DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Su(var)3-3 and Lao1

DIOPT Version :9

Sequence 1:	NP_649194.1	Gene:	Su(var)3-3 / 40217	FlyBaseID:	FBgn0260397	Length:	890	Species:	Drosophila melanogaster
Sequence 2:	NP_001100152.1	Gene:	Lao1 / 298483	RGDID:	1310787	Length:	519	Species:	Rattus norvegicus

Alignment Length:	689	Identity:	142/689 - (20%)
Similarity:	243/689 - (35%)	Gaps:	240/689 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   187 RSGILGHRVFLNIRNSLLHMWVDNPKIQLSFEIALKNLPPPFDSEPSLVRRVHSFLERHGFINFG 251
            :||||...:.|:|.:.|           .|||...|....| |.|..|:      :.::|
  Rat     9 KSGILIWGILLSISSCL-----------ASFEDIFKCFQDP-DYEALLL------IAQNG----- 50

  Fly   252 IFKRLKPIPAKKLGKVIVIGAGISGLAVAHQLQQFGMDVIVLEARDRVGGRISTFR--KNSYIAD 314
                |...|:.|  :::|:|||::||..|..||..|.:|.:|||.:.:|||:.|.|  :..:..:
  Rat    51 ----LHTSPSSK--RIVVVGAGMAGLVAAKLLQDAGHEVTILEASNHIGGRVVTLRNKEEGWHFE 109

  Fly   315 VGAMVVTGVYGNPMTILSKQIGMDLVPIQQ----TCPLY------------GPD--GKPV-PKEK 360
            :|.|.:...:....|.:.| .|:.|....|    |..|.            .|:  |.|: |.||
  Rat   110 LGPMRIPESHRIIHTYIQK-FGLKLNNFTQHDNNTWYLLRGHRYRASEVKANPEILGYPLRPSEK 173

  Fly   361 DDVIEREFNRLLESASYLSHRLDFNYAGDCP--VSLGDALEWIISMQEMQVMHKRGQHMQEIIAT 423
            :...|..|.:.:....          |.:|.  :||.|:                       .:|
  Rat   174 NKTAEDLFYQAITKVK----------ASNCSQLLSLYDS-----------------------YST 205

  Fly   424 QTKIIEQRRRLKTLRDTIGKLKNEHLAMINQRKPKGTDGDLKYCYQEFNIRNTQIKMEETISTFH 488
            :..::::           |.|....:.||         ||:               |.|....:.
  Rat   206 KAYLLKE-----------GMLSRGAVEMI---------GDM---------------MNENAGFYR 235

  Fly   489 DLHAEEKQMLAKLHELEQNRPSDVYLSSRDRLILDWHFANLEFANATRLNNLSLKHWDQDDDFEF 553
            .|             ||..|.::::                                .::|.|
  Rat   236 SL-------------LESLRIANIF--------------------------------TKNDQF-- 253

  Fly   554 IGHHTTVRNGYSCVPVALTENL---DIRVNSAVKEIKYGTKGVEVVAENLKTSNSQMTYKADLVV 615
                |.:..|:..:|.:|.::|   .|.:.|.|:.:......|||:......:::.....||.|:
  Rat   254 ----TEITGGFDQLPNSLNDSLKPGTIHLGSKVERVVGNESKVEVLYRTDGPTSALYNLTADYVI 314

  Fly   616 CTLTLGVLKVAVAHKESQQSNTVKFDPPLPDWKQQAIKRLGFGNLNKVVLCFDRIFWDPNANLFG 680
            .:.:            ::.:..:.|.|||...|.:|::.:.:.:..||:...:..||:.:..
  Rat   315 ISAS------------AKATRLIAFQPPLSPEKIRALRSVHYNSATKVIFVCNERFWEKDGI--- 364

  Fly   681 HVGSTTASRGEMFLFWSISSSP----VLLA----------LVAGMAANLVESVTDDIIIGRCMSV 731
            |.|.:...|...|:::...|.|    :|||          ..|.....:|:.:.||:.....:
  Rat   365 HGGYSITDRPSRFIYYPSYSRPSSKGILLASFTMDDDSFFFTALKPNQVVDIILDDLAAVHLI-- 427

  Fly   732 LKNIFGNTSVPQPKETV--------VTRWRSDPWARGSYSYVSVGSSGSDYDLLAAPVIPPSSKD 788
                        |||.:        |..|..||:..|||:..:......|...|:         .
  Rat   428 ------------PKEELKRMCPKSEVKHWSLDPFTIGSYAEFTPYQFLDDLKQLS---------Q 471

  Fly   789 AEGLPRLFFAGEHTIRNYP-ATVHGAYLSGLREAGRIAD 826
            .||  |::||||||  :.| |.:..|..||:|.|..|.|
  Rat   472 TEG--RIYFAGEHT--SLPHAWIETAIKSGIRAAKNIQD 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(var)3-3	NP_649194.1	SWIRM	165..250	CDD:282311	16/62 (26%)
		NAD_binding_8	269..327	CDD:290186	21/59 (36%)
		Amino_oxidase	274..824	CDD:279874	117/598 (20%)
Lao1	NP_001100152.1	NAD_binding_8	62..>125	CDD:290186	21/62 (34%)
Lao1	NP_001100152.1	Amino_oxidase	67..504	CDD:279874	117/598 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1231
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810