DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17233 and PRR12

DIOPT Version :9

Sequence 1:	NP_730500.1	Gene:	CG17233 / 40220	FlyBaseID:	FBgn0036958	Length:	1465	Species:	Drosophila melanogaster
Sequence 2:	NP_065770.1	Gene:	PRR12 / 57479	HGNCID:	29217	Length:	2036	Species:	Homo sapiens

Alignment Length:	1870	Identity:	310/1870 - (16%)
Similarity:	527/1870 - (28%)	Gaps:	729/1870 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 GSSGGTAEDFQHPHLATITAASIASFNAAAASGGSFVPPS---PIG-----SYNP--VFQQIY-- 73
            |..||.|:|..               .|.:.|||...|||   |.|     ||:|  :..|:|
Human   460 GFGGGQAQDLS---------------KAPSYSGGPPQPPSGPPPPGLATCQSYSPDQLQGQLYGV 509

  Fly    74 ----HHAAAASVQPKPAHYASSAVSTPH----------------------------RQLQLPSSL 106
                :...||..|..|....|.:.||.|                            |.||.|.:.
Human   510 QGEPYPGPAAHSQGLPTASPSLSYSTGHSPALSGHGGGWGPSSLGGGGEASPSHIIRPLQSPPAT 574

  Fly   107 ------------DKQLSSFQNQA-------AVSAAAAAVVNNVASNYYGENSSSS-----GASPS 147
                        .|.|||....|       |.|.||.      |..|.|:...|.     |..|:
Human   575 GRPPGVGSPGAPGKYLSSVLASAPFLAPPGAGSYAAG------AGGYKGKGDGSELLAGPGGPPA 633

  Fly   148 PTT----------VALTSTSLTWNTPNMISNTFLA-----------------MQQQQAQQQQQQA 185
            ..|          :...|...|.....::.....|                 ...:.|::..|:.
Human   634 ERTEDEEFLIQHLLQAPSPPRTSGADGLVGEDGAADASKGLGGSGGAGGPPGTPYELAKEDPQRY 698

  Fly   186 QQQQQ-QAQQQQQQAQQQQLNLVADKVQIKQE-----------------------KQLKAYNDSI 226
            ..|.. :......:.....|.|...:::.|::                       |:|.|:
Human   699 HLQSVIRTSASLDEGATAALELGLGRLKEKKKGPERGGETPEGLATSVVHYGAGAKELGAF---- 759

  Fly   227 YLIQLQQQQQQQQTAAQQQQQQLH--------------------QQLQQEIAEADTEPDTYYTID 271
                ||:........||..|...|                    |.|...::.|.:...:...:.
Human   760 ----LQKSPPPPPPTAQSTQPTPHGLLLEAGGPDLPLVLPPPPPQLLPSVLSHAPSPSPSASKVG 820

  Fly   272 GRKVKVTRKDGQPYRATIVDQQDASPVPLAVPVPAGSYPVQYASPALSSADGSPITNLHAVDVVS 336
            ...::...:||.|       |....|.|...|:|. .......|..|..|..||  .|...:.:.
Human   821 VHLLEPATRDGAP-------QPPPPPPPPPPPMPL-QLEAHLRSHGLEPAAPSP--RLRPEESLD 875

  Fly   337 TPQAQVIVYKTASPV--------------QRRQEAGAGSS----AAATPTTVAYSSVIQSTLQQQ 383
            .|.|...:.....|:              :.:..|||..|    ....|..|..:|:.......|
Human   876 PPGAMQELLGALEPLPPAPGDTGVGPPNSEGKDPAGAYRSPSPQGTKAPRFVPLTSICFPDSLLQ 940

  Fly   384 QQQQNLCWTKLEDNGAGQEDIKNVLQLQVKQEHRQLDFASEASSVDAG----GGGENLVFNLPPG 444
            .::::...|..|..|.|..|                |:.......|.|    |.|.      |||
Human   941 DEERSFFPTMEEMFGGGAAD----------------DYGKAGPPEDEGDPKAGAGP------PPG 983

