DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Clc and CLTB

DIOPT Version :9

Sequence 1:	NP_001163480.1	Gene:	Clc / 40221	FlyBaseID:	FBgn0024814	Length:	219	Species:	Drosophila melanogaster
Sequence 2:	NP_009028.1	Gene:	CLTB / 1212	HGNCID:	2091	Length:	229	Species:	Homo sapiens

Alignment Length:	242	Identity:	83/242 - (34%)
Similarity:	125/242 - (51%)	Gaps:	50/242 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 DDF------------AAKEDVDPAAEFLAREQSALGDLEAE----ITGGSASAPPAASTDEGLGE 53
            |||            ||:|  ||||.|||:::|.:..:|.:    ...||.:||.......|.|.
Human     3 DDFGFFSSSESGAPEAAEE--DPAAAFLAQQESEIAGIENDEGFGAPAGSHAAPAQPGPTSGAGS 65

  Fly    54 LLGGTASEGDLLSAGGTGGLESSTGSFEVIGGESNEPVGISGPPPSREEPEKIRKWREEQKQRLE 118
            ...||...||:               |:...|.::....|:......:|||.||||||||::||:
Human    66 EDMGTTVNGDV---------------FQEANGPADGYAAIAQADRLTQEPESIRKWREEQRKRLQ 115

  Fly   119 EKDIEEERKKEELRQQSKKELDDWLRQIGESISKTKLASRNAEK-----------------QAAT 166
            |.|...:..::|.|:::||:|::|.::..|.:.|.|:.:|.|:|                 :|..
Human   116 ELDAASKVTEQEWREKAKKDLEEWNQRQSEQVEKNKINNRIADKAFYQQPDADIIGYVASEEAFV 180

  Fly   167 LENGTIEPGTEWERIAKLCDFNPKVNKAGKDVSRMRSIYLHLKQNPI 213
            .|:....||||||::|:|||||||.:|..|||||:||:.:.|||.|:
Human   181 KESKEETPGTEWEKVAQLCDFNPKSSKQCKDVSRLRSVLMSLKQTPL 227

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Clc	NP_001163480.1	Clathrin_lg_ch	6..212	CDD:279433	81/238 (34%)
CLTB	NP_009028.1	Clathrin_lg_ch	1..225	CDD:395863	81/238 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..82		26/95 (27%)
		Involved in binding clathrin heavy chain	93..155		24/61 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155510
Domainoid	1	1.000	131	1.000	Domainoid score	I5149
eggNOG	1	0.900	-	-		E1_KOG4031
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	132	1.000	Inparanoid score	I4621
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46883
OrthoDB	1	1.010	-	-		D1577821at2759
OrthoFinder	1	1.000	-	-		FOG0002725
OrthoInspector	1	1.000	-	-		otm40822
orthoMCL	1	0.900	-	-		OOG6_103026
Panther	1	1.100	-	-	LDO	PTHR10639
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R206
SonicParanoid	1	1.000	-	-		X3012
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800