DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17122 and cfap157

DIOPT Version :9

Sequence 1:	NP_730506.1	Gene:	CG17122 / 40226	FlyBaseID:	FBgn0036962	Length:	598	Species:	Drosophila melanogaster
Sequence 2:	NP_001103638.1	Gene:	cfap157 / 794225	ZFINID:	ZDB-GENE-060526-118	Length:	471	Species:	Danio rerio

Alignment Length:	483	Identity:	119/483 - (24%)
Similarity:	238/483 - (49%)	Gaps:	65/483 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPPKV--KK--------------EKKDVNKVTQVDRTFYELTITDLNQKLARLRSHVTTVDESNI 49
            ||||.  ||              |:|:..::|:.|:.||:..|.||.::|.|.:.....::....
Zfish     1 MPPKKNGKKNRDQAIKTGGMEETEQKNAEELTESDKKFYQAQIRDLEERLERYQLKCDELEVQEK 65

  Fly    50 TLTEKLKEVEADGVDVAAHLERTLAERNNSITELEERLVEITKVRDVENRVAQEKIGDLESKYKA 114
            .|:.|:..||.:..|:...|:||||::.:.:.:|.|.|....:.::.|....:.::..|..:.:.
Zfish    66 DLSSKINNVEKEKKDIVLFLKRTLAKKEDKLNDLAETLSRHQQAQEAERESFESQLSLLRRELQE 130

  Fly   115 MHDQLTSEIKLLNGKLNSLDEFRIQRDVLLAKFDEQEADLNEREKDHKEALYNMEQRAVVEKDAL 179
            ..::.|||...|.|||.||:||..||:.|:|:....|..|.::::||:..:||:|::||::.|.|
Zfish   131 NKEKYTSENMTLAGKLASLEEFSTQRETLIAERRSLEEQLRKQKEDHQAEIYNLEKKAVLDNDRL 195

  Fly   180 KKEVEQKLLQVSEDFTRSSEIRNAGYTRRLIRENIALQKEIDLLVMSQIKLQQAYTNQKSKHKEM 244
            |||:.|.:..|:.:|.|.|:.:....|.|.::||:::..::..|.....:|.:.....:::.:::
Zfish   196 KKEMLQHVATVAAEFRRVSDEKMPETTLRAMQENLSVTAQLQQLSEKTKELLKENDALRARERQL 260

  Fly   245 EEQYSALDQIKNELVRNSVNKIKIIEGLTRNYEKLKAKYVEVLRYKKAYESLLQ-----AEKCEN 304
            :.:....:.:.:|:.:.||...|::..||...::::::..:..:.|:.::.||.     ..:.|:
Zfish   261 KRENGITEPLLHEITKKSVANQKVVLQLTEKCKQMQSEVEKCTKLKQDHQELLDIHSAVCTEIED 325

  Fly   305 VKQKDAAGKLRTLAKRMEILDLDNRNLEVVHAQHEI-EITRLRGVIQEIKCTVRDAIVAEQAAKK 368
            :::|.||          ...||:....||...:.|: |.:|:|..|.         .|.|:||..
Zfish   326 LRKKHAA----------VTEDLNQTKAEVERQKKELEEESRMRAQIN---------TVLEEAAVA 371

  Fly   369 FPERLVEANVDDPAMINEVREEAISLCK--LKRSDLLSQLMSIVSSHSEELPKTPSIASIVSA-- 429
            ..|.|           .:|.||..|..|  ::||.::.:|::::.. :..|.|.|::..:::.
Zfish   372 LKEAL-----------RDVPEEEDSELKVTVRRSQMMQKLLAVLDG-AAALGKGPALTDLMTCRP 424

  Fly   430 -----TS---SLYAPGKMGFMPTRPKAT 449
                 ||   |.|..|.:|.:|.:..:|
Zfish   425 GALQKTSPHLSHYKTGDLGLVPRKTHST 452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17122	NP_730506.1	Smc	<24..267	CDD:224117	63/242 (26%)
CG17122	NP_730506.1	Smc	<169..>406	CDD:224117	54/244 (22%)
cfap157	NP_001103638.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..33		8/31 (26%)
		Orbi_VP5	58..>219	CDD:279272	49/160 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	447..471		1/6 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596011
Domainoid	1	1.000	155	1.000	Domainoid score	I4206
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	155	1.000	Inparanoid score	I4282
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1171749at2759
OrthoFinder	1	1.000	-	-		FOG0007440
OrthoInspector	1	1.000	-	-		oto40940
orthoMCL	1	0.900	-	-		OOG6_105876
Panther	1	1.100	-	-	LDO	PTHR31954
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5700
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.930