DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rdgC and PPP6C

DIOPT Version :9

Sequence 1:	NP_536738.3	Gene:	rdgC / 40224	FlyBaseID:	FBgn0265959	Length:	746	Species:	Drosophila melanogaster
Sequence 2:	NP_001116827.1	Gene:	PPP6C / 5537	HGNCID:	9323	Length:	342	Species:	Homo sapiens

Alignment Length:	277	Identity:	96/277 - (34%)
Similarity:	143/277 - (51%)	Gaps:	50/277 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   209 YVA-LILREAAKSLKQLPNISPVSTAVSQQVTVCGDLHGKLDDLLVVLHKNGLPSSSNPYVFNGD 272
            ||. |:|.|:        |:.||||    .||||||:||:..||..:....|....:| |:|.||
Human    67 YVCDLLLEES--------NVQPVST----PVTVCGDIHGQFYDLCELFRTGGQVPDTN-YIFMGD 118

  Fly   273 FVDRGKRGLEVLLLLLSLYLAFPNAVFLNRGNHEDSVMNARYGFIREVESKYPRNHKRILAFIDE 337
            |||||...||....||:|...:|:.:.|.|||||...:...|||..|.::||  .:.....:..:
Human   119 FVDRGYYSLETFTYLLALKAKWPDRITLLRGNHESRQITQVYGFYDECQTKY--GNANAWRYCTK 181

  Fly   338 VYRWLPLGSVLNSRVLIVHGGFS-DSTSLDLIKSIDRGKYVSILRPPLTDGEPLDKTEWQQI--- 398
            |:..|.:.::::.::|.||||.| |..:||.|::|:|.                     |:|
Human   182 VFDMLTVAALIDEQILCVHGGLSPDIKTLDQIRTIERN---------------------QEIPHK 225

  Fly   399 ---FDIMWSDPQ--ATMGCVPNTLRGAGVWFGPDVTDNFLQRHRLSYVIRSHECKPNGHEFMHDN 458
               .|::||||:  .|....|   ||||..||..||:.|:..:.|..:.|:|:....|::||.|.
Human   226 GAFCDLVWSDPEDVDTWAISP---RGAGWLFGAKVTNEFVHINNLKLICRAHQLVHEGYKFMFDE 287

  Fly   459 KIITIFSASNY-YAIGS 474
            |::|::||.|| |..|:
Human   288 KLVTVWSAPNYCYRCGN 304

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rdgC	NP_536738.3	IQ	89..111	CDD:197470
		MPP_RdgC	184..494	CDD:277364	96/277 (35%)
		EFh	616..681	CDD:238008
PPP6C	NP_001116827.1	MPP_PP2A_PP4_PP6	5..326	CDD:277360	96/277 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000018
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910