DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pex23 and tecpr1

DIOPT Version :9

Sequence 1:	NP_730508.1	Gene:	Pex23 / 40229	FlyBaseID:	FBgn0052226	Length:	1350	Species:	Drosophila melanogaster
Sequence 2:	NP_001107288.1	Gene:	tecpr1 / 100135077	XenbaseID:	XB-GENE-5865975	Length:	1173	Species:	Xenopus tropicalis

Alignment Length:	1376	Identity:	446/1376 - (32%)
Similarity:	665/1376 - (48%)	Gaps:	267/1376 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPSFYLFAASSEGRVYTLSTNSGAWRELPYLGLEFKKICAVPNFLWAIGGDRQVYVHVHGLDVPI 65
            |||..|:|....|:|:||||:...|.......:|||::.||.:..|.:|.:.|:|::||..|:||
Frog     1 MPSTVLWATDIFGKVFTLSTDGQQWAPCKNGHVEFKRVSAVRSCCWGVGCNHQIYLYVHASDLPI 65

  Fly    66 RIREESYENERWLPIEGFSKTLLPTDRYRYSSADGSVERGVDKIRLPSMAWQWDGDWHLDLELDG 130
            |.:||:|||:||.|::|:.:.|||:||:::|...|...:.::...|||..|:|:.||::|..:.|
Frog    66 RYQEETYENQRWNPVDGYCEKLLPSDRWQWSDVTGLRHQQLESFMLPSPHWEWESDWYVDENIGG 130

  Fly   131 QPLTEDGWMYALDFPATYSAKKSWNSYVRRRKWVRYRRYAALNSWCAVAPLHKDPTQ--EPFIDV 193
            :|..:.||.||:||||||:..|.|||.||||:|:|||:|.:.|:|..: |.|:|..:  :||.|:
Frog   131 EPTEKGGWTYAIDFPATYTKDKKWNSCVRRRRWIRYRKYKSRNTWAKI-PSHEDNKKLPDPFNDI 194

  Fly   194 AIGGTCVPNAPAGTLCVWAITAHGRAMFRTGVSKTAPEGLRWTAVPTPTGSELAQISVGPTGLVW 258
            .:||..:.:.|.|.|.|||.:..|:..:|..|.:..|||..||.:.||  ||:.|||.||..|:|
Frog   195 TVGGWEITDEPVGRLSVWAASLQGKVWYREDVCQNIPEGSSWTELETP--SEVIQISCGPNDLLW 257

  Fly   259 AVLHNGRVIVRTGVTRDNLVGDSWLDVKTPVAASSLRIVHVSVGTDAVWCVTNDHHAWFRRGVKG 323
            |.|..|:.:||.|:.|:|..|.||..|:.|...:.  |:|||||.:.||.||.|...||||||
Frog   258 ASLWEGQAMVREGINRNNPKGSSWTIVEAPTPENG--IMHVSVGVNVVWAVTKDRKVWFRRGV-- 318

  Fly   324 EAAGISEDSAIGKGWVEMVGNISMVSVAANDQVFAIGAADRCLYHRSGVTSADPTGKKWRLIQCP 388
                 :..:..|.||:||||.::||.|..|||||.:|..||.:|.|.|||.::.:||.|:.|..|
Frog   319 -----NSHNPCGTGWIEMVGEMAMVDVGLNDQVFGVGYEDRAVYFRQGVTPSELSGKAWKSIVVP 378

  Fly   389 MQISRTSSSLSIVSRKSGGSSSTPGSKHQSFSNLYSKEKEKGVVETCAVIETVLNSSTGSCSSNG 453
            ....| |:|.|..|..|.|.......|..|.|.:.|..:.....|..||.|   |||..|..::.
Frog   379 RGNER-SNSESPNSLLSAGCFFGDEIKEHSDSPIPSDIESSSEPEQSAVQE---NSSDSSEPADV 439

  Fly   454 GPPGLLKNERWKLSADSPPTIGSLNLNDRHKQRTAALRETSHASSAPAADVVEVVTGKFET-QLR 517
            ||....:.:..:|||       .|.|:.:.|..::..:::...|:..|..|.:....|:.: .|.
Frog   440 GPSQQDEPKDEELSA-------VLELDGQQKAGSSLSKDSGEDSAHSAGPVPKAGAPKWTSIDLL 497

