAWFRRGVK 322
            |..|.::||.|:.||.|.|.||:.|::|   |.|     |||:||.:.||.||.||..||||||
Zfish   259 LWEGHLLVREGIGRDCLRGSSWVTVESPNPGVGA-----VHVAVGVNVVWAVTKDHKVWFRRGV- 317

  Fly   323 GEAAGISEDSAIGKGWVEMVGNISMVSVAANDQVFAIGAADRCLYHRSGVTSADPTGKKWRLIQC 387
                  :..:..|..|:.|||.:.|::|..||||:.|...||.:|.|.|||:::.:||.|:::..
Zfish   318 ------NSHNPCGSSWISMVGEMVMINVGLNDQVWGIAFEDRAVYFRQGVTASELSGKAWKVVSL 376

  Fly   388 PMQISRTSSSLSIVSRKSGGSSSTPGSKHQSFSNLYS---KEKEKGVVETCAVIETVLNSSTGSC 449
            .....|:.||.|..|.:|.|.......:.||.:::.|   .|.:....|.....|.
Zfish   377 TRDNDRSHSSASASSLQSAGCFFGGEVRLQSQASMLSDADAETDPAAGEVVPAPEM--------- 432

  Fly   450 SSNGGPPGLLKNERWKLSADSPPTIGSLNLNDRHKQRTAALRETSHASSAPAADVVEVVTGKFET 514
               |..|   |....|:::||  .|..| ::||..|    :......|::|:....|....:.:.
Zfish   433 ---GDAP---KPRIPKVTSDS--FISEL-VSDREGQ----ISRRDVPSASPSIPEEEQPEKEVDD 484

  Fly   515 QLRNPRAWSPVRSVGSVVGTEAHPESDSTVFESDSTHHGSDVFLGEDDDHTGS------------ 567
            ::...:..||.:|.|      ..|:..:...|...||..|..  |.|...|.|
Zfish   485 RVSPAQVLSPSQSGG------VDPQWSNVDLEEAQTHLASGA--GGDAAETSSLSSVATYNLAVE 541

  Fly   568 -QFWTECGILWSCVASGAVTVDASNMPNWFNEQTS---DSKVDV---------NANWRKDIVNKL 619
             .:..:....|:.::.|...|:..:..||||..||   :|.:..         .|.|||.|..:|
Zfish   542 EPYGADEHPKWAWISGGGCLVECHSQLNWFNSSTSTTLNSSMQAMSFSITPAQTAAWRKQIFEQL 606

  Fly   620 QRRQEKLAKLQTVAKFEKAVE-------LSSWVKSADARYQR--PGGEFEDCIIELEWVSSGSGT 675
            ..|.::  :::....:|:|:|       .|.|||....::.|  ...::.|....||..|...|
Zfish   607 SERSKR--EMENFMHYEQAIEQTVIDNATSVWVKKGTMQWWRDWKPHKWVDVQFALEQFSGAEG- 668

  Fly   676 DTNSSENSRSGDSGTFTVLSPDGAATKIQFPLSDITCVQCCSEAGAPRIAIHAPHLPVNCSPVKL 740
                     :.|...|...:.:.....:...::::|.:...........||:.........|::|
Zfish   669 ---------NKDGILFIYYTFNDEKKYLHAFINEVTILVPVLNESKHTFAIYTAERTKQRWPIRL 724

  Fly   741 QFSSDSEMEDWLSHLSSVCSQINTMVGKPAGNAIWITSELGDVFVFDPANMKAHQTSEPSEGYVE 805
            ..:::.||.|||:.||..|.....:.|.|...|||..:..|||||           |||::
Zfish   725 AAATELEMYDWLALLSVSCCDSRGIQGPPCKQAIWSVTCKGDVFV-----------SEPTK---- 774

  Fly   806 KMDVSTCETPYYNTLYNGMPCGTELEISGCVYDDADQIRFDLQSHSAVKVQPHRVEKHRVIALHL 870
                                   |||.|
Zfish   775 -----------------------ELEAS------------------------------------- 779

  Fly   871 NPRFNERTTVLNSMKESEWLDEIRNDKMAFAPGATFSLKIRALQDHYLIIVNNAVYTDYKYRIDP 935
                                           |..|
Zfish   780 -------------------------------PYPT------------------------------ 783

  Fly   936 ESVTRLYVSGRIKLFNVLYRCPSLIVSMERMHWRQMGGHIKRIFNSGVDVVWGISCDNTGWVYNG 1000
                                      :.::|.|||:|||::.:.::.:.|||||..|:|.||:.|
Zfish   784 --------------------------ACDQMFWRQVGGHLRIVESNSLGVVWGIGYDHTAWVHTG 822