  Fly   445 LEIKQTFYP--------------------------ASVVDGEQLQLQEHNQNQ------------ 471
            ......:.|                          .|.|:.|.|.|.:...:|
Human   984 PPAYDPYGPYCPGRASGAGPETPGLGLDPNKPPELPSTVNAEPLGLIQSGPHQAAPPPPPPPPPP 1048

  Fly   472 ----SQSSG------------------------RRQ------------------------HVVAN 484
                |:..|                        ||:                        .|.|:
Human  1049 PAPASEPKGGLTSPIFCSTKPKKLLKTSSFHLLRRRDPPFQTPKKLYAQEYEFEADEDKADVPAD 1113

  Fly   485 MIMSPS-----AGNLASQIQVVPKEEV-----------------KP-------PPKP-------- 512
            :.::|.     ..:..|:..:.|..::                 ||       ||:|
Human  1114 IRLNPRRLPDLVSSCRSRPALSPLGDIDFCPPNPGPDGPRRRGRKPTKAKRDGPPRPRGRPRIRP 1178

  Fly   513 ------------------AKTPRKR----------------QPKKTL-----IP----------- 527
                              ||.||.|                :|.|.|     :|
Human  1179 LEVPTTAGPASASTPTDGAKKPRGRGRGRGRKAEEAGGTRLEPLKPLKIKLSVPKAGEGLGTSSG 1243

  Fly   528 ---SSSDYGNVRSPQEPQHHQLQQQQQQQQQHNQQQQQQNTYYDF--NSKWNAPLKTENNAASVS 587
               |.:|:.::.|....:..:.:.::.:::|...:.....::.||  :.|.:.||........:|
Human  1244 DAISGTDHNSLDSSLTREKIEAKIKEVEEKQPEMKSGFMASFLDFLKSGKRHPPLYQAGLTPPLS 1308

  Fly   588 PAATINIPTYPQQSQQQQHQQQQAQQQQQQHLPQPAHLQSSQAQSHLTQLAQYYPAFPQPIASQY 652
            |..::. |:.|.:..|                |||...                ||.|.|..|..
Human  1309 PPKSVP-PSVPARGLQ----------------PQPPAT----------------PAVPHPPPSGA 1340

  Fly   653 ----------------TACMQQQQQQQQQQQQQQQQQAAYTQQQHQQAYTQQQQQQAQQQRQEKS 701
                            ..|....::..::.::..:...:::..                  :|.|
Human  1341 FGLGGALEAAESEGLGLGCPSPCKRLDEELKRNLETLPSFSSD------------------EEDS 1387

  Fly   702 EATQQQEEEANAAAAAA---AAAAASNKVIVPNIEEELDFLADATATPKQGYANSL-SSNGRGTN 762
            .|..:..:|:.::|.:|   ...|.......|:...    ||.|.|.|.......| |:|..||.
Human  1388 VAKNRDLQESISSAISALDDPPLAGPKDTSTPDGPP----LAPAAAVPGPPPLPGLPSANSNGTP 1448

  Fly   763 SSTNNTNFGIRNPNKTPSPEPTNCPPNSHASNNGHGHSAVTPVAPSSTGASASTAYSPVAPKPVS 827
            ............|...|:|:|...||.....          |..||.....|.|..|| .|.|:
Human  1449 EPPLLEEKPPPTPPPAPTPQPQPPPPPPPPQ----------PALPSPPPLVAPTPSSP-PPPPL- 1501

  Fly   828 VGTLIGEKKTQFMDSYLKFLQGERDDDPPPVVKPS-------------RKLNYPRAP-------- 871
                                     ..|||...||             .....|.||
Human  1502 -------------------------PPPPPPAMPSPPPPPPPAAAPLAAPPEEPAAPSPEDPELP 1541

  Fly   872 -------YKRKGKGSGSGDEPTTSQATQSAGDAVQAVDGLAGLVGDDGHRIKILSQTQILPKKRP 929
                   .|::...:..|:  |..:|.:|.|:.:........:..:|...:|:..||   .::.|
Human  1542 DTRPLHLAKKQETAAVCGE--TDEEAGESGGEGIFRERDEFVIRAEDIPSLKLALQT---GREPP 1601

