DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Su(var)3-3 and PAO3

DIOPT Version :9

Sequence 1:	NP_649194.1	Gene:	Su(var)3-3 / 40217	FlyBaseID:	FBgn0260397	Length:	890	Species:	Drosophila melanogaster
Sequence 2:	NP_191464.1	Gene:	PAO3 / 825074	AraportID:	AT3G59050	Length:	488	Species:	Arabidopsis thaliana

Alignment Length:	577	Identity:	169/577 - (29%)
Similarity:	245/577 - (42%)	Gaps:	146/577 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   262 KKLGKVIVIGAGISGLAVAHQLQQFGMDVIVLEARDRVGGRISTFRKNSYIADVGAMVVTGV-YG 325
            |:...|||||.|::|::.|..||.....|:|||:|||:|||:.|.....:..|:||..:.|| ..
plant    26 KRSPSVIVIGGGMAGISAARTLQDASFQVVVLESRDRIGGRVHTDYSFGFPVDLGASWLHGVCKE 90

  Fly   326 NPMTILSKQIGMDLVPIQQTCPLYGPDGKPVPKEKDDVIEREFNRLLESASYLSHRLDFNYAGDC 390
            ||:..:..::|:         |||...|.              |.:|......|:.| |:.||:
plant    91 NPLAAVIGRLGL---------PLYRTSGD--------------NSVLYDHDLESYAL-FDKAGN- 130

  Fly   391 PVSLGDALEWIISMQEMQVMHKRGQHMQEIIATQTKIIEQRRRLKTLRDTIGKLKNEHLAMINQR 455
                                    |..||::   ||:.|   ..:.:.:.|.|:::|.
plant   131 ------------------------QVSQELV---TKVGE---NFEHILEEICKVRDEQ------- 158

  Fly   456 KPKGTDGDLKYCYQEFNI---RNTQIKMEETISTFHDLHAEEKQMLAKLHELEQNRPSDVYLSSR 517
                 |.|:... |.|:|   ||.::::|                     .|..|
plant   159 -----DEDMSIA-QAFSIVFKRNPELRLE---------------------GLAHN---------- 186

  Fly   518 DRLILDWHFANLEFANATRLNNLSLKHWDQDDDFEFI--GHHTTVRNGYSCVPVALTENLDIRVN 580
               :|.|:...:|...|.....:|.|.|||:   |.:  ||...|| ||..|...|::.||||::
plant   187 ---VLQWYLCRMEGWFAADAETISAKCWDQE---ELLPGGHGLMVR-GYRPVINTLSKGLDIRLS 244

  Fly   581 SAVKEIKYGTKGVEVVAENLKTSNSQMTYKADLVVCTLTLGVLKVAVAHKESQQSNTVKFDPPLP 645
            ..:.:|.....||:|      |:....|:.||..|..|.|||||          |..:.|:|.||
plant   245 HRITKISRRYSGVKV------TTEKGDTFVADAAVIALPLGVLK----------SGMITFEPKLP 293

  Fly   646 DWKQQAIKRLGFGNLNKVVLCFDRIFWDPNANLFGHVGSTTASRGEMFLFWSISSSPVLLALVAG 710
            .|||:||..||.|..||::|.||.:|| ||....|.|..|:............:|.|||:.:.||
plant   294 QWKQEAINDLGVGIENKIILNFDNVFW-PNVEFLGVVAETSYGCSYFLNLHKATSHPVLVYMPAG 357

  Fly   711 MAANLVESVTDDIIIGRCMSVLKNIFGNTSVPQPKETVVTRWRSDPWARGSYSYVSVGSSGSDYD 775
            ..|..:|..:|:.......|.|:.|..:.|  .|...:|:||.||..:.|||||..|......|:
plant   358 QLARDIEKKSDEAAANFAFSQLQKILPDAS--SPINYLVSRWGSDINSLGSYSYDIVNKPHDLYE 420

  Fly   776 LLAAPVIPPSSKDAEGLPRLFFAGEHTIRNYPATVHGAYLSGLREAG----RIADYY 828
            .|..|           |..||||||.|..:||.:|||||.:|:..|.    |:.:.|
plant   421 RLRVP-----------LDNLFFAGEATSSSYPGSVHGAYSTGVLAAEDCRMRVLERY 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(var)3-3	NP_649194.1	SWIRM	165..250	CDD:282311
		NAD_binding_8	269..327	CDD:290186	24/58 (41%)
		Amino_oxidase	274..824	CDD:279874	160/559 (29%)
PAO3	NP_191464.1	PLN02268	29..463	CDD:177909	167/569 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1231
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1034142at2759
OrthoFinder	1	1.000	-	-		FOG0001117
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10742
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.920