DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rdgC and pph-5

DIOPT Version :9

Sequence 1:	NP_536738.3	Gene:	rdgC / 40224	FlyBaseID:	FBgn0265959	Length:	746	Species:	Drosophila melanogaster
Sequence 2:	NP_001367002.1	Gene:	pph-5 / 180263	WormBaseID:	WBGene00012665	Length:	496	Species:	Caenorhabditis elegans

Alignment Length:	500	Identity:	154/500 - (30%)
Similarity:	249/500 - (49%)	Gaps:	65/500 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 DDGKRRSSSVED-ASSCRSSEIERVGASMQTLGPNGQPQSSAAQTSTRASSLLQLFQRRGWCKHF 75
            :|.|.::..::| |:.....::..|.|.:.::.....|  :|.....||.:.|
Worm    23 EDEKEKAGMIKDEANQFFKDQVYDVAADLYSVAIEIHP--TAVLYGNRAQAYL------------ 73

  Fly    76 RKPLRGMSASRAEKTIRAAI---FIQKWYRRHQARREMQR-RCNWQIFQNLEYASEQDQAELYKF 136
            :|.|.|.:...|:..|  ||   :::.:|||..|...:.| :.....:|.:......|:....|
Worm    74 KKELYGSALEDADNAI--AIDPSYVKGFYRRATANMALGRFKKALTDYQAVVKVCPNDKDARAK- 135

  Fly   137 FNDLIKHMPQAAGRKNQYQGSAHVSVLDDKDDLVEEFGDIVNA----------KIELPIRKNHID 191
            |::..|.:     |:.:::  |.:|...||..:.|...  :||          ::|..|.|..:.
Worm   136 FDECSKIV-----RRQKFE--AAISTDHDKKTVAETLD--INAMAIEDSYDGPRLEDKITKEFVL 191

  Fly   192 LLIDVFRKKRGNRLHPKYVALILREAAKSLKQLPNISPVSTAVSQQVTVCGDLHGKLDDLLVVLH 256
            .||..|:.::  :||.||...:|.|....:|.||.:..::....::.|:|||:||:..||..:..
Worm   192 QLIKTFKNQQ--KLHKKYAFKMLLEFYNYVKSLPTMVEITVPTGKKFTICGDVHGQFYDLCNIFE 254

  Fly   257 KNGLPSSSNPYVFNGDFVDRGKRGLEVLLLLLSLYLAFPNAVFLNRGNHEDSVMNARYGFIREVE 321
            .||.||.:|||:|||||||||...:|.:..::...|.:||..|::|||||..|||..|||..||:
Worm   255 INGYPSETNPYLFNGDFVDRGSFSVETIFTMIGFKLLYPNHFFMSRGNHESDVMNKMYGFEGEVK 319

  Fly   322 SKYPRNHKRILAFIDEVYRWLPLGSVLNSRVLIVHGGF--SDSTSLDLIKSIDRGKYVSILRPPL 384
            :||.   :::.....|.:.||||..::|.::.:.|||.  .|..:|:.|:..||.      |.|.
Worm   320 AKYT---QQMCDMFTETFCWLPLCHLINEKIFVCHGGLFKEDGVTLEDIRKTDRN------RQPP 375

  Fly   385 TDGEPLDKTEWQQIFDIMWSDPQATMGCVPNTLRGAGVWFGPDVTDNFLQRHRLSYVIRSHECKP 449
            .:|         .:.|::|||||...|..|:. ||.|..||||||..:.:.:.:.||:||||.||
Worm   376 DEG---------IMCDLLWSDPQPINGRSPSK-RGVGCQFGPDVTSKWCETNGIEYVVRSHEVKP 430

  Fly   450 NGHEFMHDNKIITIFSASNYYAIGSNKGAYIRL-NNQLMPHFVQY 493
            .|:|..|:.:..|:|||.||....:||||:|.: .:.|.|.|..:
Worm   431 EGYEMHHNGQCFTVFSAPNYCDQMNNKGAFITITGDNLTPRFTPF 475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rdgC	NP_536738.3	IQ	89..111	CDD:197470	7/24 (29%)
		MPP_RdgC	184..494	CDD:277364	117/312 (38%)
		EFh	616..681	CDD:238008
pph-5	NP_001367002.1	PLN03088	29..>139	CDD:215568	25/126 (20%)
		TPR repeat	33..57	CDD:276809	4/23 (17%)
		TPR repeat	62..91	CDD:276809	9/42 (21%)
		TPR repeat	96..124	CDD:276809	6/27 (22%)
		MPP_PP5_C	176..490	CDD:277362	118/320 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D215218at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920