DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Su(var)3-3 and Kdm1a

DIOPT Version :9

Sequence 1:	NP_649194.1	Gene:	Su(var)3-3 / 40217	FlyBaseID:	FBgn0260397	Length:	890	Species:	Drosophila melanogaster
Sequence 2:	XP_006539392.1	Gene:	Kdm1a / 99982	MGIID:	1196256	Length:	877	Species:	Mus musculus

Alignment Length:	864	Identity:	447/864 - (51%)
Similarity:	575/864 - (66%)	Gaps:	76/864 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 MTEPIEYVTLISDDSDGEPTPKRNV---NHPPSALSAPNPGQKQKHPDEDSNDAPATSDE----- 69
            :|.|.:..|    .:.||.||::..   ..||..|:.| ||.........:....||..|
Mouse    45 LTGPTDMAT----GAAGERTPRKKEPPRASPPGGLAEP-PGSAGPQAGPTAGPGSATPMETGIAE 104

  Fly    70 ----RRTSRRNRPKVDYSNRPSGSGDTASNDKSGSASMGPNNQQAERRSQ-----SQTRKSEANA 125
                ||||||.|.||:|........:.:.::   ..|....|.:||:..:     .|....|.|.
Mouse   105 TPEGRRTSRRKRAKVEYREMDESLANLSEDE---YYSEEERNAKAEKEKKLPPPPPQAPPEEENE 166

  Fly   126 TSSSVSGPSAGNSRPSQNGDSKDRDAGTPTVLSGQEGAVFQSRLPFNKMTPNEEACFPDISRSGI 190
            :........||..:...:|...|..|      ||.|||.||||||.::||..|.||||||.....
Mouse   167 SEPEEPSGQAGGLQDDSSGGYGDGQA------SGVEGAAFQSRLPHDRMTSQEAACFPDIISGPQ 225

  Fly   191 LGHRVFLNIRNSLLHMWVDNPKIQLSFEIALKNLPPPFDSEPSLVRRVHSFLERHGFINFGIFKR 255
            ...:|||.|||..|.:|:|||||||:||..|:.|..|::|:..||.||||:|||||.|||||:||
Mouse   226 QTQKVFLFIRNRTLQLWLDNPKIQLTFEATLQQLEAPYNSDTVLVHRVHSYLERHGLINFGIYKR 290

  Fly   256 LKPIPAKKLGKVIVIGAGISGLAVAHQLQQFGMDVIVLEARDRVGGRISTFRKNSYIADVGAMVV 320
            :||:|.||.||||:||:|:||||.|.|||.|||||.:||||||||||::||||.:|:||:|||||
Mouse   291 IKPLPIKKTGKVIIIGSGVSGLAAARQLQSFGMDVTLLEARDRVGGRVATFRKGNYVADLGAMVV 355

  Fly   321 TGVYGNPMTILSKQIGMDLVPIQQTCPLYGPDGK----PVPKEKDDVIEREFNRLLESASYLSHR 381
            ||:.||||.::|||:.|:|..|:|.||||..:|:    .||||||:::|:|||||||:.|||||:
Mouse   356 TGLGGNPMAVVSKQVNMELAKIKQKCPLYEANGQADTVKVPKEKDEMVEQEFNRLLEATSYLSHQ 420

  Fly   382 LDFNYAGDCPVSLGDALEWIISMQEMQVMHKRGQHMQEIIATQTKIIEQRRRLKTLRDTIGKLKN 446
            ||||...:.|||||.|||.:|.:||..|..::.:|.::|:.||.::.|...::..|::.|.:|..
Mouse   421 LDFNVLNNKPVSLGQALEVVIQLQEKHVKDEQIEHWKKIVKTQEELKELLNKMVNLKEKIKELHQ 485

  Fly   447 EHLAMINQRKP---------KGTDGDLKYCYQEFN-IRNTQIKMEETISTFHDLHAEEKQMLAKL 501
            ::......:.|         |....||....:|:: :..||.|:||                 ||
Mouse   486 QYKEASEVKPPRDITAEFLVKSKHRDLTALCKEYDELAETQGKLEE-----------------KL 533

  Fly   502 HELEQNRPSDVYLSSRDRLILDWHFANLEFANATRLNNLSLKHWDQDDDFEFIGHHTTVRNGYSC 566
            .|||.|.|||||||||||.|||||||||||||||.|:.||||||||||||||.|.|.||||||||
Mouse   534 QELEANPPSDVYLSSRDRQILDWHFANLEFANATPLSTLSLKHWDQDDDFEFTGSHLTVRNGYSC 598

  Fly   567 VPVALTENLDIRVNSAVKEIKYGTKGVEVVAENLKTSNSQMTYKADLVVCTLTLGVLKVAVAHKE 631
            |||||.|.|||::|:||::::|...|.||:|.|.::::....||.|.|:|||.|||||
Mouse   599 VPVALAEGLDIKLNTAVRQVRYTASGCEVIAVNTRSTSQTFIYKCDAVLCTLPLGVLK------- 656

  Fly   632 SQQSNTVKFDPPLPDWKQQAIKRLGFGNLNKVVLCFDRIFWDPNANLFGHVGSTTASRGEMFLFW 696
             ||...|:|.||||:||..|::|:||||||||||||||:||||:.|||||||||||||||:||||
Mouse   657 -QQPPAVQFVPPLPEWKTSAVQRMGFGNLNKVVLCFDRVFWDPSVNLFGHVGSTTASRGELFLFW 720

  Fly   697 SISSSPVLLALVAGMAANLVESVTDDIIIGRCMSVLKNIFGNTSVPQPKETVVTRWRSDPWARGS 761
            ::..:|:|||||||.||.::|:::||:|:|||:::||.|||:::|||||||||:|||:|||||||
Mouse   721 NLYKAPILLALVAGEAAGIMENISDDVIVGRCLAILKGIFGSSAVPQPKETVVSRWRADPWARGS 785

  Fly   762 YSYVSVGSSGSDYDLLAAPVIP-PSSKDA-EGLPRLFFAGEHTIRNYPATVHGAYLSGLREAGRI 824
            ||||:.||||:||||:|.|:.| ||...| :.:|||||||||||||||||||||.||||||||||
Mouse   786 YSYVAAGSSGNDYDLMAQPITPGPSIPGAPQPIPRLFFAGEHTIRNYPATVHGALLSGLREAGRI 850

  Fly   825 ADYYLG----YPEGTPPDI 839
            ||.:||    .|....|.:
Mouse   851 ADQFLGAMYTLPRQATPGV 869

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(var)3-3	NP_649194.1	SWIRM	165..250	CDD:282311	48/84 (57%)
		NAD_binding_8	269..327	CDD:290186	41/57 (72%)
		Amino_oxidase	274..824	CDD:279874	330/565 (58%)
Kdm1a	XP_006539392.1	PHA03378	<39..>99	CDD:223065	15/58 (26%)
Kdm1a	XP_006539392.1	PLN02328	204..850	CDD:215187	392/670 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848881
Domainoid	1	1.000	670	1.000	Domainoid score	I150
eggNOG	1	0.900	-	-		E1_COG1231
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H32240
Inparanoid	1	1.050	837	1.000	Inparanoid score	I446
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52579
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001117
OrthoInspector	1	1.000	-	-		oto93270
orthoMCL	1	0.900	-	-		OOG6_103427
Panther	1	1.100	-	-	LDO	PTHR10742
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2622
SonicParanoid	1	1.000	-	-		X2101
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790