DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rdgC and SPBC3F6.01c

DIOPT Version :9

Sequence 1:	NP_536738.3	Gene:	rdgC / 40224	FlyBaseID:	FBgn0265959	Length:	746	Species:	Drosophila melanogaster
Sequence 2:	NP_596740.1	Gene:	SPBC3F6.01c / 2541004	PomBaseID:	SPBC3F6.01c	Length:	473	Species:	Schizosaccharomyces pombe

Alignment Length:	493	Identity:	148/493 - (30%)
Similarity:	230/493 - (46%)	Gaps:	87/493 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 RSCVCLRTDDDGKRRSSSVEDASSCRSSEIERVGASMQTLGPNGQPQSSAAQTSTRASSLLQLFQ 67
            ||...|:::|.|    .::.|||.....:.|...|..:                 ||::.:.:||
pombe    45 RSLAHLKSEDYG----LAINDASKAIECDPEYAKAYFR-----------------RATAHIAIFQ 88

  Fly    68 RRGWCKHFRKPLRGMSASRAEKTIRAAIFIQKWYRRHQARREMQRRCNWQIFQNLEYASEQDQAE 132
            .:.....|||.| .::.|                  ..|.|:..|.|            ||
pombe    89 PKEAVGDFRKAL-ALAPS------------------DPAARKKLREC------------EQ---- 118

  Fly   133 LYKFFNDLIKHMPQAAGRKNQYQGSAHVSVLDDKDDLVEEFGDIVNAKIELPIRKNHIDLLIDVF 197
                   |:|.:.......|....|...::..:..|:..::..::   :|..|.|..::.:.:.|
pombe   119 -------LVKRIRFQEAIHNTEPPSPLANINIEDMDIPSDYDGVI---LEKQITKEFVEDMKERF 173

  Fly   198 RKKRGNRLHPKYVALILREAAKSLKQLPNISPVSTAVSQQVTVCGDLHGKLDDLLVVLHKNGLPS 262
              .:|.:|..|:...|||:..:.|::.|::..:.....:.:.:|||.||:..|||.:...:|.||
pombe   174 --CQGKKLPLKFAYSILRDLKELLEKTPSLIDIPVKGDETLVICGDTHGQYFDLLNIFKLHGPPS 236

  Fly   263 SSNPYVFNGDFVDRGKRGLEVLLLLLSLYLAFPNAVFLNRGNHEDSVMNARYGFIREVESKYPRN 327
            .:|.|:|||||||||....||...|.:..|.:|:|||:||||||...||..|||..|..|||
pombe   237 PTNKYLFNGDFVDRGSWSTEVAFTLYAYKLLYPDAVFINRGNHETDDMNKVYGFEGECRSKY--- 298

  Fly   328 HKRILAFIDEVYRWLPLGSVLNSRVLIVHGG-FS-DSTSLDLIKSIDRGKYVSILRPPLTDGEPL 390
            ::|......|.:..|||||:::...|:|||| || |:.:||.:::|||..    .:.|...|
pombe   299 NERTFNIFSETFSLLPLGSLISDSYLVVHGGLFSDDNVTLDQLRNIDRFS----KKQPGQSG--- 356

  Fly   391 DKTEWQQIFDIMWSDPQATMGCVPNTLRGAGVWFGPDVTDNFLQRHRLSYVIRSHECKPNGHEFM 455
                  .:.:::|:|||...|..|:. ||.|:.|||||:..|.:.:.|..||||||.:..|:|..
pombe   357 ------LMMEMLWTDPQPAPGRGPSK-RGVGLQFGPDVSKRFCEANGLKAVIRSHEVRDQGYEVE 414

  Fly   456 HDNKIITIFSASNYYAIGSNKGAYIRLNNQLMPHFVQY 493
            ||...||:|||.||.....|.||.|::...:...|.|:
pombe   415 HDGYCITVFSAPNYCDSTGNLGAVIKVKEDMELDFHQF 452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rdgC	NP_536738.3	IQ	89..111	CDD:197470	2/21 (10%)
		MPP_RdgC	184..494	CDD:277364	117/312 (38%)
		EFh	616..681	CDD:238008
SPBC3F6.01c	NP_596740.1	TPR_11	4..70	CDD:290150	8/28 (29%)
		TPR repeat	5..33	CDD:276809
		TPR_11	38..104	CDD:290150	18/80 (23%)
		TPR repeat	38..68	CDD:276809	8/26 (31%)
		TPR_2	73..106	CDD:285020	10/68 (15%)
		TPR repeat	73..101	CDD:276809	9/45 (20%)
		MPP_PP5_C	152..467	CDD:277362	118/323 (37%)
		PP2Ac	184..456	CDD:197547	111/286 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910