Protein Alignment rdgC and Ppp5c

DIOPT Version :10

• Sequence 1: NP_536738.3
• Gene: rdgC / 40224
• FlyBaseID: FBgn0265959
• Length: 746
• Species: Drosophila melanogaster
• Sequence 2: NP_113917.1
• Gene: Ppp5c / 65179
• RGDID: 68415
• Length: 499
• Species: Rattus norvegicus
• Alignment Length: 513
• Identity: 162/513 - (31%)
• Similarity: 245/513 - (47%)
• Gaps: 94/513 - (18%)

  Fly     8 LRTDDDGKRRSSSVEDASSCRSSEIERVGASMQTLGPNGQPQSSAAQTSTRASSLLQLFQRRGWC 72
            |:|..:...::...|:|....|..||        |.|     |:|.....|:.:.|
  Rat    31 LKTQANDYFKAKDYENAIKFYSQAIE--------LNP-----SNAIYYGNRSLAYL--------- 73

  Fly    73 KHFRKPLRGMSASRAEKTIRA-AIFIQKWYRRHQARREMQRRCNWQIFQNLEYASEQDQAELYKF 136
               |....|.:...|.:.|.. ..:|:.:|||..:...:.:      |:    |:.:|
  Rat    74 ---RTECYGYALGDATRAIELDKKYIKGYYRRAASNMALGK------FR----AALRD------- 118

  Fly   137 FNDLIKHMPQAAGRKNQYQ----------------GSAH-VSVLDDKD----DLVEEFG--DIVN 178
            :..::|..|.....|.:||                |..| .||:|..|    .:.:|:.  .:.:
  Rat   119 YETVVKVKPNDKDAKMKYQECSKIVKQKAFERAIAGDEHRRSVVDSLDIESMTIEDEYSGPKLED 183

  Fly   179 AKIELPIRKNHIDLLIDVFRKKRGNRLHPKYVALILREAAKSLKQLPNISPVSTAVSQQVTVCGD 243
            .|:.:...|:    |:..::.::  :||.|....||.:..:.|.:|..:...:...::::|||||
  Rat   184 GKVTITFMKD----LMQWYKDQK--KLHRKCAYQILVQVKEVLCKLSTLVETTLKETEKITVCGD 242

  Fly   244 LHGKLDDLLVVLHKNGLPSSSNPYVFNGDFVDRGKRGLEVLLLLLSLYLAFPNAVFLNRGNHEDS 308
            .||:..|||.:...|||||.:|||:|||||||||...:||:|.|....|.:|:...|.|||||..
  Rat   243 THGQFYDLLNIFELNGLPSETNPYIFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLLRGNHETD 307

  Fly   309 VMNARYGFIREVESKYPRNHKRILAFIDEVYRWLPLGSVLNSRVLIVHGG-FS-DSTSLDLIKSI 371
            .||..|||..||::||.   .::.....||:.||||...:|.:|||:||| || |..:||.|:.|
  Rat   308 NMNQIYGFEGEVKAKYT---AQMYELFSEVFEWLPLAQCINGKVLIMHGGLFSEDGVTLDDIRKI 369

  Fly   372 DRGKYVSILRPPLTDGEPLDKTEWQQIFDIMWSDPQATMGCVPNTLRGAGVWFGPDVTDNFLQRH 436
            :|.:     :||  |..|:        .|::|||||...|...:. ||....||||||..||:.:
  Rat   370 ERNR-----QPP--DSGPM--------CDLLWSDPQPQNGRSVSK-RGVSCQFGPDVTKAFLEEN 418

  Fly   437 RLSYVIRSHECKPNGHEFMHDNKIITIFSASNYYAIGSNKGAYIRL-NNQLMPHFVQY 493
            :|.|:|||||.|..|:|..|..:.:|:|||.||.....||.:||.| .:.|.|.|.|:
  Rat   419 QLDYIIRSHEVKAEGYEVAHGGRCVTVFSAPNYCDQMGNKASYIHLQGSDLRPQFHQF 476

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rdgC	NP_536738.3	IQ	89..111	CDD:197470	5/22 (23%)
		MPP_RdgC	184..494	CDD:277364	125/313 (40%)
		FRQ1	527..681	CDD:444056
		EFh	616..681	CDD:238008
Ppp5c	NP_113917.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23
		NlpI	<19..>129	CDD:443815	26/139 (19%)
		TPR 1	28..61		9/42 (21%)
		TPR repeat	28..56	CDD:276809	5/24 (21%)
		TPR repeat	61..91	CDD:276809	7/41 (17%)
		TPR 2	62..95		7/44 (16%)
		TPR 3	96..129		9/49 (18%)
		TPR repeat	96..124	CDD:276809	7/44 (16%)
		MPP_PP5_C	176..491	CDD:277362	126/326 (39%)
		Catalytic	200..499		123/298 (41%)
		Required for autoinhibition. /evidence=ECO:0000269|PubMed:11523989	495..499