DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rdgC and PPZ1

DIOPT Version :9

Sequence 1:	NP_536738.3	Gene:	rdgC / 40224	FlyBaseID:	FBgn0265959	Length:	746	Species:	Drosophila melanogaster
Sequence 2:	NP_013696.1	Gene:	PPZ1 / 854992	SGDID:	S000004478	Length:	692	Species:	Saccharomyces cerevisiae

Alignment Length:	561	Identity:	152/561 - (27%)
Similarity:	237/561 - (42%)	Gaps:	103/561 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 TDDDG----------KRRS-SSVEDASSCRSSEIERVGASMQTLGPNGQPQSSAAQ--------- 54
            ||||.          ||.| ||....||.||..:.|..:.:....||....||..|
Yeast   171 TDDDNDDKDNDISHTKRFSRSSNSRPSSIRSGSVSRRKSDVTHEEPNNGSYSSNNQENYLVQALT 235

  Fly    55 -TSTRASSLLQLFQRRGWCKHFRKPLRGMSASRAEKTIRAAIFIQKW------YRRHQARREMQR 112
             :::.||||           |.||...|...:.|..|...:..:.|.      |....:...:..
Yeast   236 RSNSHASSL-----------HSRKSSFGSDGNTAYSTPLNSPGLSKLTDHSGEYFTSNSTSSLNH 289

  Fly   113 RCNWQIFQNLEYASEQDQAELYKFFNDLIKHMPQAAGRKNQYQGSAHVSVLDDKDDLVEEFGDIV 177
            ..:..|:.: ::.|..|..|.....:::...|.....:.|        ::.|.|.|..|||.||:
Yeast   290 HSSRDIYPS-KHISNDDDIENSSQLSNIHASMENVNDKNN--------NITDSKKDPNEEFNDIM 345

  Fly   178 NA--------KIELPIRKNH-IDLLIDV-FRKKRGNRLHPK-----YVALILREAAKSLKQLPNI 227
            .:        |.:.||..:. |..|:|. :..||...:..|     .:.:..||...|...|..:
Yeast   346 QSSGNKNAPKKFKKPIDIDETIQKLLDAGYAAKRTKNVCLKNNEILQICIKAREIFLSQPSLLEL 410

  Fly   228 SPVSTAVSQQVTVCGDLHGKLDDLLVVLHKNGLPSSSNPYVFNGDFVDRGKRGLEVLLLLLSLYL 292
            ||       .|.:.||:||:..|||.:..|.|.|.||| |:|.||:|||||:.||.:|||....:
Yeast   411 SP-------PVKIVGDVHGQYGDLLRLFTKCGFPPSSN-YLFLGDYVDRGKQSLETILLLFCYKI 467

  Fly   293 AFPNAVFLNRGNHEDSVMNARYGFIREVESKYPRNHKRILAFIDEVYRWLPLGSVLNSRVLIVHG 357
            .:|...||.|||||.:.:...|||..|.:.:.  |.|....||| .:..|||.:::..::..|||
Yeast   468 KYPENFFLLRGNHECANVTRVYGFYDECKRRC--NIKIWKTFID-TFNTLPLAAIVAGKIFCVHG 529

  Fly   358 GFSDSTSLDLIKSIDRGKYVSILRPPLTDGEPLDKTEWQQIFDIMWSDPQATMGCVPNTLRGAGV 422
            |.|     .::.|:|..::|.         .|.|..::..|.|::||||..:.....:..||...
Yeast   530 GLS-----PVLNSMDEIRHVV---------RPTDVPDFGLINDLLWSDPTDSPNEWEDNERGVSY 580

  Fly   423 WFGPDVTDNFLQRHRLSYVIRSHECKPNGHEFMHDNKIITIFSASNYYAIGSNKGAYIRLNNQLM 487
            .:.....:.||.:.....|.|:|....:|:||.:|..::|:|||.||.....|.||.:.::..|:
Yeast   581 CYNKVAINKFLNKFGFDLVCRAHMVVEDGYEFFNDRSLVTVFSAPNYCGEFDNWGAVMSVSEGLL 645

  Fly   488 PHFVQYISAASQTKRLSFKQRMGIVESSALKELAVRMRDHR 528
            ..|                :.:..::|:|||::..:.|..|
Yeast   646 CSF----------------ELLDPLDSAALKQVMKKGRQER 670

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rdgC	NP_536738.3	IQ	89..111	CDD:197470	3/27 (11%)
		MPP_RdgC	184..494	CDD:277364	100/316 (32%)
		EFh	616..681	CDD:238008
PPZ1	NP_013696.1	MPP_PP1_PPKL	362..653	CDD:277359	98/331 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000018
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000