DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Su(var)3-3 and CG10561

DIOPT Version :9

Sequence 1:	NP_649194.1	Gene:	Su(var)3-3 / 40217	FlyBaseID:	FBgn0260397	Length:	890	Species:	Drosophila melanogaster
Sequence 2:	NP_476608.1	Gene:	CG10561 / 35189	FlyBaseID:	FBgn0002036	Length:	504	Species:	Drosophila melanogaster

Alignment Length:	595	Identity:	143/595 - (24%)
Similarity:	227/595 - (38%)	Gaps:	157/595 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   261 AKKLGKVIVIGAGISGLAVAHQLQQFGM-DVIVLEARDRVGGRISTFRKNSYIADVGA--MVVTG 322
            |::..:::|:|||::||:.|..|...|. ..::|||.||.||||:|.|......::||  :.:.|
  Fly    35 ARQNTQIVVVGAGLAGLSAAQHLLSHGFRRTVILEATDRYGGRINTQRFGDTYCELGAKWVKIDG 99

  Fly   323 VYGNPMTILSKQIGMDLVPIQQTCPLYGPDGKPVPKEKDDVIEREFNRLLESASYLSHRLDFNYA 387
            ...:...:|....|:.....|.....|..||..:.....::|:..|.:|..... :|.|:  ...
  Fly   100 SQDSMYELLRNTEGLGKQIKQPDRATYLQDGSRINPAMVELIDTLFRQLCRGFK-VSERV--KTG 161

  Fly   388 GDCPVSLGDALEWIISMQEMQVMHKRGQHMQEIIATQTKIIEQRRRLKTLRDTIGKLKNEHLAMI 452
            ||.. ||.:.:.:..:..: :::....||.::.:|.       |...::|....|.:
  Fly   162 GDLH-SLDNVMNYFRTESD-RIIGVSFQHPKDQLAA-------REIFQSLFKEFGSI-------- 209

  Fly   453 NQRKPKGTDGDLKYCYQEFNIRNTQIKMEETISTFHDLHAEEKQMLAKLHELEQNRPSDVYLSSR 517
                       |..|.:..||.:                      :.|....::.||  :|:
  Fly   210 -----------LGCCLEYVNIEH----------------------ITKCPVQQEQRP--LYV--- 236

  Fly   518 DRLILDWHFANLEFANATRLNNLSLKHWDQDDDFEFIGHHTTVRNGYSCVPVALTENLD---IRV 579
                            .|.|:|:.       ||                    |.:|:|   ::.
  Fly   237 ----------------PTGLDNVV-------DD--------------------LIQNMDKAQLQT 258

  Fly   580 NSAVKEIKY---GTKGVEVVAENLKTSNSQMTYKADLVVCTLTLGVLKVAVAHKESQQSNTVKFD 641
            ...|.:|::   ..|.|..:..:|        |.||.::|||.|||||....         |.|.
  Fly   259 GKPVGQIQWTPAPMKSVGCLDGSL--------YNADHIICTLPLGVLKSFAG---------VLFR 306

  Fly   642 PPLPDWKQQAIKRLGFGNLNKVVLCFDRIF--W-----DPNANLFGHVGSTTASRGEMFLFWS-- 697
            |.||..|..||:.|||||..|:.|.:.:..  |     .|...|..........|.     |:
  Fly   307 PTLPLDKMLAIRNLGFGNPLKIYLSYKKPIGRWLKGSLRPLGTLLNPSVEQQPERN-----WTQQ 366

  Fly   698 ---ISSSP----VLLALVAGMAANLVESVTDDIIIGRCMSVLKNIFGNTSVPQPKETVVTRWRSD 755
               ||..|    ||...|.|.....:|.:.|:.::.:...:|:....:..||.|:|.:.:.|.:.
  Fly   367 VVEISQVPSSQHVLEVHVGGGYYEEIEKLPDEELLEQITGLLRRCVSSHLVPYPQELLRSNWSTS 431

  Fly   756 PWARGSYSYVSVGSSGSDYDLLAAPVIPPSSKDAEGLPRLFFAGEHT-IRNYPATVHGAYLSGLR 819
            ....|...|.|..||..|...||||:       .|..|.|.|||:.| :|.: .|:..|..||:|
  Fly   432 ACYLGGRPYFSTNSSARDVQRLAAPL-------GEKSPGLLFAGDATSLRGF-GTIDAARSSGIR 488

  Fly   820 EAGRIADYYL 829
            ||.||.||||
  Fly   489 EAQRIIDYYL 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(var)3-3	NP_649194.1	SWIRM	165..250	CDD:282311
		NAD_binding_8	269..327	CDD:290186	23/60 (38%)
		Amino_oxidase	274..824	CDD:279874	132/575 (23%)
CG10561	NP_476608.1	NAD_binding_8	43..109	CDD:290186	23/65 (35%)
CG10561	NP_476608.1	Amino_oxidase	48..494	CDD:279874	133/576 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45452811
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46708
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10742
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.940