Protein Alignment rdgC and PPEF1

DIOPT Version :10

• Sequence 1: NP_536738.3
• Gene: rdgC / 40224
• FlyBaseID: FBgn0265959
• Length: 746
• Species: Drosophila melanogaster
• Sequence 2: NP_006231.2
• Gene: PPEF1 / 5475
• HGNCID: 9243
• Length: 653
• Species: Homo sapiens
• Alignment Length: 652
• Identity: 262/652 - (40%)
• Similarity: 393/652 - (60%)
• Gaps: 54/652 - (8%)

  Fly    81 GMSAS-----RAEKTIRAAIFIQKWYRRHQARREMQRRCNWQIFQNLEYASEQDQAELYKFFNDL 140
            |.|:|     |::.::|||:.||.|||.::||.:.::.....|||::|||.||.|.:|..||:.:
Human     2 GCSSSSTKTRRSDTSLRAALIIQNWYRGYKARLKARQHYALTIFQSIEYADEQGQMQLSTFFSFM 66

  Fly   141 IKHMPQAAGRKNQYQGSAHVSVLDDKD--DLVE--EFGDIVNA-KIELPIRKNHIDLLIDVFRKK 200
            :::.......:.:.:..:..|..|.:|  |.|:  :..|..|. :::.|:....||||::.|:::
Human    67 LENYTHIHKEELELRNQSLESEQDMRDRWDYVDSIDVPDSYNGPRLQFPLTCTDIDLLLEAFKEQ 131

  Fly   201 RGNRLHPKYVALILREAAKSLKQLPNISPVSTAVSQQVTVCGDLHGKLDDLLVVLHKNGLPSSSN 265
            :  .||..||..:|.|..|.|||:||.:.:.|:.|::||:|||||||||||.::.:||||||..|
Human   132 Q--ILHAHYVLEVLFETKKVLKQMPNFTHIQTSPSKEVTICGDLHGKLDDLFLIFYKNGLPSERN 194

  Fly   266 PYVFNGDFVDRGKRGLEVLLLLLSLYLAFPNAVFLNRGNHEDSVMNARYGFIREVESKYPRNHKR 330
            |||||||||||||..:|:|::|...:|.:||.:.||||||||.:||.||||.:|:..||..:.||
Human   195 PYVFNGDFVDRGKNSIEILMILCVSFLVYPNDLHLNRGNHEDFMMNLRYGFTKEILHKYKLHGKR 259

  Fly   331 ILAFIDEVYRWLPLGSVLNSRVLIVHGGFSDSTSLDLIKSIDRGKYVSILRPPL----------- 384
            ||..::|.|.|||:|:::::.:|::|||.|::|.|:|:..::|.|..|:|.||.
Human   260 ILQILEEFYAWLPIGTIVDNEILVIHGGISETTDLNLLHRVERNKMKSVLIPPTETNRDHDTDSK 324

  Fly   385 ---------------TDGEP---LDKTEWQQIFDIMWSDPQATMGCVPNTLRGAGVWFGPDVTDN 431
                           |:|.|   |.:.||:||.||:||||:...||.|||.||.|.:||||||..
Human   325 HNKVGVTFNAHGRIKTNGSPTEHLTEHEWEQIIDILWSDPRGKNGCFPNTCRGGGCYFGPDVTSK 389

  Fly   432 FLQRHRLSYVIRSHECKPNGHEFMHDNKIITIFSASNYYAIGSNKGAYIRLNNQLMPHFVQYISA 496
            .|.:::|..:||||||||.|:|..||.|::|||||||||..|||:||||:|.:...|.|.||
Human   390 ILNKYQLKMLIRSHECKPEGYEICHDGKVVTIFSASNYYEEGSNRGAYIKLCSGTTPRFFQY--- 451

  Fly   497 ASQTKRLSF---KQRMGIVESSALKELAVRMRDHRDELEDEFRKYDPKDSGYISISHWCKVMENV 558
             ..||...|   :||:..:|:||:|.|..|:...:.:|...|:..|.:.||.:|:|.|...|||:
Human   452 -QVTKATCFQPLRQRVDTMENSAIKILRERVISRKSDLTRAFQLQDHRKSGKLSVSQWAFCMENI 515

  Fly   559 TKLGLPWRLLRDKLAPGTDSQKVNYNRTLDLLDTD-VILEAEADGMSVMDALYANKASLVAIFNI 622
            ..|.||||.|...|.....:..|.|..:...:..: .:.||.:   ::::.||..::.|..|||.
Human   516 LGLNLPWRSLSSNLVNIDQNGNVEYMSSFQNIRIEKPVQEAHS---TLVETLYRYRSDLEIIFNA 577

  Fly   623 IDADNSGEITLDEFETAIDLLVAHMPGAYSKAEMLEKCRMMDLNGDGKVDLNEFLEAFRLSDLHR 687
            ||.|:||.|:::||.....|..:|.......:::.:...:||||.||.:|.||||:||.:  :||
Human   578 IDTDHSGLISVEEFRAMWKLFSSHYNVHIDDSQVNKLANIMDLNKDGSIDFNEFLKAFYV--VHR 640

  Fly   688 KE 689
            .|
Human   641 YE 642

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rdgC	NP_536738.3	IQ	89..111	CDD:197470	10/21 (48%)
		MPP_RdgC	184..494	CDD:277364	163/338 (48%)
		FRQ1	527..681	CDD:444056	50/154 (32%)
		EFh	616..681	CDD:238008	26/64 (41%)
PPEF1	NP_006231.2	MPP_RdgC	115..452	CDD:277364	164/342 (48%)
		Catalytic	121..455		163/339 (48%)
		FRQ1	487..635	CDD:444056	49/150 (33%)
		EF-hand_7	568..636	CDD:463900	26/67 (39%)
		IQ	18..37	CDD:197470	10/18 (56%)