DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rdgC and PPP3CA

DIOPT Version :9

Sequence 1:	NP_536738.3	Gene:	rdgC / 40224	FlyBaseID:	FBgn0265959	Length:	746	Species:	Drosophila melanogaster
Sequence 2:	NP_000935.1	Gene:	PPP3CA / 5530	HGNCID:	9314	Length:	521	Species:	Homo sapiens

Alignment Length:	325	Identity:	101/325 - (31%)
Similarity:	159/325 - (48%)	Gaps:	47/325 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   187 KNHIDLLIDVFRKKRGNRLHPKYVALILREAAKSLKQLPNISPVSTAVSQQVTVCGDLHGKLDDL 251
            |..:|:|.....|:  .||.......|:.|.|..|:|..|:..:..    .||||||:||:..||
Human    40 KPRVDILKAHLMKE--GRLEESVALRIITEGASILRQEKNLLDIDA----PVTVCGDIHGQFFDL 98

  Fly   252 LVVLHKNGLPSSSNPYVFNGDFVDRGKRGLEVLLLLLSLYLAFPNAVFLNRGNHEDSVMNARYGF 316
            :.:....|.|:::. |:|.||:||||...:|.:|.|.:|.:.:|..:||.|||||...:...:.|
Human    99 MKLFEVGGSPANTR-YLFLGDYVDRGYFSIECVLYLWALKILYPKTLFLLRGNHECRHLTEYFTF 162

  Fly   317 IREVESKYPRNHKRILAFIDEVYRWLPLGSVLNSRVLIVHGGFS-DSTSLDLIKSIDRGKYVSIL 380
            .:|.:.||   .:|:.....:.:..|||.:::|.:.|.||||.| :..:||.|:.:||.|
Human   163 KQECKIKY---SERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEINTLDDIRKLDRFK----- 219

  Fly   381 RPPLTDGEPLDKTEWQQIFDIMWSDPQATMG-------CVPNTLRGAGVWFGPDVTDNFLQRHRL 438
            .||          .:..:.||:||||....|       ...||:||...::.......|||.:.|
Human   220 EPP----------AYGPMCDILWSDPLEDFGNEKTQEHFTHNTVRGCSYFYSYPAVCEFLQHNNL 274

  Fly   439 SYVIRSHECKPNGHEFMHDNK------IITIFSASNYYAIGSNKGAYIRLNNQLM--------PH 489
            ..::|:||.:..|:.....::      :||||||.||..:.:||.|.::..|.:|        ||
Human   275 LSILRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPH 339

Fly 490 489
Human 340 339

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rdgC	NP_536738.3	IQ	89..111	CDD:197470
		MPP_RdgC	184..494	CDD:277364	101/325 (31%)
		EFh	616..681	CDD:238008
PPP3CA	NP_000935.1	MPP_PP2B	41..345	CDD:277361	100/324 (31%)
		Catalytic. /evidence=ECO:0000305	56..340		96/307 (31%)
		SAPNY motif. /evidence=ECO:0000305\|PubMed:26248042	307..311		2/3 (67%)
		Interaction with PxIxIF motif in substrate. /evidence=ECO:0000269\|PubMed:17498738, ECO:0000269\|PubMed:17502104, ECO:0000269\|PubMed:22343722, ECO:0000269\|PubMed:23468591, ECO:0000269\|PubMed:26248042	327..336		1/8 (13%)
		Calcineurin B binding. /evidence=ECO:0000269\|PubMed:12218175, ECO:0000269\|PubMed:12357034, ECO:0000269\|PubMed:17498738, ECO:0000269\|PubMed:23468591, ECO:0000269\|PubMed:27974827, ECO:0000269\|PubMed:8524402	341..369
		Calmodulin-binding. /evidence=ECO:0000269\|PubMed:18384083, ECO:0000269\|PubMed:19404396, ECO:0000269\|PubMed:25144868, ECO:0000269\|Ref.31	392..406
		Autoinhibitory segment. /evidence=ECO:0000250\|UniProtKB:P16298	407..414
		Autoinhibitory domain. /evidence=ECO:0000269\|PubMed:8524402	465..487
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	475..521
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910