DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rdgC and pph-4.1

DIOPT Version :9

Sequence 1:	NP_536738.3	Gene:	rdgC / 40224	FlyBaseID:	FBgn0265959	Length:	746	Species:	Drosophila melanogaster
Sequence 2:	NP_499603.1	Gene:	pph-4.1 / 176657	WormBaseID:	WBGene00004085	Length:	333	Species:	Caenorhabditis elegans

Alignment Length:	319	Identity:	105/319 - (32%)
Similarity:	160/319 - (50%)	Gaps:	38/319 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   189 HIDLLIDVFRKKRGNRLHPKYVALILREAAKSLKQLPNISPVSTAVSQQVTVCGDLHGKLDDLLV 253
            ||:.|:      |...:..:.|..:..:|.:.|.:..|:.    .:...||:|||:||:..||:
Worm    35 HIEKLM------RCELIAEQDVKTLCAKAREILAEEGNVQ----VIDSPVTICGDIHGQFYDLM- 88

  Fly   254 VLHKNGLPSSSNPYVFNGDFVDRGKRGLEVLLLLLSLYLAFPNAVFLNRGNHEDSVMNARYGFIR 318
            .|.|.|.|..:..|:|.|||||||...:|..||||:|...:|:.:.|.|||||...:...|||..
Worm    89 ELFKVGGPVPNTNYLFLGDFVDRGFYSVETFLLLLALKARYPDRMMLIRGNHESRQITQVYGFYD 153

  Fly   319 EVESKYPRNHKRILAFIDEVYRWLPLGSVLNSRVLIVHGGFSDSTS-LDLIKSIDRGKYVSILRP 382
            |...||  .:..:.....||:.:|.|.:|::.:|..||||.|.|.| :|.|:.|||.:.|.
Worm   154 ECLRKY--GNASVWKHCTEVFDYLSLAAVIDGKVFCVHGGLSPSISTMDQIRVIDRKQEVP---- 212

  Fly   383 PLTDGEPLDKTEWQQIFDIMWSDPQ---ATMGCVPNTLRGAGVWFGPDVTDNFLQRHRLSYVIRS 444
              .||         .:.|::||||:   ...|..|   ||||..||.|.:..|.:.:.:..:.|:
Worm   213 --HDG---------PMCDLLWSDPEEGNVGWGLSP---RGAGYLFGADASKTFCETNGVDLICRA 263

  Fly   445 HECKPNGHEFMHDNKIITIFSASNY-YAIGSNKGAYIRLNNQLMPHFVQYISAASQTKR 502
            |:....|:::..:.|::|::||.|| |..| |..|.:.|:..|...|..: .||.|..|
Worm   264 HQLVMEGYKWHFNEKVLTVWSAPNYCYRCG-NVAAILELDENLNKEFTIF-EAAPQENR 320

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rdgC	NP_536738.3	IQ	89..111	CDD:197470
		MPP_RdgC	184..494	CDD:277364	101/309 (33%)
		EFh	616..681	CDD:238008
pph-4.1	NP_499603.1	PTZ00239	31..333	CDD:173488	105/319 (33%)
pph-4.1	NP_499603.1	MPP_PP2A_PP4_PP6	31..316	CDD:277360	102/313 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000018
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910