Protein Alignment Clc and CLTA

DIOPT Version :9

• Sequence 1: NP_001163480.1
• Gene: Clc / 40221
• FlyBaseID: FBgn0024814
• Length: 219
• Species: Drosophila melanogaster
• Sequence 2: NP_009027.1
• Gene: CLTA / 1211
• HGNCID: 2090
• Length: 248
• Species: Homo sapiens
• Alignment Length: 247
• Identity: 87/247 - (35%)
• Similarity: 120/247 - (48%)
• Gaps: 57/247 - (23%)

  Fly     4 GDDFAAKEDVDPAAEFLAREQSALGDLEAEITGGSASAPPAASTDEGLGELLGGTASEGDLLSAG 68
            |:..|...:.||||.|||:::|.:..:|               .||....|.||  :.|......
Human    20 GNGVAGAGEEDPAAAFLAQQESEIAGIE---------------NDEAFAILDGG--APGPQPHGE 67

  Fly    69 GTGGLESSTGSFEVIGG----ESNEP----VGISGPPPSREEPEKIRKWREEQKQRLEEKDIEEE 125
            ..||.::..|   |:.|    |||.|    ..||.....:.|||.||||||||.:|||..|....
Human    68 PPGGPDAVDG---VMNGEYYQESNGPTDSYAAISQVDRLQSEPESIRKWREEQMERLEALDANSR 129

  Fly   126 RKKEELRQQSKKELDDWLRQIGESISKTKLASRNAE----KQ---------------AATLENGT 171
            :::.|.::::.|||::|..:..|.:.|||..:|.|:    ||               ..:||...
Human   130 KQEAEWKEKAIKELEEWYARQDEQLQKTKANNRVADEAFYKQPFADVIGYVTNINHPCYSLEQAA 194

  Fly   172 IE----------PGTEWERIAKLCDFNPKVNKAGKDVSRMRSIYLHLKQNPI 213
            .|          |||||||:|:|||||||.:|..||||||||:.:.|||.|:
Human   195 EEAFVNDIDESSPGTEWERVARLCDFNPKSSKQAKDVSRMRSVLISLKQAPL 246

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Clc	NP_001163480.1	Clathrin_lg_ch	6..212	CDD:279433	85/242 (35%)
CLTA	NP_009027.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..92		26/91 (29%)
		Clathrin_lg_ch	20..243	CDD:395863	84/242 (35%)
		Involved in binding clathrin heavy chain	100..162		24/61 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155509
Domainoid	1	1.000	131	1.000	Domainoid score	I5149
eggNOG	1	0.900	-	-		E1_KOG4031
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1384
Inparanoid	1	1.050	132	1.000	Inparanoid score	I4621
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46883
OrthoDB	1	1.010	-	-		D1577821at2759
OrthoFinder	1	1.000	-	-		FOG0002725
OrthoInspector	1	1.000	-	-		otm40822
orthoMCL	1	0.900	-	-		OOG6_103026
Panther	1	1.100	-	-	O	PTHR10639
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R206
SonicParanoid	1	1.000	-	-		X3012
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800