Protein Alignment Clc and Cltb

DIOPT Version :9

• Sequence 1: NP_001163480.1
• Gene: Clc / 40221
• FlyBaseID: FBgn0024814
• Length: 219
• Species: Drosophila melanogaster
• Sequence 2: NP_001334441.1
• Gene: Cltb / 74325
• MGIID: 1921575
• Length: 229
• Species: Mus musculus
• Alignment Length: 240
• Identity: 84/240 - (35%)
• Similarity: 128/240 - (53%)
• Gaps: 44/240 - (18%)

  Fly     2 DFGDDFAAKE-------DVDPAAEFLAREQSALGDLEAEITGGSASAPPAASTDEGLGELLGGTA 59
            ||| .|::.|       :.||||.|||:::|.:..:|.:...|:.:|...||...||
Mouse     4 DFG-FFSSSESGAPEAAEEDPAAAFLAQQESEIAGIENDPGFGAPAASQVASAQPGL-------- 59

  Fly    60 SEGDLLSAGGTGGLESST----GSFEVIGGESNEPVGISGPPPSREEPEKIRKWREEQKQRLEEK 120
                   |.|.|..:.||    ..|:...|.::....|:......:|||.|||||||||:||:|.
Mouse    60 -------ASGAGSEDMSTTVNGDVFQEANGPADGYAAIAQADRLTQEPESIRKWREEQKKRLQEL 117

  Fly   121 DIEEERKKEELRQQSKKELDDWLRQIGESISKTKLASRNAEK-----------------QAATLE 168
            |...:..::|.|:::||:|::|.::..|.:.|.|:.:|.|:|                 :|...|
Mouse   118 DAASKVTEQEWREKAKKDLEEWNQRQSEQVEKNKINNRIADKAFYQQPDADTIGYVASEEAFVKE 182

  Fly   169 NGTIEPGTEWERIAKLCDFNPKVNKAGKDVSRMRSIYLHLKQNPI 213
            :....||||||::|:|||||||.:|..|||||:||:.:.|||.|:
Mouse   183 SKEETPGTEWEKVAQLCDFNPKSSKQCKDVSRLRSVLMSLKQTPL 227

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Clc	NP_001163480.1	Clathrin_lg_ch	6..212	CDD:279433	80/233 (34%)
Cltb	NP_001334441.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..70		23/81 (28%)
		Involved in binding clathrin heavy chain	93..155		25/61 (41%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845962
Domainoid	1	1.000	133	1.000	Domainoid score	I5044
eggNOG	1	0.900	-	-		E1_KOG4031
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	134	1.000	Inparanoid score	I4563
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46883
OrthoDB	1	1.010	-	-		D1577821at2759
OrthoFinder	1	1.000	-	-		FOG0002725
OrthoInspector	1	1.000	-	-		otm42898
orthoMCL	1	0.900	-	-		OOG6_103026
Panther	1	1.100	-	-	LDO	PTHR10639
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R206
SonicParanoid	1	1.000	-	-		X3012
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.800