  Fly   518 NPRAWSPVRSVGSVVGTEAHPESDSTVFESDSTHHGSDVFLGEDDDHTGSQFWTECGILWSCVAS 582
            ..|. :|.|:.|.:.|.     |...:|.:           ||::     .|..|...||:.|:.
Frog   498 EARI-NPARASGDMTGL-----STLGIFTA-----------GEEE-----SFVCETHPLWTWVSG 540

  Fly   583 GAVTVDASNMPNWFNEQT--SDSKVDVN--------ANWRKDIVNKLQRRQEKLAKLQTVAKFEK 637
            |...|::.....||..||  |.|...::        |.|||.|.::|..|.::  :|.:...:|:
Frog   541 GGCLVESHTPLKWFTLQTGLSASMQSLSLSITPAHTAAWRKQIFDQLSERSKR--ELDSFRHYEQ 603

  Fly   638 AVELSSWVKSADARYQR--PGGEFEDCIIELEWVSSGSGTDTNSSENSRSGDSGTFTVLSPDGAA 700
            |||.|.|||:...::.|  ...::.|..:.||.:   :|||       .|.||..|...:.....
Frog   604 AVEQSVWVKTGALQWYRDWKPNKWIDVRVALEQL---TGTD-------GSRDSILFVYYTHGEEK 658

  Fly   701 TKIQFPLSDITCVQCCSEAGAPRIAIHAPHLPVNCSPVKLQFSSDSEMEDWLSHLSSVCSQINTM 765
            ..|...|:::|.:...:.......||:.|.......|::|..:::.||.|||..||..|.:...:
Frog   659 KYIHIFLNEVTILVPVANEAKHSFAIYTPEKTKQRWPIRLAAATEQEMHDWLVLLSMSCYESRKL 723

  Fly   766 VGKPAGNAIWITSELGDVFVFDPANMKAHQTSEPSEGYVEKMDVSTCETPYYNTLYNGMPCGTEL 830
            .|.|:..|||..:..||:||.:|                 |.|:        .:|.||..|
Frog   724 QGAPSSQAIWSVTCKGDIFVSEP-----------------KADL--------ESLSNGRSC---- 759

  Fly   831 EISGCVYDDADQIRFDLQSHSAVKVQPHRVEKHRVIALHLNPRFNERTTVLNSMKESEWLDEIRN 895

Frog   760 ----------------------------------------------------------------- 759

  Fly   896 DKMAFAPGATFSLKIRALQDHYLIIVNNAVYTDYKYRIDPESVTRLYVSGRIKLFNVLYRCPSLI 960

Frog   760 ----------------------------------------------------------------- 759

  Fly   961 VSMERMHWRQMGGHIKRIFNSGVDVVWGISCDNTGWVYNGGWGGMFLKGLEGS-GKINPMIDTHT 1024
               ::|.|||:|||::.:.:|...||||:..|:|.|||.||:||.|..|:..| ..|.|..||..
Frog   760 ---DQMFWRQIGGHLRMVESSSNGVVWGLGYDHTAWVYTGGYGGGFFPGIASSTDNIFPQTDTKC 821

  Fly  1025 YYVYENQRWNPISGFTAKSLPTDRHMWSDATGRQKRSKEHTKLLSTHCEWISDWAIDYNIPGGAD 1089
            .|:|||||||||:|:::..|||||:|||||:|.|:.:|.:||..|....|:|||.||:|:|||.|
Frog   822 VYIYENQRWNPITGYSSTGLPTDRYMWSDASGLQECTKTNTKPPSPQWTWVSDWYIDFNVPGGTD 886

  Fly  1090 KEGWQYAIDFPANYHAHKKLTDCVRRRRWMKRCRLSSSGPWQELSQSKILDAALQVLDEDVDHSC 1154
            :||||:|.||||:||.:|.:.|.||||||.::||:.:||||.|:....:.|.::.        ..
Frog   887 REGWQFAADFPASYHGYKTIKDFVRRRRWARKCRIVTSGPWLEVPPICLWDISIS--------PS 943