  Fly  1001 GWGGMFLKGLEGS-GKINPMIDTHTYYVYENQRWNPISGFTAKSLPTDRHMWSDATGRQKRSKEH 1064
            |:||.|.:||..| ..|....|..:.|:||||||||::|:|.:.|||||:|||||:|.::.:|.:
Zfish   823 GYGGGFFQGLASSTDNIYTQTDVKSVYIYENQRWNPVTGYTDRGLPTDRYMWSDASGLKECTKNN 887

  Fly  1065 TKLLSTHCEWISDWAIDYNIPGGADKEGWQYAIDFPANYHAHKKLTDCVRRRRWMKRCRLSSSGP 1129
            ||..|.|..|:|:|:|||::.||.|:||||||.||||:||.:|.|.|.||||||.::|:|:::||
Zfish   888 TKPPSPHWTWVSEWSIDYSVAGGTDREGWQYAADFPASYHGYKTLKDFVRRRRWARKCKLTTTGP 952

  Fly  1130 WQELSQSKILDAALQVLDEDVDHSCSGERNTA--VAAWAIASNGDVLIRHGVCSLNPRGDAWEHI 1192
            |||:....:.|..:.        .| |.::|.  |:.|||::.||||.|.||.||.|.|.:|.|:
Zfish   953 WQEVPPIPLSDITIL--------PC-GPKSTVEQVSLWAISNKGDVLCRLGVTSLTPGGSSWLHV 1008

  Fly  1193 TSDQPLVGISVGPTGQVWTVARNGMVFFRYGISRQNPCGDAWQQVEAPAGVTFKAISVGRAGIWA 1257
            .:|||...||:|...|||.:|::|..|:|..:|.|.|.||.|..:.:|.|...|.:||||..::.
Zfish  1009 GTDQPFKSISIGGVHQVWAIAKDGSAFYRGSVSTQTPAGDCWYHIPSPTGQKLKQVSVGRTSVYT 1073

  Fly  1258 LDNQQRLAVRKEISRTFPEGSHWQFLPNAANVPPHTDQHCGFRSVSVG--SEVWAI--------S 1312
            :|....|..|..:..::|:||.|:.:.|  ||          |.||||  .:||.|        |
Zfish  1074 VDENGNLWYRHGVMPSYPQGSSWEHISN--NV----------RKVSVGPLDQVWIIADKVQGSHS 1126

  Fly  1313 LN-GIICRRCGITEENPAGVGWNLGIAGQWQNVSVEG 1348
            |: |.:|||.|:....|.|..|:.||.|.|.:::|.|
Zfish  1127 LSCGTVCRRLGVLPMEPKGHSWDYGIGGGWDHITVRG 1163

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pex23	NP_730508.1	DysFN	64..125	CDD:214777	28/60 (47%)
		Hyd_WA	210..238	CDD:283993	10/27 (37%)
		Hyd_WA	257..282	CDD:283993	13/24 (54%)
		TECPR	280..320	CDD:214782	20/42 (48%)
		TECPR	338..371	CDD:214782	15/32 (47%)
		PH-like	639..759	CDD:302622	25/128 (20%)
		Gal-bind_lectin	815..954	CDD:278752	6/138 (4%)
		TECPR	966..1000	CDD:214782	16/33 (48%)
		DysFN	1021..1081	CDD:214777	31/59 (53%)
		DysFC	1092..>1113	CDD:128935	14/20 (70%)
		Hyd_WA	1165..1192	CDD:283993	15/26 (58%)
		Hyd_WA	1209..1237	CDD:283993	12/27 (44%)
		Hyd_WA	1308..1333	CDD:283993	12/33 (36%)
tecpr1a	XP_021335963.1	DysFN	64..125	CDD:214777	28/60 (47%)
		Hyd_WA	210..238	CDD:310810	10/27 (37%)
		TECPR	233..269	CDD:214782	18/37 (49%)
		Hyd_WA	303..330	CDD:310810	13/33 (39%)
		TECPR	325..360	CDD:214782	15/34 (44%)
		PH-like	634..751	CDD:327399	25/126 (20%)
		DysFN	843..904	CDD:214777	31/60 (52%)
		DysFC	915..948	CDD:128935	21/32 (66%)
		Hyd_WA	980..1008	CDD:310810	15/27 (56%)
		Hyd_WA	1025..1053	CDD:310810	12/27 (44%)
		Hyd_WA	1071..1099	CDD:310810	7/27 (26%)
		TECPR	1094..>1117	CDD:214782	12/34 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	119	1.000	Domainoid score	I5763
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H9120
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D119234at2759
OrthoFinder	1	1.000	-	-		FOG0003956
OrthoInspector	1	1.000	-	-		otm26290
orthoMCL	1	0.900	-	-		OOG6_107510
Panther	1	1.100	-	-	LDO	PTHR23250
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3891
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.950