DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17233 and Prr12

DIOPT Version :9

Sequence 1:	NP_730500.1	Gene:	CG17233 / 40220	FlyBaseID:	FBgn0036958	Length:	1465	Species:	Drosophila melanogaster
Sequence 2:	NP_778187.2	Gene:	Prr12 / 233210	MGIID:	2679002	Length:	2035	Species:	Mus musculus

Alignment Length:	1904	Identity:	303/1904 - (15%)
Similarity:	514/1904 - (26%)	Gaps:	795/1904 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 GSSGGTAEDFQHPHLATITAASIASFNAAAASGGSFVPPS---PIG-----SYNP--VFQQIY-- 73
            |..||.|:|..               ...:.|||...|||   |.|     ||:|  :..|:|
Mouse   457 GFGGGQAQDLS---------------KGPSYSGGPPQPPSGPPPPGLATCQSYSPDQLQGQLYGV 506

  Fly    74 ----HHAAAASVQPKPAHYASSAVSTPH----------------------------RQLQLPSSL 106
                :...||..|..|....|.:.||.|                            |.||.|.:.
Mouse   507 QSEPYPGPAAHSQGLPTASPSLSYSTGHSPALSGHGGGWGPSSLGGGGEASPSHIIRPLQSPPAT 571

  Fly   107 ------------DKQLSS------FQNQAAVSAAAAAVVNNVASNYYGENSSS------------ 141
                        .|.|||      |......|:.||.     |..|.|:...|
Mouse   572 GRPPGVGSPGAPGKYLSSVLASAPFLAPPGASSYAAG-----AGGYKGKGDGSELLAGPGGSAAE 631

  Fly   142 ---------------------SGA-------SPSPTTVALTSTSLTWNTPNMISNTFLAMQQQQA 178
                                 |||       .|:.....|..:......|    .|...:.::..
Mouse   632 RTEDEEFLIQHLLQAPSPPRTSGADGLVGEDGPADAAKGLGGSGGAGGAP----GTPYELAKEDP 692

  Fly   179 QQQQ-QQAQQQQQQAQQQQQQAQQQQLNLVADKVQIKQE-------------------KQLKAYN 223
            |:.. |...:......:....|.:..|..:.||.:..:.                   |:|.|:
Mouse   693 QRYHLQSVIRTSASLDEGATAALELGLGRMKDKKKGPERGGETPEGLATSVVHYGAGAKELGAF- 756

  Fly   224 DSIYLIQLQQQQQQQQTAAQQQQQQLH--------------------QQLQQEIAEADTEPDTYY 268
                   ||:.......:||..|...|                    |.|...::.|.:...:..
Mouse   757 -------LQKSPPPPPPSAQATQPAPHGLLLEAGGPDLPMVLPPPPPQLLPSVLSHAPSPSPSAP 814

  Fly   269 TIDGRKVKVTRKDGQPYRATIVDQQDASPVPLAVPV----------------------------P 305
            .:....::...:||.|        |...|.|..:|:                            |
Mouse   815 KVGVHLLEPATRDGAP--------QPPPPPPPPMPLQLEAHLRGHGLEPTAPSPRLRPEESLEPP 871

  Fly   306 AGSYPVQYASPALSSADGSPITNLHAVDVVSTPQAQ----VIVYKTASPVQRRQEAGAGSSAAAT 366
            .....:..|...|.|..|.|        .|..|.::    ...|::.||        .|:.|
Mouse   872 GAMQELLGALEPLPSGPGDP--------GVGPPNSEGKDPAGAYRSPSP--------QGTKA--- 917

  Fly   367 PTTVAYSSVIQSTLQQQQQQQNLCWTKLEDNGAGQEDIKNVLQLQVKQEHRQLDFASEASSVDAG 431
            |..|..:|:.......|.::::...|..|..|.|..|                |:.....:.|.|
Mouse   918 PRFVPLTSICFPDSLLQDEERSFFPTMEEMFGGGAAD----------------DYGKAGQTEDDG 966

  Fly   432 ----------------------GG----------GENLVFNLPPGLEIKQTFYPASVVDGEQLQL 464
                                  ||          |..|..|.||.|        .|.|:.|.|.|
Mouse   967 DPKTGAGPPPGPTAYDPYGPYCGGRASGTGPETPGLGLDHNKPPEL--------PSTVNAEPLGL 1023

