DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Su(var)3-3 and SMOX

DIOPT Version :9

Sequence 1:	NP_649194.1	Gene:	Su(var)3-3 / 40217	FlyBaseID:	FBgn0260397	Length:	890	Species:	Drosophila melanogaster
Sequence 2:	NP_001257620.1	Gene:	SMOX / 54498	HGNCID:	15862	Length:	585	Species:	Homo sapiens

Alignment Length:	688	Identity:	168/688 - (24%)
Similarity:	252/688 - (36%)	Gaps:	223/688 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   251 GIFKRLKPIPAKKLGKVIVIGAGISGLAVAHQLQQFGM-DVIVLEARDRVGGRISTFRKNSYIAD 314
            |:.:|.:|       :|:|||||::|||.|..|.:.|. ||.||||...:|||:.:.:......:
Human    18 GLRRRGQP-------RVVVIGAGLAGLAAAKALLEQGFTDVTVLEASSHIGGRVQSVKLGHATFE 75

  Fly   315 VGAMVVTGVYGNPMTILSKQIGMDLVPIQQT---------CPLYGPD---------GKPVPKEKD 361
            :||..:.|.:|||:..|::..|:    :::|         ..||..:         |:.:||
Human    76 LGATWIHGSHGNPIYHLAEANGL----LEETTDGERSVGRISLYSKNGVACYLTNHGRRIPK--- 133

  Fly   362 DVIEREFNRLLESASYLSHRLDFNYAGDCPVSLGDALEWIISMQEMQVMHKRGQHMQEIIATQTK 426
            ||:| ||:.|......|:...   :..|.||:                     ...|..:...|:
Human   134 DVVE-EFSDLYNEVYNLTQEF---FRHDKPVN---------------------AESQNSVGVFTR 173

  Fly   427 IIEQRRRLKTLRDTIGKLKNEHLAMINQRKPKGTDGDLKYCYQEFNIRNTQIKMEETISTFHDLH 491
             .|.|.|::...|.....|...||||.|                      .:|:|...|:.|.:
Human   174 -EEVRNRIRNDPDDPEATKRLKLAMIQQ----------------------YLKVESCESSSHSM- 214

  Fly   492 AEEKQMLAKLHELEQNRPSDVYLSSRDRLILDWHFANLEFANATRLNNLSLKHWDQDDDFEFIGH 556
                              .:|.||                         :...|.     |..|.
Human   215 ------------------DEVSLS-------------------------AFGEWT-----EIPGA 231

  Fly   557 HTTVRNGYSCVPVALTENLDIRVNSAVKEIK-----------------------------YGTKG 592
            |..:.:|:..|...|.|.:...|....|.::                             .|.:|
Human   232 HHIIPSGFMRVVELLAEGIPAHVIQLGKPVRCIHWDQASARPRGPEIEPRGEGDHNHDTGEGGQG 296

  Fly   593 VEVVAENLKTSNSQMT----------YKADLVVCTLTLGVLKVAVAHKESQQSNTVKFDPPLPDW 647
            .|.........:.|.:          ..||.|:.|::|||||         :..|..|.|.||..
Human   297 GEEPRGGRWDEDEQWSVVVECEDCELIPADHVIVTVSLGVLK---------RQYTSFFRPGLPTE 352

  Fly   648 KQQAIKRLGFGNLNKVVLCFDRIFWDPNANLFGHVGSTTASR---------------GEMFLFWS 697
            |..||.|||.|..:|:.|.|:..||.|..|....|....|..               |...|:..
Human   353 KVAAIHRLGIGTTDKIFLEFEEPFWGPECNSLQFVWEDEAESHTLTYPPELWYRKICGFDVLYPP 417

  Fly   698 ISSSPVLLALVAGMAANLVESVTDDIIIGRCMSVLKNIFGNTSVPQPKETVVTRWRSDPWARGSY 762
            .....||...:.|..|.::|...|:.:...|..:|:...||.::|:|:..:.:.|.|:|:.||||
Human   418 ERYGHVLSGWICGEEALVMEKCDDEAVAEICTEMLRQFTGNPNIPKPRRILRSAWGSNPYFRGSY 482

  Fly   763 SYVSVGSSGSDYDLLAAPV-IPPSSKDAEGLP----------------------------RLFFA 798
            ||..|||||:|.:.||.|: ...|||.|.|..                            ::.|:
Human   483 SYTQVGSSGADVEKLAKPLPYTESSKTAHGSSTKQQPGHLFSSKCPEQPLDANRGAVKPMQVLFS 547

  Fly   799 GEHTIRNYPATVHGAYLSGLREAGRIADYYLG-YPEGT 835
            ||.|.|.|.:|.|||.|||.|||.|:.:.|.. :.:||
Human   548 GEATHRKYYSTTHGALLSGQREAARLIEMYRDLFQQGT 585

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(var)3-3	NP_649194.1	SWIRM	165..250	CDD:282311
		NAD_binding_8	269..327	CDD:290186	24/58 (41%)
		Amino_oxidase	274..824	CDD:279874	155/651 (24%)
SMOX	NP_001257620.1	NAD_binding_8	<45..88	CDD:290186	14/42 (33%)
SMOX	NP_001257620.1	PLN02568	50..578	CDD:215308	150/640 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2622
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940