Protein Alignment Su(var)3-3 and IL4I1

DIOPT Version :10

• Sequence 1: NP_649194.1
• Gene: Su(var)3-3 / 40217
• FlyBaseID: FBgn0260397
• Length: 890
• Species: Drosophila melanogaster
• Sequence 2: NP_758962.1
• Gene: IL4I1 / 259307
• HGNCID: 19094
• Length: 589
• Species: Homo sapiens
• Alignment Length: 671
• Identity: 158/671 - (23%)
• Similarity: 250/671 - (37%)
• Gaps: 189/671 - (28%)

  Fly   248 INFGIFKRLKPIPAKKLGKVIVIGAGISGLAVAHQLQQFGMDVIVLEARDRVGGRISTFR--KNS 310
            :.:|:.:.|||      .:|||:|||::||..|..|...|..|.:|||.:|:||||.|:|  ...
Human    71 VTWGLNRTLKP------QRVIVVGAGVAGLVAAKVLSDAGHKVTILEADNRIGGRIFTYRDQNTG 129

  Fly   311 YIADVGAMVVTGVYGNPMTILSK---QIGMDLVPIQQTCPLYGPDGKPVPKEKDDVIEREFNRLL 372
            :|.::|||.:...:    .||.|   .:|::|....|.       .|....|..:|..|  |.::
Human   130 WIGELGAMRMPSSH----RILHKLCQGLGLNLTKFTQY-------DKNTWTEVHEVKLR--NYVV 181

  Fly   373 ESASYLSHRLDFNYAGDCPVSLGDALEWIISMQEMQVMHKRGQHMQEIIATQTKIIEQRRRLKTL 437
            |..               |..||.||.          ..::|...::|.  |..:.:..:.||.|
Human   182 EKV---------------PEKLGYALR----------PQEKGHSPEDIY--QMALNQALKDLKAL 219

  Fly   438 --RDTIGKLKNEHLAMINQRKPKGTDGDLKYCYQEFNIRNTQIKMEETISTFHDLHAEEKQMLAK 500
              |..:.|.:...|              |:|...|.|:....:::      ..|:.:|:
Human   220 GCRKAMKKFERHTL--------------LEYLLGEGNLSRPAVQL------LGDVMSED------ 258

  Fly   501 LHELEQNRPSDVYLSSRDRLILDWHFANLEFANATRLNNLSLKHWDQDDDFEFIGHHTTVRNGYS 565
                                    .|..|.||.|.|      .|....|..::    :.:..|:.
Human   259 ------------------------GFFYLSFAEALR------AHSCLSDRLQY----SRIVGGWD 289

  Fly   566 CVPVALTENLD--IRVNSAVKEIKYGTKGVEVVAENLKTSNSQMTYKADLVVCTLTLGVLKVAVA 628
            .:|.||..:|.  :.:|:.|..:..|...|.|..|....:.:....|||:|:.|.:...:|
Human   290 LLPRALLSSLSGLVLLNAPVVAMTQGPHDVHVQIETSPPARNLKVLKADVVLLTASGPAVK---- 350

  Fly   629 HKESQQSNTVKFDPPLPDWKQQAIKRLGFGNLNKVVLCFDRIFWDPNANLFGHVGSTTASR---- 689
                    .:.|.||||...|:|::||.:....||.|.|.|.||.......||..:...||
Human   351 --------RITFSPPLPRHMQEALRRLHYVPATKVFLSFRRPFWREEHIEGGHSNTDRPSRMIFY 407

  Fly   690 -----GEMFL---FWSISSSPVLLALVAGMAANLVESVTDDIIIGRCMSVLKNIFGNTSVPQPKE 746
                 |.:.|   .||.::     |..||::......:..|.:......|::.::..|.
Human   408 PPPREGALLLASYTWSDAA-----AAFAGLSREEALRLALDDVAALHGPVVRQLWDGTG------ 461

  Fly   747 TVVTRWRSDPWARGSYSYVSVGSSGSDYDLLAAPVIPPSSKDAEGLP--RLFFAGEHTIRNYPAT 809
             ||.||..|..::|.:             ::..|.:..:.||...:|  |::||||||.  ||
Human   462 -VVKRWAEDQHSQGGF-------------VVQPPALWQTEKDDWTVPYGRIYFAGEHTA--YP-- 508

  Fly   810 VHG----AYLSGLREAGRIADYYLGYPEGTPPDIGYSVAEAANLVSVGNVVKLRDLSPNLSDSSP 870
             ||    |..|.||.|.:|     ...:|...|.......|:::...|:|..:.        |||
Human   509 -HGWVETAVKSALRAAIKI-----NSRKGPASDTASPEGHASDMEGQGHVHGVA--------SSP 559

  Fly   871 S-SKKSEENSNSNTADSTELQ 890
            | ....||.|:........||
Human   560 SHDLAKEEGSHPPVQGQLSLQ 580

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Su(var)3-3	NP_649194.1	PLN03000	74..>827	CDD:178578	144/605 (24%)
IL4I1	NP_758962.1	YobN	75..529	CDD:440844	143/606 (24%)