  Fly  1155 SGERNT-AVAAWAIASNGDVLIRHGVCSLNPRGDAWEHITSDQPLVGISVGPTGQVWTVARNGMV 1218
            ||..|: ::|.|||::.||||.|.||...:|.|.:|.|:.:|||.:.:|||...|||.:||:|..
Frog   944 SGAHNSESIALWAISNKGDVLCRLGVTKQSPSGSSWLHVGTDQPFISVSVGGCLQVWAIARDGSA 1008

  Fly  1219 FFRYGISRQNPCGDAWQQVEAPAGVTFKAISVGRAGIWALDNQQRLAVRKEISRTFPEGSHWQFL 1283
            |:|..:|...|.||.|..:.:|.....:.:|||...::.:|....|..|..|:.|:|:|:.|:.:
Frog  1009 FYRGSVSPAQPAGDCWYHIPSPHKQKLQQVSVGHTSVFVVDENGNLWFRHGITPTYPQGTTWEHM 1073

  Fly  1284 PNAANVPPHTDQHCGFRSVSVG--SEVWAI--------SLN-GIICRRCGITEENPAGVGWNLGI 1337
            .|            ..|.||||  .::|.|        ||: |.:|.|.|:......|..|:.||
Frog  1074 SN------------NIRKVSVGPLDQIWVIADKVQGSHSLSCGTVCHRLGVQPMQLKGHSWDYGI 1126

  Fly  1338 AGQWQNVSVEG 1348
            .|.|::::|.|
Frog  1127 GGGWEHITVRG 1137

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pex23	NP_730508.1	DysFN	64..125	CDD:214777	26/60 (43%)
		Hyd_WA	210..238	CDD:283993	11/27 (41%)
		Hyd_WA	257..282	CDD:283993	10/24 (42%)
		TECPR	280..320	CDD:214782	18/39 (46%)
		TECPR	338..371	CDD:214782	18/32 (56%)
		PH-like	639..759	CDD:302622	32/121 (26%)
		Gal-bind_lectin	815..954	CDD:278752	4/138 (3%)
		TECPR	966..1000	CDD:214782	17/33 (52%)
		DysFN	1021..1081	CDD:214777	33/59 (56%)
		DysFC	1092..>1113	CDD:128935	12/20 (60%)
		Hyd_WA	1165..1192	CDD:283993	13/26 (50%)
		Hyd_WA	1209..1237	CDD:283993	12/27 (44%)
		Hyd_WA	1308..1333	CDD:283993	9/33 (27%)
tecpr1	NP_001107288.1	DysFN	64..125	CDD:214777	26/60 (43%)
		TECPR 1	209..240		12/30 (40%)
		Hyd_WA	211..239	CDD:283993	11/27 (41%)
		TECPR 2	254..285		13/30 (43%)
		Hyd_WA	256..284	CDD:283993	12/27 (44%)
		TECPR 3	301..332		15/37 (41%)
		Hyd_WA	303..331	CDD:283993	14/34 (41%)
		TECPR 4	344..376		15/31 (48%)
		Hyd_WA	346..375	CDD:283993	13/28 (46%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	403..489		23/95 (24%)
		PH1_TECPR1	605..725	CDD:270112	33/129 (26%)
		PH	611..718	CDD:278594	28/116 (24%)
		TECPR 5	730..757		12/51 (24%)
		TECPR	762..795	CDD:214782	16/32 (50%)
		DysFN	817..878	CDD:214777	33/60 (55%)
		TECPR 6	952..983		15/30 (50%)
		Hyd_WA	954..982	CDD:283993	13/27 (48%)
		TECPR 7	997..1028		13/30 (43%)
		Hyd_WA	999..1027	CDD:283993	12/27 (44%)
		TECPR 8	1043..1074		8/30 (27%)
		Hyd_WA	1045..1073	CDD:283993	8/27 (30%)
		TECPR 9	1086..1126		10/39 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1147..1173
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	117	1.000	Domainoid score	I5837
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9120
Inparanoid	1	1.050	780	1.000	Inparanoid score	I518
OMA	1	1.010	-	-		QHG49404
OrthoDB	1	1.010	-	-		D119234at2759
OrthoFinder	1	1.000	-	-		FOG0003956
OrthoInspector	1	1.000	-	-		otm47814
Panther	1	1.100	-	-	LDO	PTHR23250
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3891
SonicParanoid	1	1.000	-	-		X4982
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110