  Fly   930 HAQMVAAAAAAESAPSSSVIQQPGDQTS-----FRPYAQQQQQAQQQQQQSMSGQHFVQQHCAQL 989
            ....|..|...:..|.....|:....||     |.....:.|:...:..::::.:.:|:. ||
Human  1602 PIWRVQKALLQKFTPEIKDGQRQFCATSNYLGYFGDAKNRYQRLYVKFLENVNKKDYVRV-CA-- 1663

  Fly   990 TAGAGQDPLSVPPRREQCSRKAKQSSMHAMLMNSSSVVGDGGVVGEP------------DEFTDS 1042
                 :.|...||...:.|.:||            :.|..||....|            .|.|.|
Human  1664 -----RKPWHRPPVPVRRSGQAK------------NPVSAGGSSAPPPKAPAPPPKPETPEKTTS 1711

  Fly  1043 DTDPVWTPQ------------------EEDSDDGK-GYGKRKLARRSKGTPRKNTYDHSSGLQQQ 1088
            :..|..||:                  |::.:..| ..|:|.| |..:.|..:.|....|....|
Human  1712 EKPPEQTPETAMPEPPAPEKPSLLRPVEKEKEKEKVTRGERPL-RGERATSGRQTRPERSLATGQ 1775

  Fly  1089 PQQQQQHHQQLQQMQVNQQHHQQQQQVQQMAGGESTYNSQQNMSGVADVGYASAS-SGPAANSEN 1152
            |...:....:..:::......::::.::: |||.:|       :|....|.:|.| |.|.|.||
Human  1776 PATSRLPKARPTKVKAEPPPKKRKKWLKE-AGGNAT-------AGGGPPGSSSDSESSPGAPSE- 1831

  Fly  1153 FKTGDFIVLRSDLVNDWPTIWQVDSKCILQKYEPFRQNGKTFYRNMSKYASWNLETKKLYLKAPV 1217
                                   |.:.:     |.|.                |:|:.:
Human  1832 -----------------------DERAV-----PGRL----------------LKTRAM------ 1846

  Fly  1218 RIQLHSHTETIVEFMRSELLADDTEQFIEKIMEDYLSYRDNFEIYIQTMISQALDPSFFSEITRE 1282
                                                  |:.:..|::.::|.||||.....:...
Human  1847 --------------------------------------REMYRSYVEMLVSTALDPDMIQALEDT 1873

  Fly  1283 KDDYFLGSVRVVDNIMENCKRKLLAITPWTRSTISSIETWPKCHVFSEWEQNNLTQKNCAGCHQP 1347
            .|:.:|..:|.:|.::...|:|:|.....:.:...::.|:|:..|    ||:.      .|..:.
Human  1874 HDELYLPPMRKIDGLLNEHKKKVLKRLSLSPALQDALHTFPQLQV----EQSG------EGSPEE 1928

  Fly  1348 GIAVRFLLFGEPYNPNTMQTIPVDPRIVYEKDIVLCRICAARAD------LFHKIAHEKFNLFIN 1406
            | |||....|||||..|:..:        ::.:|..:......:      |:|.:.|.|::.|:.
Human  1929 G-AVRLRPAGEPYNRKTLSKL--------KRSVVRAQEFKVELEKSGYYTLYHSLHHYKYHTFLR 1984

  Fly  1407 CSQRVTEQQQQFPGKTSTEILNDLLAEHNWIDELFRNMRNCWAEVESLER 1456
            |..:....:.........|::...:....|:::||.:..:..|:.::..|
Human  1985 CRDQTLAIEGGAEDLGQEEVVQQCMRNQPWLEQLFDSFSDLLAQAQAHSR 2034

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17233	NP_730500.1	DUF4211	1234..1372	CDD:290637	30/137 (22%)
PRR12	NP_065770.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	210..283
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	331..587		31/141 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	649..697		4/47 (9%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	758..850		18/107 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	859..878		5/20 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	886..925		5/38 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	952..1068		21/137 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1120..1260		19/139 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1294..1347		15/85 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1376..1573		47/257 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1668..1840		41/221 (19%)
		DUF4211	1840..1945	CDD:316448	31/175 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	47	1.000	Domainoid score	I12045
eggNOG	1	0.900	-	-		E1_KOG4805
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5203
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.930