DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rdgC and PPP3CB

DIOPT Version :9

Sequence 1:	NP_536738.3	Gene:	rdgC / 40224	FlyBaseID:	FBgn0265959	Length:	746	Species:	Drosophila melanogaster
Sequence 2:	NP_001135825.1	Gene:	PPP3CB / 5532	HGNCID:	9315	Length:	525	Species:	Homo sapiens

Alignment Length:	327	Identity:	101/327 - (30%)
Similarity:	158/327 - (48%)	Gaps:	54/327 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   185 IRKNHIDLLIDVFRKKRGNRLHPKYVALILREAAKSLKQLPNISPVSTAVSQQVTVCGDLHGKLD 249
            :.|||:        .|.| |:..:....|:.|.|..|::    ......|...:|||||:||:..
Human    54 VLKNHL--------VKEG-RVDEEIALRIINEGAAILRR----EKTMIEVEAPITVCGDIHGQFF 105

  Fly   250 DLLVVLHKNGLPSSSNPYVFNGDFVDRGKRGLEVLLLLLSLYLAFPNAVFLNRGNHEDSVMNARY 314
            ||:.:....|.|:::. |:|.||:||||...:|.:|.|..|.:.:|:.:||.|||||...:...:
Human   106 DLMKLFEVGGSPANTR-YLFLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGNHECRHLTEYF 169

  Fly   315 GFIREVESKYPRNHKRILAFIDEVYRWLPLGSVLNSRVLIVHGGFS-DSTSLDLIKSIDRGKYVS 378
            .|.:|.:.||   .:|:.....|.:..|||.::||.:.|.||||.| :..:||.|:.:||.|
Human   170 TFKQECKIKY---SERVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLDDIRRLDRFK--- 228

  Fly   379 ILRPPLTDGEPLDKTEWQQIFDIMWSDPQATMG-------CVPNTLRGAGVWFGPDVTDNFLQRH 436
              .||          .:..:.|::||||....|       ...||:||...::.......|||.:
Human   229 --EPP----------AFGPMCDLLWSDPSEDFGNEKSQEHFSHNTVRGCSYFYNYPAVCEFLQNN 281

  Fly   437 RLSYVIRSHECKPNGHEFMHDNK------IITIFSASNYYAIGSNKGAYIRLNNQLM-------- 487
            .|..:||:||.:..|:.....::      :||||||.||..:.:||.|.::..|.:|
Human   282 NLLSIIRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCS 346

  Fly   488 PH 489
            ||
Human   347 PH 348

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rdgC	NP_536738.3	IQ	89..111	CDD:197470
		MPP_RdgC	184..494	CDD:277364	101/327 (31%)
		EFh	616..681	CDD:238008
PPP3CB	NP_001135825.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25
		MPP_PP2B	50..354	CDD:277361	101/327 (31%)
		Catalytic. /evidence=ECO:0000305	65..356		95/307 (31%)
		SAPNY motif. /evidence=ECO:0000250\|UniProtKB:Q08209	316..320		2/3 (67%)
		Calcineurin B binding. /evidence=ECO:0000269\|PubMed:26794871	357..379
		Calmodulin-binding. /evidence=ECO:0000269\|PubMed:26794871	402..416
		Autoinhibitory segment. /evidence=ECO:0000269\|PubMed:26794871	417..424
		Autoinhibitory domain. /evidence=ECO:0000269\|PubMed:26794871	475..497
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910