DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Su(var)3-3 and IL4I1

DIOPT Version :9

Sequence 1:	NP_649194.1	Gene:	Su(var)3-3 / 40217	FlyBaseID:	FBgn0260397	Length:	890	Species:	Drosophila melanogaster
Sequence 2:	NP_001244946.1	Gene:	IL4I1 / 259307	HGNCID:	19094	Length:	589	Species:	Homo sapiens

Alignment Length:	671	Identity:	158/671 - (23%)
Similarity:	250/671 - (37%)	Gaps:	189/671 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   248 INFGIFKRLKPIPAKKLGKVIVIGAGISGLAVAHQLQQFGMDVIVLEARDRVGGRISTFR--KNS 310
            :.:|:.:.|||      .:|||:|||::||..|..|...|..|.:|||.:|:||||.|:|  ...
Human    71 VTWGLNRTLKP------QRVIVVGAGVAGLVAAKVLSDAGHKVTILEADNRIGGRIFTYRDQNTG 129

  Fly   311 YIADVGAMVVTGVYGNPMTILSK---QIGMDLVPIQQTCPLYGPDGKPVPKEKDDVIEREFNRLL 372
            :|.::|||.:...:    .||.|   .:|::|....|.       .|....|..:|..|  |.::
Human   130 WIGELGAMRMPSSH----RILHKLCQGLGLNLTKFTQY-------DKNTWTEVHEVKLR--NYVV 181

  Fly   373 ESASYLSHRLDFNYAGDCPVSLGDALEWIISMQEMQVMHKRGQHMQEIIATQTKIIEQRRRLKTL 437
            |..               |..||.||.          ..::|...::|.  |..:.:..:.||.|
Human   182 EKV---------------PEKLGYALR----------PQEKGHSPEDIY--QMALNQALKDLKAL 219

  Fly   438 --RDTIGKLKNEHLAMINQRKPKGTDGDLKYCYQEFNIRNTQIKMEETISTFHDLHAEEKQMLAK 500
              |..:.|.:...|              |:|...|.|:....:::      ..|:.:|:
Human   220 GCRKAMKKFERHTL--------------LEYLLGEGNLSRPAVQL------LGDVMSED------ 258

  Fly   501 LHELEQNRPSDVYLSSRDRLILDWHFANLEFANATRLNNLSLKHWDQDDDFEFIGHHTTVRNGYS 565
                                    .|..|.||.|.|      .|....|..::    :.:..|:.
Human   259 ------------------------GFFYLSFAEALR------AHSCLSDRLQY----SRIVGGWD 289

  Fly   566 CVPVALTENLD--IRVNSAVKEIKYGTKGVEVVAENLKTSNSQMTYKADLVVCTLTLGVLKVAVA 628
            .:|.||..:|.  :.:|:.|..:..|...|.|..|....:.:....|||:|:.|.:...:|
Human   290 LLPRALLSSLSGLVLLNAPVVAMTQGPHDVHVQIETSPPARNLKVLKADVVLLTASGPAVK---- 350

  Fly   629 HKESQQSNTVKFDPPLPDWKQQAIKRLGFGNLNKVVLCFDRIFWDPNANLFGHVGSTTASR---- 689
                    .:.|.||||...|:|::||.:....||.|.|.|.||.......||..:...||
Human   351 --------RITFSPPLPRHMQEALRRLHYVPATKVFLSFRRPFWREEHIEGGHSNTDRPSRMIFY 407

  Fly   690 -----GEMFL---FWSISSSPVLLALVAGMAANLVESVTDDIIIGRCMSVLKNIFGNTSVPQPKE 746
                 |.:.|   .||.::     |..||::......:..|.:......|::.::..|.
Human   408 PPPREGALLLASYTWSDAA-----AAFAGLSREEALRLALDDVAALHGPVVRQLWDGTG------ 461

  Fly   747 TVVTRWRSDPWARGSYSYVSVGSSGSDYDLLAAPVIPPSSKDAEGLP--RLFFAGEHTIRNYPAT 809
             ||.||..|..::|.:             ::..|.:..:.||...:|  |::||||||.  ||
Human   462 -VVKRWAEDQHSQGGF-------------VVQPPALWQTEKDDWTVPYGRIYFAGEHTA--YP-- 508

  Fly   810 VHG----AYLSGLREAGRIADYYLGYPEGTPPDIGYSVAEAANLVSVGNVVKLRDLSPNLSDSSP 870
             ||    |..|.||.|.:|     ...:|...|.......|:::...|:|..:.        |||
Human   509 -HGWVETAVKSALRAAIKI-----NSRKGPASDTASPEGHASDMEGQGHVHGVA--------SSP 559

  Fly   871 S-SKKSEENSNSNTADSTELQ 890
            | ....||.|:........||
Human   560 SHDLAKEEGSHPPVQGQLSLQ 580

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(var)3-3	NP_649194.1	SWIRM	165..250	CDD:282311	0/1 (0%)
		NAD_binding_8	269..327	CDD:290186	24/59 (41%)
		Amino_oxidase	274..824	CDD:279874	133/576 (23%)
IL4I1	NP_001244946.1	NAD_binding_8	86..143	CDD:290186	24/56 (43%)
IL4I1	NP_001244946.1	Amino_oxidase	91..523	CDD:279874	132/573 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1231
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810