  Fly   465 QEHNQNQSQSSGRRQHVVANMIMSPSAGNLASQIQVVPKEEVKPPPKPAKTPR---------KRQ 520
            .:...:||               :|            |.....|||.|...|:         ..:
Mouse  1024 IQSGPHQS---------------AP------------PPPPPPPPPPPVSEPKGGLTSPIFCSTK 1061

  Fly   521 PKKTLIPSSSDYGNVRSPQEPQHHQLQQQQQQQQQHNQQQQQQNTYYDFNS---KWNAPLKTENN 582
            |||.|..||             .|.|:::....|...:...|:   |:|.:   |.:.|.....|
Mouse  1062 PKKLLKTSS-------------FHLLRRRDPPFQTPKKLYAQE---YEFEADEDKADVPADIRLN 1110

  Fly   583 -------------AASVSPAATINI------PTYPQQSQQQQHQQQQAQQQQQQHLPQPAHLQSS 628
                         ..::||...|:.      |..|::..::..:.::....:.:..|:...|:.
Mouse  1111 PRRLPDLVSSCRSRPALSPLGDIDFCPPNPGPDGPRRRGRKPTKAKRDGPPRPRGRPRIRPLEG- 1174

  Fly   629 QAQSHLTQLAQYYPAFPQPIASQYTACMQQQQQQQQQQQQQQQQQAAYTQQ--QHQQAYTQQQQQ 691
                         ||...|                          |:.|..  :..:...:.:.:
Mouse  1175 -------------PAMAGP--------------------------ASITTDGAKKPRGRGRGRGR 1200

  Fly   692 QAQQQRQEKSEATQQQEEEANAAAAAAAAAAASNKVI--------------------VPNIEEE- 735
            :|::....:.|..:..:.:.:...|.....|.||.||                    :..:||:
Mouse  1201 KAEEMGGTRLEPLKPLKIKLSVPKAGEGLGAPSNDVISGVDHNSLDSNLTREKIEAKIKEVEEKQ 1265

  Fly   736 -----------LDFLADATATP---KQGYANSLSSNGRGTNSSTNNTNFGIRNPNKTPSPEPTN- 785
                       ||||......|   :.|....||.                  |...|:..||.
Mouse  1266 PEMKSGFMASFLDFLKSGKRHPPLYQAGLTPPLSP------------------PKSVPASVPTRG 1312

  Fly   786 -CPPNSHASNNGHGHSAVTPVAPSSTGASASTAYSP----VAPKPVSVGTLIGEKKTQFMDSYLK 845
             .||........|    ..|..|...|.:...|.|.    ..|.|..   .:.|:..:.:::...
Mouse  1313 LQPPPPTVPTVPH----PAPSGPFGLGGALEAAESEGLGLGCPSPCK---RLDEELKRNLETLPS 1370

  Fly   846 FLQGERDD------------------DPPPVVKPSRKLNYPRAPYKRKGKGSGSGDEPTTSQATQ 892
            |...|.|.                  |.||:..| :..:.|..|....|. :.||..|..|..:.
Mouse  1371 FSSDEEDSVAKNRDLQESISSAISALDDPPLTGP-KDTSTPEEPPLDTGP-TASGPPPLPSLPSS 1433

  Fly   893 SAGDAVQAVDGLAGLVGDDGHRIKILSQ------------------------TQILPKKRPHAQM 933
            ::....:.               .:|.:                        ...||...|....
Mouse  1434 NSSGTPEP---------------PLLEEKPPPTPPPAPTPQPAPPPPPPPPPVPALPSPTPLVTP 1483

  Fly   934 VAAAAAAESAP-------SSSVIQQPGDQTSFRPYAQQQQQAQQQQQQSMSGQHFVQQHCAQLTA 991
            ||::......|       .|.....|...|:..|.|..::.                      .|
Mouse  1484 VASSPPPPPPPPPPPPALPSPPPPPPPAPTTVPPVAPPEEP----------------------PA 1526

  Fly   992 GAGQDPLSVPPRREQCSRKAKQSSMHAMLMNSSSVVGDGGVVGEPDEF---------------TD 1041
            .:.:||.....|....::|.:.:::.......:...|..|:..|.|||               |.
Mouse  1527 PSPEDPEPPDARPLHLAKKQETAAVCGETDEEAGESGGEGIFRERDEFVIRAEDIPSLKLALQTG 1591

