DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Su(var)3-3 and Kdm1b

DIOPT Version :9

Sequence 1:	NP_649194.1	Gene:	Su(var)3-3 / 40217	FlyBaseID:	FBgn0260397	Length:	890	Species:	Drosophila melanogaster
Sequence 2:	NP_001100813.1	Gene:	Kdm1b / 306819	RGDID:	1310701	Length:	824	Species:	Rattus norvegicus

Alignment Length:	752	Identity:	207/752 - (27%)
Similarity:	325/752 - (43%)	Gaps:	196/752 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   114 SQSQTRKSEANATSSSVSGPSAGNSRPSQNGDSKDRDAGTPTVLSGQEGAVFQSRLPFNKMTPNE 178
            |.|.|....|..|:::....|.|...||:        |...:::.|. ...||   ||.:  |||
  Rat   231 SPSCTSTHRAAVTATATGSASPGEMEPSK--------AAPASLVLGM-NRYFQ---PFYQ--PNE 281

  Fly   179 ---EAC-------------FPDISRSGILGHRVFLNIRNSLLHMWVDNPKIQLSFEIALKNLPPP 227
               ..|             ||:.||...:    :|.:||.:|.:|..|.|..|:.:..:     |
  Rat   282 CGKALCVRPDVMELDELYEFPEYSRDPTM----YLALRNLILALWYTNCKEALTPQKCI-----P 337

  Fly   228 FDSEPSLVR--------RVHSFLERHGFINFGIF-----KRLKPIPAKKLGK-VIVIGAGISGLA 278
            ......|||        |:..|:.|.|.||.|:.     :.|  :|.....| |:|:|||.:|||
  Rat   338 HVIVRGLVRIRCVQEVERILYFMTRKGLINTGVLTVGAGQHL--LPKHYHNKSVLVVGAGPAGLA 400

  Fly   279 VAHQLQQFGMDVIVLEARDRVGGRI---STFRKNSYIADVGAMVVTGVYGNPMTILSKQIGMDLV 340
            .|.||..|||.|.||||:||:|||:   .:|:  ..:...|..:|.|...||:.::.:|:|:.:.
  Rat   401 AARQLHNFGMKVTVLEAKDRIGGRVWDDKSFK--GVVVGRGPQIVNGCINNPVALMCEQLGIRMH 463

  Fly   341 PIQQTCPLYGPDGKPVPKEKDDVIEREFNRLLESASYLSHRLDFNYAGDCPVSLGDALEWIISMQ 405
            .:.:.|.|....|:......|..::..||.||:..|                      ||
  Rat   464 KLGERCDLIQEGGRITDPTIDKRMDFHFNALLDVVS----------------------EW----- 501

  Fly   406 EMQVMHKRGQHMQEIIATQTKIIEQRRRLKTLRDTIGKLKNEHLAMINQRKPKGTDGDLKYCYQE 470
                                      |:.|||...:               |.|.
  Rat   502 --------------------------RKDKTLLQDV---------------PLGE---------- 515

  Fly   471 FNIRNTQIKMEETISTFHDLHAEEKQMLAKLHELEQNRPSDVYLSSRDRLILDWHFANLEFANAT 535
                    |:||....|                   .:.|.:..|..:..:|.:|.:|||:|..:
  Rat   516 --------KIEEIYRAF-------------------VKESGIQFSELEGQVLQFHLSNLEYACGS 553

  Fly   536 RLNNLSLKHWDQDDDF-EFIGHHTTVRNGYSCVPVALTENLDIRVNSAVKEIKYGTKGVEVVAEN 599
            .|:.:|.:.||.::.| :|.|.||.:..|||.:...|.|.||||:.|.|:.|.|....|:|
  Rat   554 SLHQVSARSWDHNEFFAQFAGDHTLLTPGYSTIVEKLAEGLDIRLKSPVQSIDYTGDEVQV---- 614

  Fly   600 LKTSNSQMTYKADLVVCTLTLGVLKVAVAHKESQQSNTVKFDPPLPDWKQQAIKRLGFGNLNKVV 664
              |:...:.:.|..|:.|:.|.:|          |...::|:|||.:.|.:||..||.|.:.|:.
  Rat   615 --TTTDGVVHSAQKVLVTVPLAML----------QRGAIQFNPPLSEKKMKAINSLGAGIIEKIA 667

  Fly   665 LCFDRIFWD---PNANLFGHVGSTTASRGEMFLFWSIS-SSPVLLALVAGMAANLVESVTDDIII 725
            |.|...|||   ..|:.||||..:.:.||...:|:.:. ...||::::.|.|...:.::.|..::
  Rat   668 LQFPYRFWDSKVQGADFFGHVPPSASQRGLFAVFYDMGPQQSVLMSVITGEAVASLRTMDDKQVL 732

  Fly   726 GRCMSVLKNIFGNTSVPQPKETVVTRWRSDPWARGSYSYVSVGSSGSDYDLLAAPVIPPSSKDAE 790
            .:|:.||:.:|....:|.|.:..||||.::||.:.:||:|....||..||::|        ::.:
  Rat   733 QQCLGVLRELFKEQEIPDPTKYFVTRWNTEPWIQMAYSFVKTFGSGEAYDIIA--------EEIQ 789

  Fly   791 GLPRLFFAGEHTIRNYPATVHGAYLSGLREAGRIADY 827
            |  .::||||.|.|::|.||.||||||:|||.:||.:
  Rat   790 G--TVYFAGEATNRHFPQTVTGAYLSGVREASKIAAF 824

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(var)3-3	NP_649194.1	SWIRM	165..250	CDD:282311	29/108 (27%)
		NAD_binding_8	269..327	CDD:290186	27/60 (45%)
		Amino_oxidase	274..824	CDD:279874	155/557 (28%)
Kdm1b	NP_001100813.1	zf-CW	138..191	CDD:284831
		SWIRM	285..367	CDD:282311	21/90 (23%)
		Amino_oxidase	403..821	CDD:279874	151/550 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1231
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1034142at2759
OrthoFinder	1	1.000	-	-		FOG0001117
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820