Protein Alignment Su(var)3-3 and kdm1a

DIOPT Version :10

• Sequence 1: NP_649194.1
• Gene: Su(var)3-3 / 40217
• FlyBaseID: FBgn0260397
• Length: 890
• Species: Drosophila melanogaster
• Sequence 2: NP_001229924.1
• Gene: kdm1a / 558450
• ZFINID: ZDB-GENE-030131-7828
• Length: 833
• Species: Danio rerio
• Alignment Length: 825
• Identity: 434/825 - (52%)
• Similarity: 570/825 - (69%)
• Gaps: 85/825 - (10%)

  Fly    24 SDDSDGEPTPKRNVNHPPSALSAPNPGQKQKHPDEDSNDAPATSDERRTSRRNRPKVDYSNRPSG 88
            |.:..|.|.|     ||      |.||    ..|:||      ::.||||||.|.||:|...
Zfish    54 SGEPGGPPLP-----HP------PGPG----GIDQDS------AEGRRTSRRKRAKVEYREM--- 94

  Fly    89 SGDTASNDKSGSASMGPNNQQAERRSQSQTRKSEANATSSSVSGPSAGNSRPSQNGDSKDRDAGT 153
                   |:| .|::..:...:|     :.|.::|......|..|.|   .|.:  :..|.:...
Zfish    95 -------DES-LANLSEDEYYSE-----EERNAKAEKERKQVIPPPA---PPIE--EENDSEPEE 141

  Fly   154 PTVLSGQEGAVFQSRLPFNKMTPNEEACFPDISRSGILGHRVFLNIRNSLLHMWVDNPKIQLSFE 218
            |:.::|.|||.||||||.::||..|.||||||........:|||.|||..|.:|:||||:||:||
Zfish   142 PSGINGVEGAAFQSRLPHDRMTSQEAACFPDIINGPQHTQKVFLYIRNRTLQLWLDNPKVQLTFE 206

  Fly   219 IALKNLPPPFDSEPSLVRRVHSFLERHGFINFGIFKRLKPIPAKKLGKVIVIGAGISGLAVAHQL 283
            ..::.|..|::|:..||.|:||:|||||||||||:||:||:|.||.|||||||||:||||.|.||
Zfish   207 ATVQQLEAPYNSDAVLVHRIHSYLERHGFINFGIYKRVKPLPTKKTGKVIVIGAGVSGLAAARQL 271

  Fly   284 QQFGMDVIVLEARDRVGGRISTFRKNSYIADVGAMVVTGVYGNPMTILSKQIGMDLVPIQQTCPL 348
            |.|||||.|||:|||||||::||||.:|:||:|||||||:.||||.::|||:.|:|..|:|.|||
Zfish   272 QSFGMDVTVLESRDRVGGRVATFRKGNYVADLGAMVVTGLGGNPMAVVSKQVNMELAKIKQKCPL 336

  Fly   349 YGPDGK------PVPKEKDDVIEREFNRLLESASYLSHRLDFNYAGDCPVSLGDALEWIISMQEM 407
            |..:|:      .||||||:::|:|||||||:.|||||:||||:..:.|||||.|||.:|.:||.
Zfish   337 YEANGQAGERCTSVPKEKDEMVEQEFNRLLEATSYLSHQLDFNFLNNKPVSLGQALEVVIQLQEK 401

  Fly   408 QVMHKRGQHMQEIIATQTKIIEQRRRLKTLRDTIGKLKNEHLAMINQRKP---------KGTDGD 463
            .|..::.:|.::|:.||.::.:...::.|.::.:.:|..::......:.|         |....|
Zfish   402 HVKDEQIEHWKKIVKTQEELKDLLNKMVTTKEKVKELHQQYKEASEVKPPRDITAEFLVKSKHRD 466

  Fly   464 LKYCYQEFN-IRNTQIKMEETISTFHDLHAEEKQMLAKLHELEQNRPSDVYLSSRDRLILDWHFA 527
            |....:|:: :...|:|:||                 :|.|||.|.|||||||||||.|||||||
Zfish   467 LTALCKEYDELVEMQVKLEE-----------------RLQELEANPPSDVYLSSRDRQILDWHFA 514

  Fly   528 NLEFANATRLNNLSLKHWDQDDDFEFIGHHTTVRNGYSCVPVALTENLDIRVNSAVKEIKYGTKG 592
            ||||||||.|:.||||||||||||||.|.|.|||||||||||||.|.|||::|:||::::|.:.|
Zfish   515 NLEFANATPLSTLSLKHWDQDDDFEFTGSHLTVRNGYSCVPVALAEGLDIKLNTAVRQVRYTSSG 579

  Fly   593 VEVVAENLKTSNSQMTYKADLVVCTLTLGVLKVAVAHKESQQSNTVKFDPPLPDWKQQAIKRLGF 657
            .||:|.|.:::.....||.|.|:|||.|||:|        ||...|:|.||||:||..||:|:||
Zfish   580 CEVIAVNTRSTTQTFIYKCDAVLCTLPLGVMK--------QQPPAVQFVPPLPEWKTAAIQRMGF 636

  Fly   658 GNLNKVVLCFDRIFWDPNANLFGHVGSTTASRGEMFLFWSISSSPVLLALVAGMAANLVESVTDD 722
            ||||||||||||:||||:.|||||||||||||||:||||::..:|:||||:||.||.::|:::||
Zfish   637 GNLNKVVLCFDRVFWDPSVNLFGHVGSTTASRGELFLFWNLYKAPILLALMAGEAAGIMENISDD 701

  Fly   723 IIIGRCMSVLKNIFGNTSVPQPKETVVTRWRSDPWARGSYSYVSVGSSGSDYDLLAAPVIP-PSS 786
            :|:|||:::||.|||:::|||||||||:|||:|||||||||||:.||||:||||:|.|:.| |:.
Zfish   702 VIVGRCLAILKGIFGSSAVPQPKETVVSRWRADPWARGSYSYVAAGSSGNDYDLMAQPITPGPAI 766

  Fly   787 KDA-EGLPRLFFAGEHTIRNYPATVHGAYLSGLREAGRIADYYLG 830
            ..| :.:|||||||||||||||||||||.||||||||||||.:||
Zfish   767 PGASQPVPRLFFAGEHTIRNYPATVHGALLSGLREAGRIADQFLG 811

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Su(var)3-3	NP_649194.1	PLN03000	74..>827	CDD:178578	415/770 (54%)
kdm1a	NP_001229924.1	PLN02328	157..805	CDD:215187	386/672 (57%)
		COG1340	<375..>493	CDD:440951	34/134 (25%)