DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17122 and Cfap157

DIOPT Version :9

Sequence 1:	NP_730506.1	Gene:	CG17122 / 40226	FlyBaseID:	FBgn0036962	Length:	598	Species:	Drosophila melanogaster
Sequence 2:	NP_001094339.1	Gene:	Cfap157 / 499781	RGDID:	1560002	Length:	542	Species:	Rattus norvegicus

Alignment Length:	512	Identity:	123/512 - (24%)
Similarity:	229/512 - (44%)	Gaps:	106/512 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPPKVKKEK--------------KDVN-----KVTQVD--RTFYELTITDLNQKLARLRSHVTTV 44
            |.||.|..|              ||.:     ::..|:  :.||...|.||..:|||   :....
  Rat     1 MAPKKKSNKGGKEIQSKKKIGGRKDTSGSKTPELAMVEELKEFYHKQIQDLEDRLAR---YQRKW 62

  Fly    45 DESNITLTEKLKEVEADGV-----DVAAHLERTLAERNNSITELEERLVEITKVRDVENRVAQEK 104
            ||  :.:.|||...|.:.:     ::.|.|:|||.:|.:.||:|.::|..:...:::|....:.:
  Rat    63 DE--LAVQEKLFRQEFEQLANNKKEIVAFLKRTLNQRVDEITDLNDQLQSLQVAKEMEKDAFEAQ 125

  Fly   105 IGDLESKYKAMHDQLTSEIKLLNGKLNSLDEFRIQRDVLLAKFDEQEADLNEREKDHKEALYNME 169
            :..:..:::...||||:|...|..||:||:|||:|::.|..|:...|..|..:|.::|:.:||:|
  Rat   126 LAQVRHEFQETKDQLTTENIALGIKLSSLEEFRLQKEELTEKYMALEEQLRRQEGEYKDYVYNLE 190

  Fly   170 QRAVVEKDALKKEVEQKLLQVSEDFTRSSEIRNAGYTRRLIRENIALQKEIDLLVMSQIKLQQAY 234
            :::|::||.|:||:.|::..|:.:|.:.:..:....|||.|.||..:..::..:....::|.|..
  Rat   191 KKSVLDKDRLRKEIIQRVNLVATEFRKVATNQMWETTRRAILENNNVTLQLSKVSKQGVQLLQEN 255

  Fly   235 TNQKSKHKEMEEQYSALDQIKNELVRNSVNKIKIIEGLTR--NYEKLKAKYVEVLRYKKAYESLL 297
            ...|....::.:|...|:..:..:.:.::...|:|..||.  ..::...:..|.||.:     |.
  Rat   256 EQLKGAQGKLCQQLELLENTQEIMAKKNIGNQKVILMLTEKCRQQRKGTEEAEQLRLQ-----LF 315

  Fly   298 QAEKCENVKQKDAAGKLRTLAKRMEILD--LDNRNLEVVHAQHEIE-----ITRLRGVIQEIKCT 355
            |.|  :|::..:.|.  :||....:.||  |..:..|....|.|:.     .|.|:.|:.:....
  Rat   316 QLE--QNIETLEKAN--QTLRSEKDQLDEQLKEQRAEANRLQEELTKEQKIRTNLKTVLTQATSL 376

  Fly   356 VRDAIVAEQAAKKFPERLVEANVDDPAMINEVREEAIS-----LCKLKRSDLLSQLMSIVS---- 411
            :||                         |.::|.|...     :.:|:|.:||.||:.::|
  Rat   377 LRD-------------------------ILQMRPETEDGDFDVVFQLQRKELLQQLLVLLSSAVV 416

  Fly   412 --------SHSEELP-------------KTPSIASIVSATSSL--YAPGKMGFMPTR 445
                    ||.::.|             .....||::...|::  |.||.:|.:|.|
  Rat   417 SKPQQDMGSHQDKQPAGLSKDSRLIAQTSKQGAASLLQQLSTITTYQPGDLGLVPRR 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17122	NP_730506.1	Smc	<24..267	CDD:224117	66/247 (27%)
CG17122	NP_730506.1	Smc	<169..>406	CDD:224117	53/250 (21%)
Cfap157	NP_001094339.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..32		7/30 (23%)
Cfap157	NP_001094339.1	SMC_prok_B	51..>361	CDD:274008	84/323 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353842
Domainoid	1	1.000	123	1.000	Domainoid score	I5436
eggNOG	1	0.900	-	-		E1_28I9U
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	124	1.000	Inparanoid score	I4628
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1171749at2759
OrthoFinder	1	1.000	-	-		FOG0007440
OrthoInspector	1	1.000	-	-		oto95971
orthoMCL	1	0.900	-	-		OOG6_105876
Panther	1	1.100	-	-	LDO	PTHR31954
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.760