Protein Alignment Su(var)3-3 and MAOA

DIOPT Version :10

• Sequence 1: NP_649194.1
• Gene: Su(var)3-3 / 40217
• FlyBaseID: FBgn0260397
• Length: 890
• Species: Drosophila melanogaster
• Sequence 2: NP_000231.1
• Gene: MAOA / 4128
• HGNCID: 6833
• Length: 527
• Species: Homo sapiens
• Alignment Length: 644
• Identity: 132/644 - (20%)
• Similarity: 223/644 - (34%)
• Gaps: 191/644 - (29%)

  Fly   267 VIVIGAGISGLAVAHQLQQFGMDVIVLEARDRVGGRISTFRKNSYI--ADVGAMVVTGVYGNPMT 329
            |:|||.|||||:.|..|.::|:.|:|||||||||||..|.| |.::  .|||...| |...|.:.
Human    16 VVVIGGGISGLSAAKLLTEYGVSVLVLEARDRVGGRTYTIR-NEHVDYVDVGGAYV-GPTQNRIL 78

  Fly   330 ILSKQIGMDLVPIQ-----------QTCPLYGPDGKPVPKEKDDVIEREFNRLLESASYLSHRLD 383
            .|||::|::...:.           :|.|..|    ..|...:.:...::|.|..:...:...:
Human    79 RLSKELGIETYKVNVSERLVQYVKGKTYPFRG----AFPPVWNPIAYLDYNNLWRTIDNMGKEI- 138

  Fly   384 FNYAGDCPVSLGDALEWIISMQEMQVMHKRGQHMQEIIATQTKIIEQRRRLKTLRDTIGKLKNEH 448
               ..|.|.....|.:|    .:|               |..::|::....||.|
Human   139 ---PTDAPWEAQHADKW----DKM---------------TMKELIDKICWTKTAR---------- 171

  Fly   449 LAMINQRKPKGTDGDLKYCYQEFNIRNTQIKMEETISTFHDLHAEEKQMLAKLHELEQNRPSDVY 513
                            ::.|...||..|        |..|::.|
Human   172 ----------------RFAYLFVNINVT--------SEPHEVSA--------------------- 191

  Fly   514 LSSRDRLILDWHFANLEFANATRLNNLSLKHWDQDDDFEFIGHHTTVRNGYSCVPVALTENL--D 576
                  |...|:..  :....||:  .|:.:..|:.  :|:|       |...|...:.:.|  .
Human   192 ------LWFLWYVK--QCGGTTRI--FSVTNGGQER--KFVG-------GSGQVSERIMDLLGDQ 237

  Fly   577 IRVNSAVKEIKYGTKGVEVVAENLKTSNSQMTYKADLVVCTLTLGVLKVAVAHKESQQSNTVKFD 641
            :::|..|..:...:.  .::.|.|...:.:..|..:.:..|||.                .:.|.
Human   238 VKLNHPVTHVDQSSD--NIIIETLNHEHYECKYVINAIPPTLTA----------------KIHFR 284

  Fly   642 PPLPDWKQQAIKRLGFGNLNKVVLCFDRIFW------------DPNANLFGHVGSTTASRGEMFL 694
            |.||..:.|.|:||..|.:.|.::.:...||            |.:|.:...:..|...
Human   285 PELPAERNQLIQRLPMGAVIKCMMYYKEAFWKKKDYCGCMIIEDEDAPISITLDDTKPD------ 343

  Fly   695 FWSISSSPVLLALVAGMAANLVESVTDDIIIGRCMSVLKNIFGNTSVPQPKETVVTRWRSDPWAR 759
                .|.|.::..:....|:.:..:..:|...:...:...:.|:.....|.......|..:.::.
Human   344 ----GSLPAIMGFILARKADRLAKLHKEIRKKKICELYAKVLGSQEALHPVHYEEKNWCEEQYSG 404

  Fly   760 GSY-SYVSVGSSGSDYDLLAAPVIPPSSKDAEGLPRLFFAGEHTIRNYPATVHGAYLSGLREAGR 823
            |.| :|...|.......::..||           .|:||||..|     ||....|:.|..|||.
Human   405 GCYTAYFPPGIMTQYGRVIRQPV-----------GRIFFAGTET-----ATKWSGYMEGAVEAGE 453

  Fly   824 IA--DYYLGYPEGTPPDIGYSVAEA--------------ANLVSVGNVVKLRDLSPNLS 866
            .|  :...|..:.|..||.....|:              .||.||..::|:...|.:::
Human   454 RAAREVLNGLGKVTEKDIWVQEPESKDVPAVEITHTFWERNLPSVSGLLKIIGFSTSVT 512

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Su(var)3-3	NP_649194.1	PLN03000	74..>827	CDD:178578	121/589 (21%)
MAOA	NP_000231.1	YobN	11..464	CDD:440844	122/594 (21%)
		Interaction with membrane phospholipid headgroups. /evidence=ECO:0000305	520..522