Protein Alignment Clc and Cltb

DIOPT Version :10

• Sequence 1: NP_524178.2
• Gene: Clc / 40221
• FlyBaseID: FBgn0024814
• Length: 219
• Species: Drosophila melanogaster
• Sequence 2: NP_446287.1
• Gene: Cltb / 116561
• RGDID: 621353
• Length: 229
• Species: Rattus norvegicus
• Alignment Length: 240
• Identity: 84/240 - (35%)
• Similarity: 128/240 - (53%)
• Gaps: 44/240 - (18%)

  Fly     2 DFGDDFAAKE-------DVDPAAEFLAREQSALGDLEAEITGGSASAPPAASTDEGLGELLG--- 56
            ||| .|::.|       :.||||.|||:::|.:..:|.:...|:.:|...||...||....|
  Rat     4 DFG-FFSSSESGAPEAAEEDPAAAFLAQQESEIAGIENDSGFGAPAASQVASAQPGLASGGGSED 67

  Fly    57 -GTASEGDLLSAGGTGGLESSTGSFEVIGGESNEPVGISGPPPSREEPEKIRKWREEQKQRLEEK 120
             ||...||:               |:...|.::....|:......:|||.|||||||||:||:|.
  Rat    68 MGTTVNGDV---------------FQEANGPADGYAAIAQADRLTQEPESIRKWREEQKKRLQEL 117

  Fly   121 DIEEERKKEELRQQSKKELDDWLRQIGESISKTKLASRNAEK-----------------QAATLE 168
            |...:..::|.|:::||:|::|.::..|.:.|.|:.:|.|:|                 :|...|
  Rat   118 DAASKVTEQEWREKAKKDLEEWNQRQSEQVEKNKINNRIADKAFYQQPDADTIGYVASEEAFVKE 182

  Fly   169 NGTIEPGTEWERIAKLCDFNPKVNKAGKDVSRMRSIYLHLKQNPI 213
            :....||||||::|:|||||||.:|..|||||:||:.:.|||.|:
  Rat   183 SKEETPGTEWEKVAQLCDFNPKSSKQCKDVSRLRSVLMSLKQTPL 227

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Clc	NP_524178.2	Clathrin_lg_ch	11..211	CDD:460056	78/227 (34%)
Cltb	NP_446287.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..80		26/91 (29%)
		Clathrin_lg_ch	4..225	CDD:460056	82/236 (35%)
		Involved in binding clathrin heavy chain	93..155		25/61 (41%)