DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Clc and cltb

DIOPT Version :9

Sequence 1:	NP_001163480.1	Gene:	Clc / 40221	FlyBaseID:	FBgn0024814	Length:	219	Species:	Drosophila melanogaster
Sequence 2:	XP_005168279.1	Gene:	cltb / 100329879	ZFINID:	ZDB-GENE-101005-2	Length:	226	Species:	Danio rerio

Alignment Length:	239	Identity:	89/239 - (37%)
Similarity:	126/239 - (52%)	Gaps:	45/239 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DFGDDFAAKE-----DVDPAAEFLAREQSALGDLEAEITGGS-----ASAPPAASTDEGLGELLG 56
            |||  |:|.:     :.||||.|||::::.:..:|.:.||.|     .:||....|..| |:..|
Zfish     4 DFG--FSAFDNGVHTEEDPAAAFLAQQENEIAVIENDSTGFSLPEDGGAAPADTYTMSG-GDFGG 65

  Fly    57 GTASEGDLLSAGGTGGLESSTGSFEVIGGESNEPVGISGPPPSREEPEKIRKWREEQKQRLEEKD 121
            .:|..||:..  .|.|:   |.|:..|.     .|.|     .|:|||.:||||||||.||||.|
Zfish    66 SSAVNGDMFQ--DTNGM---TDSYSAIA-----QVDI-----QRQEPESLRKWREEQKTRLEELD 115

  Fly   122 IEEERKKEELRQQSKKELDDWLRQIGESISKTKLASRNAEKQAATLENGTI-------------- 172
            ...:..:...|:::||||:||.....|.:.|.|:.:|.|:|......|..:
Zfish   116 SASKAAEAVWREKAKKELEDWHIHQTEQMEKNKVNNRIADKAFYKQPNSDVIGFVASEEAFLKEC 180

  Fly   173 ---EPGTEWERIAKLCDFNPKVNKAGKDVSRMRSIYLHLKQNPI 213
               .||||||::|:|||||||.::..||||||||:.:.|||.|:
Zfish   181 EDDSPGTEWEKVARLCDFNPKTSRQTKDVSRMRSVLISLKQTPL 224

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Clc	NP_001163480.1	Clathrin_lg_ch	6..212	CDD:279433	85/232 (37%)
cltb	XP_005168279.1	Clathrin_lg_ch	1..223	CDD:279433	88/236 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590673
Domainoid	1	1.000	129	1.000	Domainoid score	I5216
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	131	1.000	Inparanoid score	I4611
OMA	1	1.010	-	-		QHG46883
OrthoDB	1	1.010	-	-		D1577821at2759
OrthoFinder	1	1.000	-	-		FOG0002725
OrthoInspector	1	1.000	-	-		otm25180
orthoMCL	1	0.900	-	-		OOG6_103026
Panther	1	1.100	-	-	LDO	PTHR10639
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3012
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.910