Protein Alignment Su(var)3-3 and Kdm1b

DIOPT Version :10

• Sequence 1: NP_649194.1
• Gene: Su(var)3-3 / 40217
• FlyBaseID: FBgn0260397
• Length: 890
• Species: Drosophila melanogaster
• Sequence 2: NP_001100813.1
• Gene: Kdm1b / 306819
• RGDID: 1310701
• Length: 824
• Species: Rattus norvegicus
• Alignment Length: 752
• Identity: 207/752 - (27%)
• Similarity: 325/752 - (43%)
• Gaps: 196/752 - (26%)

  Fly   114 SQSQTRKSEANATSSSVSGPSAGNSRPSQNGDSKDRDAGTPTVLSGQEGAVFQSRLPFNKMTPNE 178
            |.|.|....|..|:::....|.|...||:        |...:::.|. ...||   ||.:  |||
  Rat   231 SPSCTSTHRAAVTATATGSASPGEMEPSK--------AAPASLVLGM-NRYFQ---PFYQ--PNE 281

  Fly   179 ---EAC-------------FPDISRSGILGHRVFLNIRNSLLHMWVDNPKIQLSFEIALKNLPPP 227
               ..|             ||:.||...:    :|.:||.:|.:|..|.|..|:.:..:     |
  Rat   282 CGKALCVRPDVMELDELYEFPEYSRDPTM----YLALRNLILALWYTNCKEALTPQKCI-----P 337

  Fly   228 FDSEPSLVR--------RVHSFLERHGFINFGIF-----KRLKPIPAKKLGK-VIVIGAGISGLA 278
            ......|||        |:..|:.|.|.||.|:.     :.|  :|.....| |:|:|||.:|||
  Rat   338 HVIVRGLVRIRCVQEVERILYFMTRKGLINTGVLTVGAGQHL--LPKHYHNKSVLVVGAGPAGLA 400

  Fly   279 VAHQLQQFGMDVIVLEARDRVGGRI---STFRKNSYIADVGAMVVTGVYGNPMTILSKQIGMDLV 340
            .|.||..|||.|.||||:||:|||:   .:|:  ..:...|..:|.|...||:.::.:|:|:.:.
  Rat   401 AARQLHNFGMKVTVLEAKDRIGGRVWDDKSFK--GVVVGRGPQIVNGCINNPVALMCEQLGIRMH 463

  Fly   341 PIQQTCPLYGPDGKPVPKEKDDVIEREFNRLLESASYLSHRLDFNYAGDCPVSLGDALEWIISMQ 405
            .:.:.|.|....|:......|..::..||.||:..|                      ||
  Rat   464 KLGERCDLIQEGGRITDPTIDKRMDFHFNALLDVVS----------------------EW----- 501

  Fly   406 EMQVMHKRGQHMQEIIATQTKIIEQRRRLKTLRDTIGKLKNEHLAMINQRKPKGTDGDLKYCYQE 470
                                      |:.|||...:               |.|.
  Rat   502 --------------------------RKDKTLLQDV---------------PLGE---------- 515

  Fly   471 FNIRNTQIKMEETISTFHDLHAEEKQMLAKLHELEQNRPSDVYLSSRDRLILDWHFANLEFANAT 535
                    |:||....|                   .:.|.:..|..:..:|.:|.:|||:|..:
  Rat   516 --------KIEEIYRAF-------------------VKESGIQFSELEGQVLQFHLSNLEYACGS 553

  Fly   536 RLNNLSLKHWDQDDDF-EFIGHHTTVRNGYSCVPVALTENLDIRVNSAVKEIKYGTKGVEVVAEN 599
            .|:.:|.:.||.::.| :|.|.||.:..|||.:...|.|.||||:.|.|:.|.|....|:|
  Rat   554 SLHQVSARSWDHNEFFAQFAGDHTLLTPGYSTIVEKLAEGLDIRLKSPVQSIDYTGDEVQV---- 614

  Fly   600 LKTSNSQMTYKADLVVCTLTLGVLKVAVAHKESQQSNTVKFDPPLPDWKQQAIKRLGFGNLNKVV 664
              |:...:.:.|..|:.|:.|.:|          |...::|:|||.:.|.:||..||.|.:.|:.
  Rat   615 --TTTDGVVHSAQKVLVTVPLAML----------QRGAIQFNPPLSEKKMKAINSLGAGIIEKIA 667

  Fly   665 LCFDRIFWD---PNANLFGHVGSTTASRGEMFLFWSIS-SSPVLLALVAGMAANLVESVTDDIII 725
            |.|...|||   ..|:.||||..:.:.||...:|:.:. ...||::::.|.|...:.::.|..::
  Rat   668 LQFPYRFWDSKVQGADFFGHVPPSASQRGLFAVFYDMGPQQSVLMSVITGEAVASLRTMDDKQVL 732

  Fly   726 GRCMSVLKNIFGNTSVPQPKETVVTRWRSDPWARGSYSYVSVGSSGSDYDLLAAPVIPPSSKDAE 790
            .:|:.||:.:|....:|.|.:..||||.::||.:.:||:|....||..||::|        ::.:
  Rat   733 QQCLGVLRELFKEQEIPDPTKYFVTRWNTEPWIQMAYSFVKTFGSGEAYDIIA--------EEIQ 789

  Fly   791 GLPRLFFAGEHTIRNYPATVHGAYLSGLREAGRIADY 827
            |  .::||||.|.|::|.||.||||||:|||.:||.:
  Rat   790 G--TVYFAGEATNRHFPQTVTGAYLSGVREASKIAAF 824

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Su(var)3-3	NP_649194.1	PLN03000	74..>827	CDD:178578	207/750 (28%)
Kdm1b	NP_001100813.1	zf-CW	138..191	CDD:462181
		PLN02328	<306..821	CDD:215187	183/658 (28%)