DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rdgC and CNA1

DIOPT Version :9

Sequence 1:	NP_536738.3	Gene:	rdgC / 40224	FlyBaseID:	FBgn0265959	Length:	746	Species:	Drosophila melanogaster
Sequence 2:	NP_013537.1	Gene:	CNA1 / 851153	SGDID:	S000004425	Length:	553	Species:	Saccharomyces cerevisiae

Alignment Length:	609	Identity:	149/609 - (24%)
Similarity:	232/609 - (38%)	Gaps:	182/609 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   163 LDDKDDLVE---EFGDIVNAK----IELPIRKNHIDLLIDVFRKKRG--------------NRLH 206
            :|.|.||.:   |.|.:::.|    ..:|.....|....:||..|.|              .||.
Yeast    22 VDRKKDLTKYELENGKVISTKDRPIASVPAITGKIPSDEEVFDSKTGLPNHSFLREHFFHEGRLS 86

  Fly   207 PKYVALILREAAKSLKQLPNISPVSTAVSQQVTVCGDLHGKLDDLLVVLHKNGLPSSSNPYVFNG 271
            .:....||..:..:|.:.||:    ..:...:|:|||:||:..|||.:....|.|:..: |:|.|
Yeast    87 KEQAIKILNMSTVALSKEPNL----LKLKAPITICGDIHGQYYDLLKLFEVGGDPAEID-YLFLG 146

  Fly   272 DFVDRGKRGLEVLLLLLSLYLAFPNAVFLNRGNHEDSVMNARYGFIREVESKYPRNHKRILAFID 336
            |:||||....|.|:.|.||.|......::.|||||...:.:.:.|..|:..||..
Yeast   147 DYVDRGAFSFECLIYLYSLKLNNLGRFWMLRGNHECKHLTSYFTFKNEMLHKYDM---------- 201

  Fly   337 EVY-------RWLPLGSVLNSRVLIVHGGFSDSTSLDLIKSIDRGKYVSILRPPLTDGEPLDKTE 394
            |||       ..|||.:::|.:...||||.|..     :||::....::..|...:.|
Yeast   202 EVYDACCRSFNVLPLAALMNGQYFCVHGGISPE-----LKSVEDVNKINRFREIPSRG------- 254

  Fly   395 WQQIFDIMWSDP--------------QATMGCVPNTLRGAGVWFGPDVTDNFLQRHRLSYVIRSH 445
              .:.|::|:||              |:....|||:|||....|....:..||:.:.|..:||:|
Yeast   255 --LMCDLLWADPVENYDDARDGSEFDQSEDEFVPNSLRGCSFAFTFKASCKFLKANGLLSIIRAH 317

  Fly   446 ECKPNGHEFMHDNKI------ITIFSASNYYAIGSNKGAYIRLNNQLM--------PH------- 489
            |.:..|:....:||:      ||:|||.||.....||.|.::....:|        ||
Yeast   318 EAQDAGYRMYKNNKVTGFPSLITMFSAPNYLDTYHNKAAVLKYEENVMNIRQFHMSPHPYWLPDF 382

  Fly   490 ---------FV-----------------QYISAASQTKRL--SFKQRMGIVESSALKELAVRMRD 526
                     ||                 |.:...|:.|..  :.|.|     ::|.||......:
Yeast   383 MDVFTWSLPFVGEKVTSMLVSILNICSEQELDPESEPKAAEETVKAR-----ANATKETGTPSDE 442

  Fly   527 HRDE--LEDEFRKYDPKDSGYISISHWCKVMEN----VTKLGLPWRLLRDKLAPGTDSQKVNYNR 585
            ....  ||||.|:               |.:.|    :.|:...:.:||:      :|:||.|.:
Yeast   443 KASSAILEDETRR---------------KALRNKILAIAKVSRMFSVLRE------ESEKVEYLK 486

  Fly   586 TLDLLDTDVILEAEADGMSVMDALYANKASLVAIFNIIDADNSGEITLDEFETA--IDLLVAHMP 648
            |::.            |:....||......|             ..||..||.|  .||:...:|
Yeast   487 TMNA------------GVLPRGALARGTEGL-------------NETLSTFEKARKEDLINEKLP 526

  Fly   649 GAYSKAEMLEKCRMMD--LNGDGK 670
            .:.|:.|. ||.:..:  |.|..|
Yeast   527 PSLSEVEQ-EKIKYYEKILKGAEK 549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rdgC	NP_536738.3	IQ	89..111	CDD:197470
		MPP_RdgC	184..494	CDD:277364	101/391 (26%)
		EFh	616..681	CDD:238008	16/59 (27%)
CNA1	NP_013537.1	MPP_PP2B	70..381	CDD:277361	92/339 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157341459
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930