DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rdgC and PPP1CC

DIOPT Version :9

Sequence 1:	NP_536738.3	Gene:	rdgC / 40224	FlyBaseID:	FBgn0265959	Length:	746	Species:	Drosophila melanogaster
Sequence 2:	XP_011536806.1	Gene:	PPP1CC / 5501	HGNCID:	9283	Length:	362	Species:	Homo sapiens

Alignment Length:	324	Identity:	105/324 - (32%)
Similarity:	163/324 - (50%)	Gaps:	35/324 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   187 KNHIDLLIDVFRKKRGNR------LHPKYV-ALILREAAKSLKQLPNISPVSTAVSQQVTVCGDL 244
            |.:||.:|....:.||::      |....: .|.|:.....|.|     |:...:...:.:|||:
Human     6 KLNIDSIIQRLLEVRGSKPGKNVQLQENEIRGLCLKSREIFLSQ-----PILLELEAPLKICGDI 65

  Fly   245 HGKLDDLLVVLHKNGLPSSSNPYVFNGDFVDRGKRGLEVLLLLLSLYLAFPNAVFLNRGNHEDSV 309
            ||:..|||.:....|.|..|| |:|.||:|||||:.||.:.|||:..:.:|...||.|||||.:.
Human    66 HGQYYDLLRLFEYGGFPPESN-YLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECAS 129

  Fly   310 MNARYGFIREVESKYPRNHKRILAFIDEVYRWLPLGSVLNSRVLIVHGGFS-DSTSLDLIKSIDR 373
            :|..|||..|.:.:|  |.|....|.| .:..||:.::::.::...|||.| |..|::.|:.|.|
Human   130 INRIYGFYDECKRRY--NIKLWKTFTD-CFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMR 191

  Fly   374 GKYVSILRPPLTDGEPLDKTEWQQIFDIMWSDP-QATMGCVPNTLRGAGVWFGPDVTDNFLQRHR 437
                           |.|..:...:.|::|||| :..:|...|. ||....||.:|...||.:|.
Human   192 ---------------PTDVPDQGLLCDLLWSDPDKDVLGWGEND-RGVSFTFGAEVVAKFLHKHD 240

  Fly   438 LSYVIRSHECKPNGHEFMHDNKIITIFSASNYYAIGSNKGAYIRLNNQLMPHFVQYISAASQTK 501
            |..:.|:|:...:|:||....:::|:|||.||.....|.||.:.::..||..| |.:..|.:.|
Human   241 LDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSF-QILKPAEKKK 303

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rdgC	NP_536738.3	IQ	89..111	CDD:197470
		MPP_RdgC	184..494	CDD:277364	103/315 (33%)
		EFh	616..681	CDD:238008
PPP1CC	XP_011536806.1	PTZ00480	6..315	CDD:185658	105/324 (32%)
PPP1CC	XP_011536806.1	MPP_PP1_PPKL	8..298	CDD:277359	102/315 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000018
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910