DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17122 and cfap157

DIOPT Version :9

Sequence 1:	NP_730506.1	Gene:	CG17122 / 40226	FlyBaseID:	FBgn0036962	Length:	598	Species:	Drosophila melanogaster
Sequence 2:	XP_012816863.1	Gene:	cfap157 / 780234	XenbaseID:	XB-GENE-5795998	Length:	520	Species:	Xenopus tropicalis

Alignment Length:	574	Identity:	147/574 - (25%)
Similarity:	274/574 - (47%)	Gaps:	96/574 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPPKVK---------KEKKDV----NKVTQVDRTFYELTITDLNQKLARLRSHVTTVDESNITLT 52
            ||||.|         |||:.|    ..||:..:.||.:.|.||.::|.|.:|   ..||  |...
Frog     1 MPPKKKGKRGPSAKTKEKETVRVASEGVTEQTKDFYTVQIRDLEKRLERYQS---KWDE--ICAK 60

  Fly    53 EKLKEVE-----ADGVDVAAHLERTLAERNNSITELEERLVEITKVRDVENRVAQEKIGDLESKY 112
            |:|||.:     .|..::.:.|:|||.:|.:.|.:|.::|:.:.:.:|.|....:.::..:..:.
Frog    61 EQLKEAQYEQLSNDKKEIVSFLKRTLNQRMDEIADLNDQLLGLQQAKDAEKDAYESQLTQVRHEL 125

  Fly   113 KAMHDQLTSEIKLLNGKLNSLDEFRIQRDVLLAKFDEQEADLNEREKDHKEALYNMEQRAVVEKD 177
            :...::||||..||.|||.||:|||:|::.|:.||...|..:.|:|::||||:|.:|::.|::||
Frog   126 QDTKERLTSENMLLAGKLASLEEFRVQKEELMGKFAALEEKVKEQEQEHKEAMYILEKKVVLDKD 190

  Fly   178 ALKKEVEQKLLQVSEDFTRSSEIRNAGYTRRLIRENIALQKEIDLLVMSQIKLQQAYTNQKSKHK 242
            .||||:.|::..|:.:|.|.|..:.|..|:|.||||:::..::|.:....|:|.......|.::.
Frog   191 RLKKEMVQRVSTVAAEFRRVSNNQMAETTKRAIRENVSISLQLDKMSDKSIELISENDLLKDRNS 255

  Fly   243 EMEEQYSALDQIKNELVRNSVNKIKIIEGLTRNYEKLKAKYVEVLRYKKAYESLLQAEKCENVKQ 307
            |:.:|...|::.:.|||:|:::..|:|..||...::.:    |:|...:..:..|...:.::...
Frog   256 ELTKQLEMLEENEKELVKNNLSNQKVIRMLTDKCQQQQ----EILTLLEHTQHALNELQSQHHNL 316

  Fly   308 KDAAGKLRTLAKRMEILDLDNRNLEVVHAQHEIEITRLRGVIQEIKCTVRDAIVAEQAAKKFPER 372
            ||.:.:|     :.:::.|::....|...:..:.    |.:.:|.:.|:...::..|||....:.
Frog   317 KDESQQL-----KQKLVSLEDDLQRVTQEKEGLS----RQLEEEKQRTLAVDMILSQAAAFLKDM 372

  Fly   373 LVEANVDDPAMINEVREEAISLCKLKRSDLLSQLMSIVSS----------HSEELPKTPSIASIV 427
            |::.:.:|       ..|.:.|  .:|:.:|.||..::.|          |..|..:..|:.|:.
Frog   373 LLQTHSED-------ETEGMQL--ERRNKMLQQLQLLLDSSATLGLGSSLHEFETKQGHSLKSLK 428

  Fly   428 S------------ATSSLYAPGKMGFMPTRPKATPFDAFRSEVIEQEPDRTVPEDLQKQKMQDRL 480
            :            ..::.|..|.:|.:|                .|:....|   |.|..|..::
Frog   429 TNRQPVSPVLKGPGVTAHYRIGDLGLVP----------------RQDVSNAV---LSKTAMLSKI 474

  Fly   481 --MTSLRGDENTIIDVEFGTTLYVSSSREDDLIEVEEEPLEEPEGSTSSMSVKK 532
              :..|||...  |..|.     :|.::|:..|:....|...| |:.|.:.:.|
Frog   475 TRLGPLRGTHG--ISKEL-----LSWTQEEKQIKHSALPEISP-GAPSKLLMAK 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17122	NP_730506.1	Smc	<24..267	CDD:224117	81/247 (33%)
CG17122	NP_730506.1	Smc	<169..>406	CDD:224117	55/236 (23%)
cfap157	XP_012816863.1	SMC_prok_B	40..>368	CDD:274008	99/345 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	161	1.000	Domainoid score	I3979
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I4124
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1171749at2759
OrthoFinder	1	1.000	-	-		FOG0007440
OrthoInspector	1	1.000	-	-		otm47779
Panther	1	1.100	-	-	LDO	PTHR31954
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5700
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.100