DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gogo and THSD1

DIOPT Version :9

Sequence 1:	NP_649200.2	Gene:	gogo / 40225	FlyBaseID:	FBgn0052227	Length:	1272	Species:	Drosophila melanogaster
Sequence 2:	NP_061146.1	Gene:	THSD1 / 55901	HGNCID:	17754	Length:	852	Species:	Homo sapiens

Alignment Length:	990	Identity:	194/990 - (19%)
Similarity:	300/990 - (30%)	Gaps:	314/990 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 SSIMLLLLSGTSHVLAVRKGRLMSPSTFTALSGD-LHVQIQFNGNEMSSQAEEEHTIGGGPSNEE 99
            |:::|::|  ..:||...:..|:......|||.| ::|..|:
Human     9 SNLLLVVL--CDYVLGEAEYLLLREPGHVALSNDTVYVDFQY----------------------- 48

  Fly   100 PLSSSDGLKSRNNTIMSTLVISKIIDEVESPLEKGLTPGPEVTNTSQVVLHRKRKEVVQNIPLFP 164
                .||   .|.|:.:..|:.     :|:...:.:|....:||.||..|
Human    49 ----FDG---ANGTLRNVSVLL-----LEANTNQTVTTKYLLTNQSQGTL--------------- 86

  Fly   165 DPRFNVTQVTVPCQTFLIGGRYEMQVVSNLKSVNRSEVTTTLVPAQDERLHQTLDVRWP------ 223
              :|.       |..|...|.|...:.        .|.|....|.........|.|.||
Human    87 --KFE-------CFYFKEAGDYWFTMT--------PEATDNSTPFPWWEKSAFLKVEWPVFHVDL 134

  Fly   224 --SAEMIVSPVRLKTYPKHPVEVTLRFPEVNCNQSGSLALPEFWLELIYCGKDRSCNRNITPTSV 286
              ||:......::..:...|:   ..||         :..|...:::|:........||......
Human   135 NRSAKAAEGTFQVGLFTSQPL---CPFP---------VDKPNIVVDVIFTNSLPEARRNSRQPLE 187

  Fly   287 LFAEQIRGFPKNKSLHLGCELFGLAGNYAVQLRPMIPAQNVPTTRRLLSVDWSDEFVFNVYARSI 351
            :...:.....:.:.:..||...|......|.|: ::...:|.|:..  .:|.:.:|.:.:.....
Human   188 IRTSKRTELAQGQWVEFGCAPLGPEAYVTVVLK-LLGRDSVITSTG--PIDLAQKFGYKLVMVPE 249

  Fly   352 FPCDPHTGIGVLYEYPGCILEQGDRVRLYARLRADVASLKPPTSLHYVSEQRVVKSQHSLYFACE 416
            ..|:  :|:.|....|.|...|| .|.::..     |...|.....:::|..:...:....|.|.
Human   250 LTCE--SGVEVTVLPPPCTFVQG-VVTVFKE-----APRYPGKRTIHLAENSLPLGERRTIFNCT 306

  Fly   417 HFSEKYVEYCFVYVSQAISGAVADVRMDCVPTLPVSDSDTGGWGPWSEWTPCSTNCLGGTRNRYR 481
            .|.....:|||.:...:.|...|  :.:|:    :...:|..||.|..|:.||..|..|.|.|.|
Human   307 LFDMGKNKYCFDFGISSRSHFSA--KEECM----LIQRNTETWGLWQPWSQCSATCGDGVRERRR 365

  Fly   482 FCDSPPPRYGAKFCEGPSVETQKCGKSIADTWDCIYETSGTVITKENSTEVSQEIGPGCRCGCIV 546
            .|.:..|  .:..|.|.|:|...|...     :|       ...:.:|....|..||
Human   366 VCLTSFP--SSPVCPGMSLEASLCSLE-----EC-------AAFQPSSPSPLQPQGP-------- 408

  Fly   547 HLGSSKPKRIIAGATQSCPGRSFWLIQVDGEESISLALSFLR-LPCAT----------QYIKVRD 600
                .|...|:     :..|.|..|..:.....|:|...|.| ..|:|          .:.|..|
Human   409 ----VKSNNIV-----TVTGISLCLFIIIATVLITLWRRFGRPAKCSTPARHNSIHSPSFRKNSD 464

  Fly   601 GPSLSSTLLVELNGGGLILKGAGVPVVVDSTGGQLLVEFS-AGDGPAGNATQEASPACTG----- 659
            ..::..  |.|..|                       .|| .||||.|      ||..||
Human   465 EENICE--LSEQRG-----------------------SFSDGGDGPTG------SPGDTGIPLTY 498

  Fly   660 ----------------GFMANVQQ--------RLATRS------------------SNSSIT--- 679
                            .|.:|.|:        |||.:.                  |.|.:|
Human   499 RRSGPVPPEDDASGSESFQSNAQKIIPPLFSYRLAQQQLKEMKKKGLTETTKVYHVSQSPLTDTA 563

  Fly   680 ---------------LVAATRLSGKTR-------SVVHKSMSRLRFTLVHLSAMIFASIIIIISS 722
                           ..||.:...|:.       |...:..|||...:...|..|..|..:|..|
Human   564 IDAAPSAPLDLESPEEAAANKFRIKSPFPEQPAVSAGERPPSRLDLNVTQASCAISPSQTLIRKS 628

  Fly   723 LLGAQYVVRYRKYHLAVARRQDEGSRLHTPRASL-------SSLQGPP--SRAMSTTTLLSEVIY 778
                      :..|  |..|.....|.|...|..       .:.|..|  .|:|||.|......|
Human   629 ----------QARH--VGSRGGPSERSHARNAHFRRTASFHEARQARPFRERSMSTLTPRQAPAY 681

  Fly   779 MVKMRPKHHLRHSILRESVDAENLTKETE-FKE-SDSQGMLAKCAEIKELGSSASMVTLRNERSS 841
            ..:.|...........:|..|....::.| |:| |.::|.|....:...||             .
Human   682 SSRTRTCEQAEDRFRPQSRGAHLFPEKLEHFQEASGTRGPLNPLPKSYTLG-------------Q 733

  Fly   842 PARSLDTGSIIGSPSSAEAELAAVHSRSE---SKDSPSDEPIEPPSCKDSARDSESIISSGMSSL 903
            |.|..|.|       ..:|.|.|...|:|   ::..||      ||.|..:|...|.|
Human   734 PLRKPDLG-------DHQAGLVAGIERTEPHRARRGPS------PSHKSVSRKQSSPI------- 778

  Fly   904 CNSPPMNSKRLSKYS 918
              ||..|.:|:|..|
Human   779 --SPKDNYQRVSSLS 791

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gogo	NP_649200.2	TSP1	459..505	CDD:214559	17/45 (38%)
		CUB	<570..640	CDD:294042	12/80 (15%)
		AKAP2_C	1049..>1146	CDD:291950
THSD1	NP_061146.1	TSP1	343..392	CDD:214559	18/55 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	444..517		18/103 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	624..799		50/215 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR16311
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010