Protein Alignment rdgC and PPEF2

DIOPT Version :10

• Sequence 1: NP_536738.3
• Gene: rdgC / 40224
• FlyBaseID: FBgn0265959
• Length: 746
• Species: Drosophila melanogaster
• Sequence 2: NP_006230.2
• Gene: PPEF2 / 5470
• HGNCID: 9244
• Length: 753
• Species: Homo sapiens
• Alignment Length: 731
• Identity: 277/731 - (37%)
• Similarity: 389/731 - (53%)
• Gaps: 158/731 - (21%)

  Fly    87 AEKTIRAAIFIQKWYRRHQARREMQRRCNWQIFQNLEYASEQDQAELYKFFNDLIKHMPQAAGRK 151
            ||:..:||..||:||||:.||.||:|||.|.|||::|||.:|||.:|:.||:.|:.|
Human    16 AERAFKAAALIQRWYRRYVARLEMRRRCTWSIFQSIEYAGQQDQVKLHDFFSYLMDH-------- 72

  Fly   152 NQYQGSAHVSVLDDKDDLVEEFGD-----------------------IVNAKIELPIRKNHIDLL 193
              :..|:|    :|:|.|...|.:                       ....::..|:..:|...|
Human    73 --FIPSSH----NDRDFLTRIFTEDRFAQDSEMKKCSDYESIEVPDSYTGPRLSFPLLPDHATAL 131

  Fly   194 IDVFRKKRGNRLHPKYVALILREAAKSLKQLPNISPVSTAVSQQVTVCGDLHGKLDDLLVVLHKN 258
            ::.||.|:  :||.:||..:|.|..|.|.|||||:.|||..|:::||||||||:||||:.:.:||
Human   132 VEAFRLKQ--QLHARYVLNLLYETKKHLVQLPNINRVSTCYSEEITVCGDLHGQLDDLIFIFYKN 194

  Fly   259 GLPSSSNPYVFNGDFVDRGKRGLEVLLLLLSLYLAFPNAVFLNRGNHEDSVMNARYGFIREVESK 323
            ||||....||||||||||||..:|:|::|.:..|.:|....||||||||.::|.||||.:||.:|
Human   195 GLPSPERSYVFNGDFVDRGKDSVEILMILFAFMLVYPKEFHLNRGNHEDHMVNLRYGFTKEVMNK 259

  Fly   324 YPRNHKRILAFIDEVYRWLPLGSVLNSRVLIVHGGFSDSTSLDLIKSIDRGKYVSILR------- 381
            |..:.|.||..:.:|:.||||.::::.:|||:|||.||.|.|:|:..|:|.|.||.:|
Human   260 YKVHGKEILRTLQDVFCWLPLATLIDEKVLILHGGVSDITDLELLDKIERSKIVSTMRCKTRQKS 324

  Fly   382 --------------------------------PPL---------------------TDGEPLDK- 392
                                            .||                     .||..|.:
Human   325 EKQMEEKRRANQKSSAQGPIPWFLPESRSLPSSPLRLGSYKAQKTSRSSSIPCSGSLDGRELSRQ 389

  Fly   393 ----------------------------------------------TEWQQIFDIMWSDPQATMG 411
                                                          .||:|:.||:||||.|..|
Human   390 VRSSVELELERCRQQAGLLVTGEKEEPSRSASEADSEAGELRKPTQEEWRQVVDILWSDPMAQEG 454

  Fly   412 CVPNTLRGAGVWFGPDVTDNFLQRHRLSYVIRSHECKPNGHEFMHDNKIITIFSASNYYAIGSNK 476
            |..||:||.|.:||||||...||::.:.::||||||||.|:||.|:.|::|||||||||.:|||:
Human   455 CKANTIRGGGCYFGPDVTQQLLQKYNMQFLIRSHECKPEGYEFCHNRKVLTIFSASNYYEVGSNR 519

  Fly   477 GAYIRLNNQLMPHFVQYISAASQTKRLSFKQRMGIVESSALKELAVRMRDHRDELEDEFRKYDPK 541
            |||::|...|.||.||| .|...|..|:.:||:..||.|||:.|..::..|..:|..||:|:|..
Human   520 GAYVKLGPALTPHIVQY-QANKVTHTLTMRQRISRVEESALRALREKLFAHSSDLLSEFKKHDAD 583

  Fly   542 DSGYISISHWCKVMENVTKLGLPWRLLRDKLAPGTDSQKVNYNRTLDLLDTDVILEAEADGMSVM 606
            ..|.|::|.|...:|:|..||||||:||.:|...:....:.|...|..|..:. |..|....|::
Human   584 KVGLITLSDWAAAVESVLHLGLPWRMLRPQLVNSSADNMLEYKSWLKNLAKEQ-LSRENIQSSLL 647

  Fly   607 DALYANKASLVAIFNIIDADNSGEITLDEFETAIDLLVAHMPGAYSKAEMLEKC-----RMMDLN 666
            :.||.|:::|..||.|||:|:||.|:||||.....|..:||     ..::.:.|     |.:|.|
Human   648 ETLYRNRSNLETIFRIIDSDHSGFISLDEFRQTWKLFSSHM-----NIDITDDCICDLARSIDFN 707

  Fly   667 GDGKVDLNEFLEAFRL 682
            .||.:|:|||||||||
Human   708 KDGHIDINEFLEAFRL 723

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rdgC	NP_536738.3	IQ	89..111	CDD:197470	11/21 (52%)
		MPP_RdgC	184..494	CDD:277364	164/416 (39%)
		FRQ1	527..681	CDD:444056	60/158 (38%)
		EFh	616..681	CDD:238008	30/69 (43%)
PPEF2	NP_006230.2	IQ	21..40	CDD:197470	11/18 (61%)
		MPP_RdgC	122..537	CDD:277364	165/417 (40%)
		Catalytic	128..540		164/414 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	318..382		2/63 (3%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	409..435		0/25 (0%)
		FRQ1	577..722	CDD:444056	57/150 (38%)
		EFh	657..722	CDD:238008	30/69 (43%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	732..753