  Fly  1042 SDTDPVW----------TPQEEDSD--------------DGKG-----YGK-----------RKL 1066
            .:..|:|          ||:.:|..              |.|.     |.|           |..
Mouse  1592 REPPPIWRVQKALLQKFTPEIKDGQRQFCATSNYLGYFGDAKNRYQRLYVKFLENVNKKDYVRVC 1656

  Fly  1067 ARR--------------SKG----------------------TPRKNTYDHSSGLQQQP------ 1089
            ||:              :||                      ||.|.|.:.......:|
Mouse  1657 ARKPWHRPPLPVRRSGQTKGPTPVGGNSAPPSKVQAPPPKPETPEKMTSEKPPEPAPEPAVPEPP 1721

  Fly  1090 -------------QQQQQHHQQLQQMQVNQ-------QHHQQQQQVQQMAGGESTYN--SQQNMS 1132
                         :::::..::.::.:|.:       ...:|.:..:.:|.|:||.:  .:...|
Mouse  1722 APEKPSPPRPVEKEKEKEKEKEKEKERVTRPLRSERATSGRQMRTDRSLATGQSTTSRLPKARPS 1786

  Fly  1133 GV--------------ADVGYASASSGPAANSENFKTGDFIVLRSDLVNDWPTIWQVDSKCILQK 1183
            .|              ..||.|||..||..:|.:.::.             |.....|.:.:
Mouse  1787 KVKAEPPPKKRKKWLKEAVGNASAGDGPGGSSSDSESS-------------PGAPSEDERAV--- 1835

  Fly  1184 YEPFRQNGKTFYRNMSKYASWNLETKKLYLKAPVRIQLHSHTETIVEFMRSELLADDTEQFIEKI 1248
              |.|.                |:|:.:
Mouse  1836 --PGRL----------------LKTRAM------------------------------------- 1845

  Fly  1249 MEDYLSYRDNFEIYIQTMISQALDPSFFSEITREKDDYFLGSVRVVDNIMENCKRKLLAITPWTR 1313
                   |:.:..|::.::|.||||.....:....|:.:|..:|.:|.::...|:|:|.....:.
Mouse  1846 -------REMYRSYVEMLVSTALDPDMIQALEDTHDELYLPPMRKIDGLLNEHKKKVLKRLSLSP 1903

  Fly  1314 STISSIETWPKCHVFSEWEQNNLTQKNCAGCHQPGIAVRFLLFGEPYNPNTMQTIPVDPRIVYEK 1378
            :...::.|:|:..|    ||..      .|..:.| |||....|||||..|:..:        ::
Mouse  1904 ALQDALHTFPQLQV----EQTG------EGSPEEG-AVRLRPAGEPYNRKTLSKL--------KR 1949

  Fly  1379 DIVLCRICAARAD------LFHKIAHEKFNLFINCSQRVTEQQQQFPGKTSTEILNDLLAEHNWI 1437
            .:|..:......:      |:|.:.|.|::.|:.|..:....:.........|::...:....|:
Mouse  1950 SVVRAQEFKVELEKSGYYTLYHSLHHYKYHTFLRCRDQTLAIEGGAEDLGQEEVVQQCMRNQPWL 2014

  Fly  1438 DELFRNMRNCWAEVESLER 1456
            ::||.:..:..|:.::..|
Mouse  2015 EQLFDSFSDLLAQAQAHSR 2033

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17233	NP_730500.1	DUF4211	1234..1372	CDD:290637	30/137 (22%)
Prr12	NP_778187.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	210..280
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	292..311
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	329..584		30/141 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	645..685		7/43 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	755..844		17/104 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	851..870		0/18 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	879..920		13/59 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	946..1061		29/165 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1112..1244		20/171 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1288..1355		17/88 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1367..1567		32/238 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1662..1839		26/194 (13%)
		DUF4211	1827..1950	CDD:290637	35/206 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	47	1.000	Domainoid score	I11939
eggNOG	1	0.900	-	-		E1_KOG4805
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	98	1.000	Inparanoid score	I5003
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5203
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.980